Publicaciones 2012-2024

 

2024

 

Durante-Salmerón, D.A.; Fraile-Gutiérrez, I.; Gil-Gonzalo, R.; Acosta, N.; Aranaz, I.; Alcántara, A.R. Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review. Catalysts 2024, 14, 371, https://doi.org/ 10.3390/catal14060371

de Andrades, D.; Abellanas, P.; Carballares, D.; Alcantara, A.R.; Polizeli, M.d.L.T.d.M.; Rocha-Martin, J.; Fernandez-Lafuente, R. Adsorption features of reduced aminated supports modified with glutaraldehyde: Understanding the heterofunctional features of these supports. International Journal of Biological Macromolecules 2024, 263, 130403, https://doi.org/10.1016/j.ijbiomac.2024.130403

Alcántara, A.R.; Domínguez de María, P. Chapter 2 - Biocatalysis and Green Chemistry: assessing the greenness of enzymatic processes. In Biocatalysis in Asymmetric Synthesis, Gonzalo, G.D., Alcántara, A.R., Eds. Academic Press: 2024; https://doi.org/10.1016/B978-0-443-19057-5.00011-X

de Gonzalo, G.; Alcántara, A.R. Biocatalysis in Asymmetric Synthesis. de Gonzalo, G., Alcántara, A..R., Eds. Academic Press, Elsevier: London, UK, 2024; https://doi.org/10.1016/C2021-0-03391-5.

Alcántara, A.R.; de Gonzalo, G. Chapter 1 - Introduction to asymmetric synthesis employing biocatalysts. In Biocatalysis in Asymmetric Synthesis, Gonzalo, G.D., Alcántara, A.R., Eds. Academic Press: 2024; https://doi.org/10.1016/B978-0-443-19057-5.00010-8

Alcántara, A.R. Special Issue Entitled “10th Anniversary of Catalysts: Recent Advances in the Use of Catalysts for Pharmaceuticals”. Catalysts 2024, 14, https://doi.org/10.3390/catal14030161

Fraile-Gutiérrez, I.; Iglesias, S.; Acosta, N.; Revuelta, J. Chitosan-based oral hydrogel formulations of β-galactosidase to improve enzyme supplementation therapy for lactose intolerance. Int. J. Biol. Macromol. 2024, 255, https://doi.org/10.1016/j.ijbiomac.2023.127755

2023

 

Wollny, A.S.; Lavarda, G.; Papadopoulos, I.; López-Duarte, I.; Gotfredsen, H.; Hou, Y.; Tykwinski, R.R.; Torres, T.; Guldi, D.M. Förster Resonance Energy Transfer Sensitized Singlet Fission in BODIPY-Pentacene Dimer Conjugates. Adv. Opt. Mater. 2023, 11, https://doi.org/10.1002/adom.202300500

Sánchez, J.D.; Alcántara, A.R.; González, J.F.; Sánchez-Montero, J.M. Advances in the discovery of heterocyclic-based drugs against Alzheimer’s disease. Expert Opin. Drug. Discov. 2023, 18, 1413-1428, https://doi.org/10.1080/17460441.2023.2264766

Sánchez del Valle, F.J.; Fernández Dominguez, P.; Hernández Sanz, P. Construction and validation of a novel and severe hepatic injury model in swine focuses on research and training. Observational study. MethodsX 2023, 11, https://doi.org/10.1016/j.mex.2023.102362

Sánchez Del Valle, F.J.; De Nicolás, L.; Juan, G.M., Juan; Del Pozo, A.; Lidia, S.R.L. Utility of microporous polysaccharide hemospheres in severe hepatic trauma: Experimental study of hemostatic strength and ease of use. Injury 2023, 54, 339-344, https://doi.org/10.1016/j.injury.2022.11.045

Sánchez del Valle, F.J.; De Nicolás, L.; Fernández, G.; Fernández, P.; Gómez, E.; Aranaz, I. Comparison of a gelatin thrombin versus a modified absorbable polymer as a unique treatment for severe hepatic hemorrhage in swine. Sci. Rep. 2023, 13, https://doi.org/10.1038/s41598-023-41983-9

Robescu, M.S.; Alcántara, A.R.; Calvio, C.; Morelli, C.F.; Speranza, G.; Ubiali, D.; Bavaro, T. l-Theanine Goes Greener: A Highly Efficient Bioprocess Catalyzed by the Immobilized γ-Glutamyl Transferase from Bacillus subtilis. ChemSusChem 2023, 16, https://doi.org/10.1002/cssc.202202108

Rios, N.S.; Cipolatti, E.; Guimarães, J.R.; Tardioli, P.W.; Berenguer-Murcia, Á.; Rodrigues, R.C.; Alcántara, A.R.; Rocha-Martin, J.; Fernández-Lafuente, R. Use of magnetic nanoparticles to build magnetic macroporous biocatalyst: Prospects and trends. In Bionanocatalysis: From Design to Applications, Elsevier: 2023; https://doi.org/10.1016/B978-0-323-91760-5.00016-6. pp. 197-219.

Paez-Perez, M.; Vyšniauskas, A.; López-Duarte, I.; Lafarge, E.J.; López-Ríos De Castro, R.; Marques, C.M.; Schroder, A.P.; Muller, P.; Lorenz, C.D.; Brooks, N.J., et al. Directly imaging emergence of phase separation in peroxidized lipid membranes. Commun. Chem. 2023, 6, https://doi.org/10.1038/s42004-022-00809-x

Moyano, P.; Sola, E.; Naval, M.V.; Guerra-Menéndez, L.; Fernández, M.D.L.C.; del Pino, J. Neurodegenerative Proteinopathies Induced by Environmental Pollutants: Heat Shock Proteins and Proteasome as Promising Therapeutic Tools. Pharmaceutics 2023, 15, https://doi.org/10.3390/pharmaceutics15082048

Khiari, O.; Bouzemi, N.; Sánchez-Montero, J.M.; Alcántara, A.R. On the Use of Orthoformates as an Efficient Approach to Enhance the Enzymatic Enantioselective Synthesis of (S)-Ibuprofen. Catalysts 2023, 13, https://doi.org/10.3390/catal13020251

Khiari, O.; Bouzemi, N.; Sánchez-Montero, J.M.; Alcántara, A.R. Easy and Versatile Technique for the Preparation of Stable and Active Lipase-Based CLEA-like Copolymers by Using Two Homofunctional Cross-Linking Agents: Application to the Preparation of Enantiopure Ibuprofen. Int. J. Mol. Sci. 2023, 24, https://doi.org/10.3390/ijms241713664

Guimarães, J.R.; Carballares, D.; Rocha-Martin, J.; Alcántara, A.R.; Tardioli, P.W.; Fernandez-Lafuente, R. Heterofunctional Methacrylate Beads Bearing Octadecyl and Vinyl Sulfone Groups: Tricks to Obtain an Interfacially Activated Lipase from Thermomyces lanuginosus and Covalently Attached to the Support. Catalysts 2023, 13, https://doi.org/10.3390/catal13010108

García-Calvo, J.; Cranston, R.R.; López-Duarte, I.; Torres, T.; Lessard, B.H. Soluble Ruthenium Phthalocyanines as Semiconductors for Organic Thin-Film Transistors. ChemElectroChem 2023, 10, https://doi.org/10.1002/celc.202300286

da Rocha, T.N.; Morellon-Sterling, R.; Gonçalves, L.R.B.; Bolivar, J.M.; Alcántara, A.R.; Rocha-Martin, J.; Fernández-Lafuente, R. Synergy of Ion Exchange and Covalent Reaction: Immobilization of Penicillin G Acylase on Heterofunctional Amino-Vinyl Sulfone Agarose. Catalysts 2023, 13, https://doi.org/10.3390/catal13010151

Aranaz, I.; Navarro-García, F.; Morri, M.; Acosta, N.; Casettari, L.; Heras, A. Evaluation of chitosan salt properties in the production of AgNPs materials with antibacterial activity. Int. J. Biol. Macromol. 2023, 235, https://doi.org/10.1016/j.ijbiomac.2023.123849

Aranaz, I.; Acosta, N.; Revuelta, J.; Bastida, A.; Gómez-Casado, V.; Civera, C.; Garrido, L.; García-Junceda, E.; Heras, A.; Alcántara, A.R., et al. Fast and Sustained Axonal Growth by BDNF Released from Chitosan Microspheres. Mar. Drugs 2023, 21, https://doi.org/10.3390/md21020091

 

2022

 

Serra, I.; Wilson, L.; Alcántara, A.R. Editorial: Recent Advances in Biocatalysis: Focusing on Applications of These Processes. Front. Bioeng. Biotechnol. 2022, 10, https://doi.org/10.3389/fbioe.2022.844741

Rodriguez-Veiga, I.; Acosta, N.; Aranaz, I.; Dobrzycka-Krahel, A. Exploring Saduria entomon (Crustacea Isopoda) as a New Source for Chitin and Chitosan Isolation. Int. J. Mol. Sci. 2022, 23, https://doi.org/10.3390/ijms232416125

Nikoloudakis, E.; López-Duarte, I.; Charalambidis, G.; Ladomenou, K.; Ince, M.; Coutsolelos, A.G. Porphyrins and phthalocyanines as biomimetic tools for photocatalytic H2 production and CO2 reduction. Chem. Soc. Rev. 2022, 51, 6965-7045, https://doi.org/10.1039/d2cs00183g

Miele, M.; Pillari, V.; Pace, V.; Alcántara, A.R.; de Gonzalo, G. Application of Biobased Solvents in Asymmetric Catalysis. Molecules 2022, 27, https://doi.org/10.3390/molecules27196701

Miele, M.; Ielo, L.; Pillari, V.; Fernández, M.; Alcántara, A.R.; Pace, V. Biomass-derived Solvents. In Sustainable Organic Synthesis: Tools and Strategies, Protti, S., Palmieri, A., Eds. The Royal Society of Chemistry: Croydon, UK, 2022; https://doi.org/10.1039/9781839164842-00239 pp. 239-279.

Miele, M.; Ielo, L.; Pace, V.; Alcántara, A.R. Biocatalysis in green biosolvents. In Greener synthesis of organic compounds, First edition. ed.; Nag, A., Ed. CRC Press: Boca Raton, 2022; https://doi.org/10.1201/9781003089162.

Garcinuño, S.; Aranaz, I.; Civera, C.; Arias, C.; Acosta, N. Evaluating Non-Conventional Chitosan Sources for Controlled Release of Risperidone. Polym. 2022, 14, https://doi.org/10.3390/polym14071355

Fernández-Villa, D.; Ramírez-Jiménez, R.A.; Aranaz, I.; Acosta, N.; Vázquez-Lasa, B.; Rojo, L. Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments. Int. J. Mol. Sci. 2022, 23, https://doi.org/10.3390/ijms231710054

de Gonzalo, G.; Alcántara, A.R.; Domínguez de María, P.; Sánchez-Montero, J.M. Biocatalysis for the asymmetric synthesis of Active Pharmaceutical Ingredients (APIs): this time is for real. Expert Opin. Drug. Discov. 2022, 17, 1159-1171, https://doi.org/10.1080/17460441.2022.2114453

de Gonzalo, G.; Alcántara, A.R. Enzyme-catalyzed asymmetric synthesis. In Catalytic Asymmetric Synthesis, Wiley: 2022; https://doi.org/10.1002/9781119736424.ch14 pp. 531-558.

Chambers, J.E.; Zubkov, N.; Kubánková, M.; Nixon-Abell, J.; Mela, I.; Abreu, S.; Schwiening, M.; Lavarda, G.; López-Duarte, I.; Dickens, J.A., et al. Z-α1-antitrypsin polymers impose molecular filtration in the endoplasmic reticulum after undergoing phase transition to a solid state. Sci. Adv. 2022, 8, https://doi.org/10.1126/sciadv.abm2094

Aranaz, I.; Acosta, N. Chitin- and Chitosan-Based Composite Materials. Biomimetics 2022, 7, https://doi.org/10.3390/biomimetics7010001

Alcántara, A.R.; Domínguez de María, P.; Littlechild, J.A.; Schürmann, M.; Sheldon, R.A.; Wohlgemuth, R. Biocatalysis as Key to Sustainable Industrial Chemistry. ChemSusChem 2022, 15, e202102709, https://doi.org/10.1002/cssc.202102709

Alcántara, A.R.; Domínguez de María, P.; Littlechild, J.A.; Schürmann, M.; Sheldon, R.A.; Wohlgemuth, R. Preface to Special Issue on Biocatalysis as Key to Sustainable Industrial Chemistry. ChemSusChem 2022, 15, https://doi.org/10.1002/cssc.202200640

Affes, S.; Aranaz, I.; Acosta, N.; Heras, A.; Nasri, M.; Maalej, H. Physicochemical and biological properties of chitosan derivatives with varying molecular weight produced by chemical depolymerization. Biomass Convers. Biorefinery 2022, 10.1007/s13399-022-02662-3, https://doi.org/10.1007/s13399-022-02662-3

 

2021

 

Sherin, P.S.; Vyšniauskas, A.; López-Duarte, I.; Ogilby, P.R.; Kuimova, M.K. Visualising UV-A light-induced damage to plasma membranes of eye lens. J. Photochem. Photobiol. B Biol. 2021, 225, https://doi.org/10.1016/j.jphotobiol.2021.112346

Sánchez-Montero, J.M.; Agis-Torres, A.; Solano, D.; Söllhuber, M.; Fernández, M.; Villaro, W.; Gómez-Cañas, M.; García-Arencibia, M.; Fernández-Ruiz, J.; Egea, J., et al. Analogues of cannabinoids as multitarget drugs in the treatment of Alzheimer's disease. Eur. J. Pharmacol. 2021, 895, https://doi.org/10.1016/j.ejphar.2021.173875

Rabuffetti, M.; Cannazza, P.; Contente, M.L.; Pinto, A.; Romano, D.; Hoyos, P.; Alcántara, A.R.; Eberini, I.; Laurenzi, T.; Gourlay, L., et al. Structural insights into the desymmetrization of bulky 1,2-dicarbonyls through enzymatic monoreduction. Bioorg. Chem. 2021, 108, https://doi.org/10.1016/j.bioorg.2021.104644

Piedrabuena, D.; Rumbero, Á.; Pires, E.; Leal-Duaso, A.; Civera, C.; Fernández-Lobato, M.; Hernaiz, M.J. Enzymatic synthesis of novel fructosylated compounds by Ffase from Schwanniomyces occidentalis in green solvents. RSC Adv. 2021, 11, 24312-24319, https://doi.org/10.1039/d1ra01391b

Páez-Pérez, M.; López-Duarte, I.; Vyšniauskas, A.; Brooks, N.J.; Kuimova, M.K. Imaging non-classical mechanical responses of lipid membranes using molecular rotors. Chem. Sci. 2021, 12, 2604-2613, https://doi.org/10.1039/d0sc05874b

Monteiro, R.R.C.; Virgen-Ortiz, J.J.; Berenguer-Murcia, Á.; da Rocha, T.N.; dos Santos, J.C.S.; Alcántara, A.R.; Fernandez-Lafuente, R. Biotechnological relevance of the lipase A from Candida antarctica. Catal Today 2021, 362, 141-154, https://doi.org/10.1016/j.cattod.2020.03.026

McTiernan, C.D.; Zuñiga-Bustos, M.; Rosales-Rojas, R.; Barrias, P.; Griffith, M.; Poblete, H.; Sherin, P.S.; López-Duarte, I.; Kuimova, M.K.; Alarcon, E.I. Molecular rotors as reporters for viscosity of solutions of collagen like peptides. Phys. Chem. Chem. Phys. 2021, 23, 24545-24549, https://doi.org/10.1039/d1cp04398f

Ielo, L.; Miele, M.; Pillari, V.; Senatore, R.; Mirabile, S.; Gitto, R.; Holzer, W.; Alcántara, A.R.; Pace, V. Taking advantage of lithium monohalocarbenoid intrinsic α-elimination in 2-MeTHF: controlled epoxide ring-openingen routeto halohydrins. Org. Biomol. Chem. 2021, 19, 2038-2043, https://doi.org/10.1039/d0ob02407d

Del Arco, J.; Alcántara, A.R.; Fernández-Lafuente, R.; Fernández-Lucas, J. Magnetic micro-macro biocatalysts applied to industrial bioprocesses. Bioresour. Technol. 2021, 322, https://doi.org/10.1016/j.biortech.2020.124547

de Gonzalo, G.; Alcántara, A.R. Multienzymatic processes involving Baeyer–Villiger monooxygenases. Catalysts 2021, 11, https://doi.org/10.3390/catal11050605

de Gonzalo, G.; Alcántara, A.R. Recent developments in the synthesis of β-diketones. Pharmaceuticals 2021, 14, https://doi.org/10.3390/ph14101043

Aranaz, I.; Alcántara, A.R.; Civera, M.C.; Arias, C.; Elorza, B.; Heras, A.; Acosta, N. Chitosan: An overview of its properties and applications. Polym. 2021, 13, https://doi.org/10.3390/polym13193256

Arana-Peña, S.; Carballares, D.; Morellon-Sterlling, R.; Berenguer-Murcia, Á.; Alcántara, A.R.; Rodrigues, R.C.; Fernandez-Lafuente, R. Enzyme co-immobilization: Always the biocatalyst designers' choice…or not? Biotechnol. Adv. 2021, 51, https://doi.org/10.1016/j.biotechadv.2020.107584

Alcántara, A.R.; Plou, F.J. Special issue on “Applied biocatalysis in Europe: A sustainable tool for improving life quality”. Catalysts 2021, 11, 1-3, https://doi.org/10.3390/catal11030339

Affes, S.; Aranaz, I.; Acosta, N.; Heras, A.; Nasri, M.; Maalej, H. Chitosan derivatives-based films as pH-sensitive drug delivery systems with enhanced antioxidant and antibacterial properties. Int. J. Biol. Macromol. 2021, 182, 730-742, https://doi.org/10.1016/j.ijbiomac.2021.04.014

 

2020

 

Tejerina, L.; Yamamoto, S.; López-Duarte, I.; Martínez-Díaz, M.V.; Kimura, M.; Torres, T. Meso-Substituted Tetrabenzotriazaporphyrins for Dye-Sensitized Solar Cells. Helv. Chim. Acta 2020, 103, https://doi.org/10.1002/hlca.202000085

Shimolina, L.E.; Gulin, A.A.; Paez-Perez, M.; López-Duarte, I.; Druzhkova, I.N.; Lukina, M.M.; Gubina, M.V.; Brooks, N.J.; Zagaynova, E.V.; Kuimova, M.K., et al. Mapping cisplatin-induced viscosity alterations in cancer cells using molecular rotor and fluorescence lifetime imaging microscopy. J Biomed Opt 2020, 25, https://doi.org/10.1117/1.JBO.25.12.126004

Revuelta, J.; Aranaz, I.; Aranaz, I.; Acosta, N.; Acosta, N.; Civera, C.; Bastida, A.; Peña, N.; Monterrey, D.T.; Doncel-Pérez, E., et al. Unraveling the Structural Landscape of Chitosan-Based Heparan Sulfate Mimics Binding to Growth Factors: Deciphering Structural Determinants for Optimal Activity. ACS Appl. Mater. Interfaces 2020, 12, 25534-25545, https://doi.org/10.1021/acsami.0c03074

Ramos-Martín, J.; Khiari, O.; Alcántara, A.R.; Sánchez-Montero, J.M. Biocatalysis at extreme temperatures: Enantioselective synthesis of both enantiomers of mandelic acid by transesterification catalyzed by a thermophilic lipase in ionic liquids at 120◦c. Catalysts 2020, 10, 1-19, https://doi.org/10.3390/catal10091055

Monteiro, R.R.C.; Dos Santos, J.C.S.; Alcántara, A.R.; Fernandez-Lafuente, R. Enzyme-coated micro-crystals: An almost forgotten but very simple and elegant immobilization strategy. Catalysts 2020, 10, 1-27, https://doi.org/10.3390/catal10080891

Kornecki, J.F.; Carballares, D.; Tardioli, P.W.; Rodrigues, R.C.; Berenguer-Murcia, Á.; Alcántara, A.R.; Fernandez-Lafuente, R. Enzyme production of D-gluconic acid and glucose oxidase: Successful tales of cascade reactions. Catal. Sci. Technolog. 2020, 10, 5740-5771, https://doi.org/10.1039/d0cy00819b

Kashirina, A.S.; López-Duarte, I.; Kubánková, M.; Gulin, A.A.; Dudenkova, V.V.; Rodimova, S.A.; Torgomyan, H.G.; Zagaynova, E.V.; Meleshina, A.V.; Kuimova, M.K. Monitoring membrane viscosity in differentiating stem cells using BODIPY-based molecular rotors and FLIM. Sci. Rep. 2020, 10, https://doi.org/10.1038/s41598-020-70972-5

Flores, L.; López-Duarte, I.; Gómez-Lor, B.; Gutierrez-Puebla, E.; Hennrich, G. Supramolecular synthesis with: N -hetero-tolanes: Liquid crystals and hydrogen-bonded and halogen-bonded co-crystals. Crystengcomm 2020, 22, 416-419, https://doi.org/10.1039/c9ce01551e

Civera, C.; Del Valle, J.C.; Elorza, M.A.; Elorza, B.; Arias, C.; Díaz-Oliva, C.; Catalán, J.; García Blanco, F. Solvatochromism in urea/water and urea-derivative/water solutions. Phys. Chem. Chem. Phys. 2020, 22, 25165-25176, https://doi.org/10.1039/d0cp03816d

Arana-Peña, S.; Carballares, D.; Berenguer-Murcia, Á.; Alcántara, A.R.; Rodrigues, R.C.; Fernandez-Lafuente, R. One pot use of combilipases for full modification of oils and fats: Multifunctional and heterogeneous substrates. Catalysts 2020, 10, https://doi.org/10.3390/catal10060605

Affes, S.; Maalej, H.; Aranaz, I.; Kchaou, H.; Acosta, N.; Heras, A.; Nasri, M. Controlled size green synthesis of bioactive silver nanoparticles assisted by chitosan and its derivatives and their application in biofilm preparation. Carbohydr Polym 2020, 236, https://doi.org/10.1016/j.carbpol.2020.116063

Affes, S.; Maalej, H.; Aranaz, I.; Acosta, N.; Heras, A.; Nasri, M. Enzymatic production of low-Mw chitosan-derivatives: Characterization and biological activities evaluation. Int. J. Biol. Macromol. 2020, 144, 279-288, https://doi.org/10.1016/j.ijbiomac.2019.12.062

Alcántara, A.R. Biocatalyzed synthesis of antidiabetic drugs. In Pharmaceutical Biocatalysis : chemoenzymatic synthesis of active pharmaceutical ingredients, 1^st ed.; Grunwald, P., Ed. Jenny Stanford Publishing Pte. Ltd: Singapore, 2020; Vol. 5, pp. 349-418. https://doi.org/10.1201/9780429353116

 

2019

 

Woodcock, E.M.; Girvan, P.; Eckert, J.; Lopez-Duarte, I.; Kubánková, M.; van Loon, J.J.W.A.; Brooks, N.J.; Kuimova, M.K. Measuring Intracellular Viscosity in Conditions of Hypergravity. Biophys. J. 2019, 116, 1984-1993, https://doi.org/10.1016/j.bpj.2019.03.038

Tacias-Pascacio, V.G.; Ortiz, C.; Rueda, N.; Berenguer-Murcia, Á.; Acosta, N.; Aranaz, I.; Civera, C.; Fernandez-Lafuente, R.; Alcántara, A.R. Dextran aldehyde in biocatalysis: More than a mere immobilization system. Catalysts 2019, 9, https://doi.org/10.3390/catal9070622

Tacias-Pascacio, V.G.; García-Parra, E.; Vela-Gutiérrez, G.; Virgen-Ortiz, J.J.; Berenguer-Murcia, Á.; Alcántara, A.R.; Fernandez-Lafuente, R. Genipin as an emergent tool in the design of biocatalysts: Mechanism of reaction and applications. Catalysts 2019, 9, https://doi.org/10.3390/catal9121035

Rodrigues, R.C.; Virgen-Ortíz, J.J.; dos Santos, J.C.S.; Berenguer-Murcia, Á.; Alcántara, A.R.; Barbosa, O.; Ortiz, C.; Fernandez-Lafuente, R. Immobilization of lipases on hydrophobic supports: immobilization mechanism, advantages, problems, and solutions. Biotechnol. Adv. 2019, 37, 746-770, https://doi.org/10.1016/j.biotechadv.2019.04.003

Kubánková, M.; Summers, P.A.; López-Duarte, I.; Kiryushko, D.; Kuimova, M.K. Microscopic Viscosity of Neuronal Plasma Membranes Measured Using Fluorescent Molecular Rotors: Effects of Oxidative Stress and Neuroprotection. ACS Appl. Mater. Interfaces 2019, 11, 36307-36315, https://doi.org/10.1021/acsami.9b10426

Hoyos, P.; Pace, V.; Alcántara, A.R. Biocatalyzed synthesis of statins: A sustainable strategy for the preparation of valuable drugs. Catalysts 2019, 9, https://doi.org/10.3390/catal9030260

Hoyos, P.; Hernáiz, M.J.; Alcántara, A.R. Biocatalyzed production of fine chemicals. In Comprehensive Biotechnology, Elsevier: 2019; https://doi.org/10.1016/B978-0-12-809633-8.09153-6 pp. 334-373.

González, J.F.; Alcántara, A.R.; Doadrio, A.L.; Sánchez-Montero, J.M. Developments with multi-target drugs for Alzheimer’s disease: an overview of the current discovery approaches. Expert Opin. Drug. Discov. 2019, 14, 879-891, https://doi.org/10.1080/17460441.2019.1623201

Eerdekens, M.; López-Duarte, I.; Hennrich, G.; Verbiest, T. Thin films of tolane aggregates for faraday rotation: Materials and measurement. Coatings 2019, 9, https://doi.org/10.3390/coatings9100669

de María, P.D.; de Gonzalo, G.; Alcántara, A.R. Biocatalysis as useful tool in asymmetric synthesis: An assessment of recently granted patents (2014-2019). Catalysts 2019, 9, https://doi.org/10.3390/catal9100802

de Gonzalo, G.; Alcántara, A.R.; Domínguez de María, P. Cyclopentyl Methyl Ether (CPME): A Versatile Eco-Friendly Solvent for Applications in Biotechnology and Biorefineries. ChemSusChem 2019, 12, 2083-2097, https://doi.org/10.1002/cssc.201900079

Aranaz, I.; Alcántara, A.R.; Heras, A.; Acosta, N. Efficient reduction of Toluidine Blue O dye using silver nanoparticles synthesized by low molecular weight chitosans. Int. J. Biol. Macromol. 2019, 131, 682-690, https://doi.org/10.1016/j.ijbiomac.2019.03.119

Alcántara, A.R. Biocatalysis and pharmaceuticals: A smart tool for sustainable development. Catalysts 2019, 9, https://doi.org/10.3390/catal9100792

Affes, S.; Aranaz, I.; Hamdi, M.; Acosta, N.; Ghorbel-Bellaaj, O.; Heras, A.; Nasri, M.; Maalej, H. Preparation of a crude chitosanase from blue crab viscera as well as its application in the production of biologically active chito-oligosaccharides from shrimp shells chitosan. Int. J. Biol. Macromol. 2019, 139, 558-569, https://doi.org/10.1016/j.ijbiomac.2019.07.116

Hoyos, P.; Hernáiz, M.J.; Alcántara, A.R. Biocatalyzed production of fine chemicals. In Comprehensive Biotechnology, Elsevier: 2019; https://doi.org/10.1016/B978-0-12-809633-8.09153-6 pp. 334-373.

 

2018

 

Vyšniauskas, A.; Lopez-Duarte, I.; Thompson, A.J.; Bull, J.A.; Kuimova, M.K. Surface functionalisation with viscosity-sensitive BODIPY molecular rotor. Methods Appl. Fluoresc. 2018, 6, https://doi.org/10.1088/2050-6120/aabb2c

Santos-Moriano, P.; Kidibule, P.E.; Alleyne, E.; Ballesteros, A.O.; Heras, A.; Fernandez-Lobato, M.; Plou, F.J. Efficient conversion of chitosan into chitooligosaccharides by a chitosanolytic activity from Bacillus thuringiensis. Process Biochem. 2018, 73, 102-108, https://doi.org/10.1016/j.procbio.2018.07.017

Santos-Moriano, P.; Fernandez-Arrojo, L.; Mengibar, M.; Belmonte-Reche, E.; Peñalver, P.; Acosta, N.; Ballesteros, A.O.; Morales, J.C.; Kidibule, P.; Fernandez-Lobato, M., et al. Enzymatic production of fully deacetylated chitooligosaccharides and their neuroprotective and anti-inflammatory properties. Biocatal. Biotransform. 2018, 36, 57-67, https://doi.org/10.1080/10242422.2017.1295231

Sánchez, Á.; Mengíbar, M.; Fernández, M.; Alemany, S.; Heras, A.; Acosta, N. Influence of preparation methods of chitooligosaccharides on their physicochemical properties and their anti-inflammatory effects in mice and in RAW264.7 macrophages. Mar. Drugs 2018, 16, https://doi.org/10.3390/md16110430

Kubánková, M.; López-Duarte, I.; Kiryushko, D.; Kuimova, M.K. Molecular rotors report on changes in live cell plasma membrane microviscosity upon interaction with beta-amyloid aggregates. Soft Matter 2018, 14, 9466-9474, https://doi.org/10.1039/c8sm01633j

Garrido, L.; Aranaz, I.; Gallardo, A.; García, C.; García, N.; Benito, E.; Guzmán, J. Ionic conductivity, diffusion coefficients, and degree of dissociation in lithium electrolytes, ionic liquids, and hydrogel polyelectrolytes. J Phys Chem B 2018, 122, 8301-8308, https://doi.org/10.1021/acs.jpcb.8b06424

Garrido, L.; Aranaz, I.; Gallardo, A.; García, C.; García, N.; Benito, E.; Guzmán, J. Reply to "comment on 'Ionic Conductivity, Diffusion Coefficients and Degree of Dissociation in Lithium Electrolytes, Ionic Liquids and Hydrogel Polyelectrolytes'". J Phys Chem B 2018, 122, 10968-10969, https://doi.org/10.1021/acs.jpcb.8b10603

Doncel-Pérez, E.; Aranaz, I.; Bastida, A.; Revuelta, J.; Camacho, C.; Acosta, N.; Garrido, L.; Civera, C.; García-Junceda, E.; Heras, A., et al. Synthesis, physicochemical characterization and biological evaluation of chitosan sulfate as heparan sulfate mimics. Carbohydr Polym 2018, 191, 225-233, https://doi.org/10.1016/j.carbpol.2018.03.036

Chambers, J.E.; Kubánková, M.; Huber, R.G.; López-Duarte, I.; Avezov, E.; Bond, P.J.; Marciniak, S.J.; Kuimova, M.K. An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles. ACS Nano 2018, 12, 4398-4407, https://doi.org/10.1021/acsnano.8b00177

Castoldi, L.; Ielo, L.; Hoyos, P.; Hernáiz, M.J.; De Luca, L.; Alcántara, A.R.; Holzer, W.; Pace, V. Merging lithium carbenoid homologation and enzymatic reduction: A combinative approach to the HIV-protease inhibitor Nelfinavir. Tetrahedron 2018, 74, 2211-2217, https://doi.org/10.1016/j.tet.2018.03.034

Aranaz, I.; Castro, C.; Heras, A.; Acosta, N. On the ability of low molecular weight chitosan enzymatically depolymerized to produce and stabilize silver nanoparticles. Biomimetics 2018, 3, https://doi.org/10.3390/biomimetics3030021

Aranaz, I.; Acosta, N.; Heras, A. Enzymatic D-p-hydrophenyl glycine synthesis using chitin and chitosan as supports for biocatalyst immobilization. Biocatal. Biotransform. 2018, 36, 89-101, https://doi.org/10.1080/10242422.2017.1366991

Aranaz, I.; Acosta, N.; Civera, C.; Elorza, B.; Mingo, J.; Castro, C.; Gandía, M.L.; Heras, A. Cosmetics and cosmeceutical applications of chitin, chitosan and their derivatives. Polym. 2018, 10, https://doi.org/10.3390/polym10020213

Alkozi, H.A.; Sánchez-Montero, J.M.; Doadrio, A.L.; Pintor, J. Docking studies for melatonin receptors. Expert Opin. Drug. Discov. 2018, 13, 241-248, https://doi.org/10.1080/17460441.2018.1419184

Alcántara, C.M.; Alcántara, A.R. Biocatalyzed synthesis of antidiabetic drugs: A review. Biocatal. Biotransform. 2018, 36, 12-46, https://doi.org/10.1080/10242422.2017.1323887

Alcántara, A.R.; García-Junceda, E.; Gotor, V.; Plou, F.J. Biocatalysis in Spain: A field of success and innovation. Biocatal. Biotransform. 2018, 36, 180-183, https://doi.org/10.1080/10242422.2017.1420064

Hoyos, P.; Pace, V.; Alcántara, A.R. Chiral Building Blocks for Drugs Synthesis via Biotransformations. In Asymmetric Synthesis of Drugs and Natural Products, Nag, A., Ed. CRC Press: Boca Raton, Florida, 2018; pp. 346-448. https://doi.org/10.9774/gleaf.9781315302317

Alcántara, A.R.; Dominguez de Maria, P. Recent advances on the use of 2-methyltetrahydrofuran (2-MeTHF) in biotransformations. Curr. Green Chem. 2018, 5, 85-102, https://doi.org/10.2174/2213346105666180727100924

 

2017

 

Winkler, A.J.; Dominguez-Nuñez, J.A.; Aranaz, I.; Poza-Carrión, C.; Ramonell, K.; Somerville, S.; Berrocal-Lobo, M. Short-chain chitin oligomers: Promoters of plant growth. Mar. Drugs 2017, 15, https://doi.org/10.3390/md15020040

Vyšniauskas, A.; López-Duarte, I.; Duchemin, N.; Vu, T.T.; Wu, Y.; Budynina, E.M.; Volkova, Y.A.; Peña Cabrera, E.; Ramírez-Ornelas, D.E.; Kuimova, M.K. Exploring viscosity, polarity and temperature sensitivity of BODIPY-based molecular rotors. Phys. Chem. Chem. Phys. 2017, 19, 25252-25259, https://doi.org/10.1039/c7cp03571c

Shimolina, L.E.; Izquierdo, M.A.; López-Duarte, I.; Bull, J.A.; Shirmanova, M.V.; Klapshina, L.G.; Zagaynova, E.V.; Kuimova, M.K. Imaging tumor microscopic viscosity in vivo using molecular rotors. Sci. Rep. 2017, 7, https://doi.org/10.1038/srep41097

Sherin, P.S.; López-Duarte, I.; Dent, M.R.; Kubánková, M.; Vyšniauskas, A.; Bull, J.A.; Reshetnikova, E.S.; Klymchenko, A.S.; Tsentalovich, Y.P.; Kuimova, M.K. Visualising the membrane viscosity of porcine eye lens cells using molecular rotors. Chem. Sci. 2017, 8, 3523-3528, https://doi.org/10.1039/c6sc05369f

Sánchez, Á.; Mengíbar, M.; Rivera-Rodríguez, G.; Moerchbacher, B.; Acosta, N.; Heras, A. The effect of preparation processes on the physicochemical characteristics and antibacterial activity of chitooligosaccharides. Carbohydr Polym 2017, 157, 251-257, https://doi.org/10.1016/j.carbpol.2016.09.055

Peniche, C.J.; Peniche, H.; Bada, N.; Sáez, V.; Acosta, N.; Penichei, C.A. Design of a parenteral formulation for prolonged risperidone release based on an in situ gelification system. Rev. Cuba. Invest. Biomed. 2017, 36,

Mengíbar, M.; Miralles, B.; Heras, A. Use of soluble chitosans in Maillard reaction products with β-lactoglobulin. Emulsifying and antioxidant properties. LWT 2017, 75, 440-446, https://doi.org/10.1016/j.lwt.2016.09.016

Martínez-Campos, E.; Civantos, A.; Redondo, J.A.; Guzmán, R.; Pérez-Perrino, M.; Gallardo, A.; Ramos, V.; Aranaz, I. Cell Adhesion and Proliferation on Sulfonated and Non-Modified Chitosan Films. AAPS PharmSciTech 2017, 18, 974-982, https://doi.org/10.1208/s12249-016-0619-7

Kubánková, M.; López-Duarte, I.; Bull, J.A.; Vadukul, D.M.; Serpell, L.C.; de Saint Victor, M.; Stride, E.; Kuimova, M.K. Probing supramolecular protein assembly using covalently attached fluorescent molecular rotors. Biomaterials 2017, 139, 195-201, https://doi.org/10.1016/j.biomaterials.2017.06.009

Doadrio, A.L.; Sánchez-Montero, J.M.; Doadrio, J.C.; Salinas, A.J.; Vallet-Regí, M. Mesoporous silica nanoparticles as a new carrier methodology in the controlled release of the active components in a polypill. Eur. J. Pharm. Sci. 2017, 97, 1-8, https://doi.org/10.1016/j.ejps.2016.11.002

Castejón, D.; Herrera, A.; Heras, A.; Cambero, I.; Mateos-Aparicio, I. Oil Quality Control of Culinary Oils Subjected to Deep-Fat Frying Based on NMR and EPR Spectroscopy. Food Anal. Methods. 2017, 10, 2467-2480, https://doi.org/10.1007/s12161-016-0778-x

Callol-Sanchez, L.; Muñoz-Lucas, M.A.; Gomez-Martin, O.; Maldonado-Sanz, J.A.; Civera-Tejuca, C.; Gutierrez-Ortega, C.; Rodriguez-Trigo, G.; Jareno-Esteban, J. Observation of nonanoic acid and aldehydes in exhaled breath of patients with lung cancer. J. Breath Res. 2017, 11, https://doi.org/10.1088/1752-7163/aa6485

Aranaz, I.; Paños, I.; Peniche, C.; Heras, A.; Acosta, N. Chitosan spray-dried microparticles for controlled delivery of venlafaxine hydrochloride. Molecules 2017, 22, https://doi.org/10.3390/molecules22111980

Aranaz, I.; Martínez-Campos, E.; Moreno-Vicente, C.; Civantos, A.; García-Arguelles, S.; del Monte, F. Macroporous calcium phosphate/chitosan composites prepared via unidirectional ice segregation and subsequent freeze-drying. Mater. 2017, 10, https://doi.org/10.3390/ma10050516

Hoyos, P.; Hernáiz, M.J.; Alcántara, A.R. Biocatalyzed Production of Fine Chemicals. In Reference Module in Life Sciences, Moo-Young, M., Ed. Pergamon: Oxford, United Kingdom, 2017; http://dx.doi.org/10.1016/B978-0-12-809633-8.09153-6.

 

2016

 

Sánchez-Montero, J.M. Cannabinoid analogs in the treatment of pain. An. R. Acad. Farm. 2016, 82, 222-242,

Mateos-Aparicio, I.; Mengíbar, M.; Heras, A. Effect of chito-oligosaccharides over human faecal microbiota during fermentation in batch cultures. Carbohydr Polym 2016, 137, 617-624, https://doi.org/10.1016/j.carbpol.2015.11.011

Hoyos, P.; Pace, V.; Hernáiz, M.J.; Alcántara, A.R. Dynamic Kinetic Resolution via Hydrolase-Metal Combo Catalysis. In Green Biocatalysis, wiley: 2016; https://doi.org/10.1002/9781118828083.ch14 pp. 373-396.

Hortigüela, M.J.; Yuste, L.; Rojo, F.; Aranaz, I. Green synthesis of hierarchically structured silver-polymer nanocomposites with antibacterial activity. Nanomaterials 2016, 6, https://doi.org/10.3390/nano6080137

Hirata, D.B.; Albuquerque, T.L.; Rueda, N.; Sánchez-Montero, J.M.; Garcia-Verdugo, E.; Porcar, R.; Fernandez-Lafuente, R. Advantages of Heterofunctional Octyl Supports: Production of 1,2-Dibutyrin by Specific and Selective Hydrolysis of Tributyrin Catalyzed by Immobilized Lipases. ChemistrySelect 2016, 1, 3259-3270, https://doi.org/10.1002/slct.201600274

Fernández-de Castro, L.; Mengíbar, M.; Sánchez, Á.; Arroyo, L.; Villarán, M.C.; Díaz de Apodaca, E.; Heras, A. Films of chitosan and chitosan-oligosaccharide neutralized and thermally treated: Effects on its antibacterial and other activities. LWT 2016, 73, 368-374, https://doi.org/10.1016/j.lwt.2016.06.038

Dent, M.R.; López-Duarte, I.; Dickson, C.J.; Chairatana, P.; Anderson, H.L.; Gould, I.R.; Wylie, D.; Vyšniauskas, A.; Brooks, N.J.; Kuimova, M.K. Imaging plasma membrane phase behaviour in live cells using a thiophene-based molecular rotor. Chem. Commun. 2016, 52, 13269-13272, https://doi.org/10.1039/c6cc05954f

Cuenca, S.; Mansilla, C.; Aguado, M.; Yuste-Calvo, C.; Sánchez, F.; Sánchez-Montero, J.M.; Ponz, F. Nanonets derived from turnip mosaic virus as scaffolds for increased enzymatic activity of immobilized Candida antarctica lipase B. Front. Plant Sci. 2016, 7, https://doi.org/10.3389/fpls.2016.00464

Civantos, A.; Martinez-Campos, E.; Nash, M.E.; Gallardo, A.; Ramos, V.; Aranaz, I. Polymeric and Non-Polymeric Platforms for Cell Sheet Detachment. In Advanced Materials Interfaces, wiley: 2016; https://doi.org/10.1002/9781119242604.ch13 pp. 463-495.

Aranaz, I.; Harris, R.; Navarro-García, F.; Heras, A.; Acosta, N. Chitosan based films as supports for dual antimicrobial release. Carbohydr Polym 2016, 146, 402-410, https://doi.org/10.1016/j.carbpol.2016.03.064

Aranaz, I.; Acosta, N.; Mengíbar, M.N.; Calderón, L.; Harris, R.; Heras, A. InFiQuS: Making the Best of Leftovers. In Industrial Biorenewables: A Practical Viewpoint, wiley: 2016; https://doi.org/10.1002/9781118843796.ch15 pp. 341-370.

 

2015

 

Serra, I.; Daly, S.; Alcántara, A.R.; Bianchi, D.; Terreni, M.; Ubiali, D. Redesigning the synthesis of vidarabine via a multienzymatic reaction catalyzed by immobilized nucleoside phosphorylases. RSC Adv. 2015, 5, 23569-23577, https://doi.org/10.1039/c4ra15018j

Pizzilli, A.; Zoppi, R.; Hoyos, P.; Gómez, S.; Gatti, F.G.; Hernáiz, M.J.; Alcántara, A.R. First stereoselective acylation of a primary diol possessing a prochiral quaternary center mediated by lipase TL from Pseudomonas stutzeri. Tetrahedron 2015, 71, 9172-9176, https://doi.org/10.1016/j.tet.2015.09.056

López-Duarte, I.; Chairatana, P.; Wu, Y.; Pérez-Moreno, J.; Bennett, P.M.; Reeve, J.E.; Boczarow, I.; Kaluza, W.; Hosny, N.A.; Stranks, S.D., et al. Thiophene-based dyes for probing membranes. Org. Biomol. Chem. 2015, 13, 3792-3802, https://doi.org/10.1039/c4ob02507e

Jatunov, S.; Franconetti, A.; Prado-Gotor, R.; Heras, A.; Mengíbar, M.; Cabrera-Escribano, F. Fluorescent imino and secondary amino chitosans as potential sensing biomaterials. Carbohydr Polym 2015, 123, 288-296, https://doi.org/10.1016/j.carbpol.2015.01.061

Doadrio, A.L.; Salinas, A.J.; Sánchez-Montero, J.M.; Vallet-Regí, M. Drug release from ordered mesoporous silicas. Curr. Pharm. Des. 2015, 21, 6213-6819,

Dent, M.R.; López-Duarte, I.; Dickson, C.J.; Geoghegan, N.D.; Cooper, J.M.; Gould, I.R.; Krams, R.; Bull, J.A.; Brooks, N.J.; Kuimova, M.K. Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors. Phys. Chem. Chem. Phys. 2015, 17, 18393-18402, https://doi.org/10.1039/c5cp01937k

Aranaz, I.; Acosta, N.; Férnandez-Valle, M.E.; Heras, A. Optimization of d-amino acid production catalyzed by immobilized multi-enzyme system in polyelectrolyte complex gel capsules. J. Mol. Catal. B Enzym. 2015, 121, 45-52, https://doi.org/10.1016/j.molcatb.2015.06.003

Aires-Trapote, A.; Hoyos, P.; Alcántara, A.R.; Tamayo, A.; Rubio, J.; Rumbero, A.; Hernáiz, M.J. Covalent Immobilization of Pseudomonas stutzeri Lipase on a Porous Polymer: An Efficient Biocatalyst for a Scalable Production of Enantiopure Benzoin Esters under Sustainable Conditions. Org. Process Res. Dev. 2015, 19, 687-694, https://doi.org/10.1021/op500326k

Acosta, N.; Sánchez, E.; Calderón, L.; Córdoba-Diaz, M.; Córdoba-Diaz, D.; Dom, S.; Heras, A. Physical stability studies of semi-solid formulations from natural compounds loaded with Chitosan Microspheres. Mar. Drugs 2015, 13, 5901-5919, https://doi.org/10.3390/md13095901

 

2014

 

Pintado-Sierra, M.; Delgado, L.; Aranaz, I.; Marcos-Fernández, Á.; Reinecke, H.; Gallardo, A.; Zeugolis, D.; Elvira, C. Surface hierarchical porosity in poly (ε-caprolactone) membranes with potential applications in tissue engineering prepared by foaming in supercritical carbon dioxide. J. Supercritical Fluids 2014, 95, 273-284, https://doi.org/10.1016/j.supflu.2014.09.019

Moia, D.; Vaissier, V.; López-Duarte, I.; Torres, T.; Nazeeruddin, M.K.; O'Regan, B.C.; Nelson, J.; Barnes, P.R.F. The reorganization energy of intermolecular hole hopping between dyes anchored to surfaces. Chem. Sci. 2014, 5, 281-290, https://doi.org/10.1039/c3sc52359d

López-Duarte, I.; Truc Vu, T.; Izquierdo, M.A.; Bull, J.A.; Kuimova, M.K. A molecular rotor for measuring viscosity in plasma membranes of live cells. Chem. Commun. 2014, 50, 5282-5284, https://doi.org/10.1039/c3cc47530a

Doadrio, A.L.; Sánchez-Montero, J.M.; Doadrio, J.C.; Salinas, A.J.; Vallet-Regí, M. A molecular model to explain the controlled release from SBA-15 functionalized with APTES. Microporous Mesoporous Mater. 2014, 195, 43-49, https://doi.org/10.1016/j.micromeso.2014.04.019

Civera, C.; Arias, C.; Elorza, M.A.; Elorza, B.; García-Blanco, F.; Galera-Gómez, P.A. Hydrophobicity enhancement in micelles of Triton X-165 by the presence of the cosolvent 2,2,2 trifluoroethanol (TFE). J Mol Liq 2014, 199, 29-34, https://doi.org/10.1016/j.molliq.2014.08.017

Bocourt, M.; Bada, N.; Acosta, N.; Bucio, E.; Peniche, C. Synthesis and characterization of novel pH-sensitive chitosan-poly(acrylamide-co-itaconic acid) hydrogels. Polym. Int. 2014, 63, 1715-1723, https://doi.org/10.1002/pi.4699

Aranaz, I.; Mengíbar, M.; Harris, R.; Miralles, B.; Acosta, N.; Calderón, L.; Sánchez, Á.; Heras, A. Role of physicochemical properties of chitin and chitosan on their functionality. Curr. Chem. Biol. 2014, 8, 27-42, https://doi.org/10.2174/221279680801141112095704

Aranaz, I.; Martínez-Campos, E.; Nash, M.E.; Tardajos, M.G.; Reinecke, H.; Elvira, C.; Ramos, V.; López-Lacomba, J.L.; Gallardo, A. Pseudo-double network hydrogels with unique properties as supports for cell manipulation. J. Mater. Chem. B 2014, 2, 3839-3848, https://doi.org/10.1039/c4tb00371c

Aranaz, I.; Gutiérrez, M.C.; Ferrer, M.L.; Del Monte, F. Preparation of chitosan nanocomposites with a macroporous structure by unidirectional freezing and subsequent freeze-drying. Mar. Drugs 2014, 12, 5619-5642, https://doi.org/10.3390/md12115619

Alonso-Fagúndez, N.; Laserna, V.; Alba-Rubio, A.C.; Mengibar, M.; Heras, A.; Mariscal, R.; Granados, M.L. Poly-(styrene sulphonic acid): An acid catalyst from polystyrene waste for reactions of interest in biomass valorization. Catal Today 2014, 234, 285-294, https://doi.org/10.1016/j.cattod.2014.01.041

Alcántara, A.R.; Pace, V.; Hoyos, P.; Sandoval, M.; Holzer, W.; Hernáiz, M.J. Chemoenzymatic synthesis of carbohydrates as antidiabetic and anticancer drugs. Curr. Top. Med. Chem. 2014, 14, 2694-2711, https://doi.org/10.2174/1568026614666141215151056

Agis-Torres, A.; Söllhuber, M.; Fernández, M.; Sánchez-Montero, J.M. Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease. Curr. Neuropharmacol. 2014, 12, 2-36, https://doi.org/10.2174/1570159X113116660047

 

2013

 

Tardajos, M.G.; Aranaz, I.; Pérez, M.; López, D.; Reinecke, H.; Elvira, C.; Gallardo, A. Self-structuring in amphiphilic networks prepared by single conventional radical copolymerization of n -butyl methacrylate and vinylpyrrolidone. Macromolecules 2013, 46, 5018-5025, https://doi.org/10.1021/ma400483f

Sandoval, M.; Civera, C.; Berenguer, J.; García-Blanco, F.; Hernaiz, M.J. Optimised N-acetyl-D-lactosamine synthesis using Thermus thermophilus β-galactosidase in bio-solvents. Tetrahedron 2013, 69, 1148-1152, https://doi.org/10.1016/j.tet.2012.11.053

Quiñones, J.P.; Gothelf, K.V.; Kjems, J.; Yang, C.; Heras, A.; Schmidt, C.; Covas, C.P. Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol. Carbohydr Polym 2013, 92, 856-864, https://doi.org/10.1016/j.carbpol.2012.10.005

Quiñones, J.P.; Gothelf, K.V.; Kjems, J.; Heras, A.; Schmidt, C.; Peniche, C. Novel self-assembled nanoparticles of testosterone- modified glycol chitosan and fructose chitosan for controlled release. J. Biomater. Tissue Eng. 2013, 3, 164-172, https://doi.org/10.1166/jbt.2013.1071

Quiñones, J.P.; Gothelf, K.V.; Kjems, J.; Heras, A.; Schmidt, C.; Covas, C.P. N,O6-partially acetylated chitosan nanoparticles hydrophobically-modified for controlled release of steroids and vitamin e. Carbohydr Polym 2013, 91, 143-151, https://doi.org/10.1016/j.carbpol.2012.07.080

Pérez, M.; Redondo, J.A.; Gallardo, A.; Aranaz, I. Preparation of chitin and chitosan derivatives having mercapto groups. In Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments, CRC Press: 2013; https://doi.org/10.1201/b15636 pp. 113-120.

Pace, V.; Hoyos, P.; Alcántara, A.R.; Holzer, W. Chemoselective CaO-mediated acylation of alcohols and amines in 2-methyltetrahydrofuran. ChemSusChem 2013, 6, 905-910, https://doi.org/10.1002/cssc.201200922

Pace, V.; Holzer, W.; Verniest, G.; Alcántara, A.R.; De Kimpe, N. Chemoselective synthesis of N-substituted α-amino-α′- chloro ketones via chloromethylation of glycine-derived Weinreb amides. Adv. Synth. Catal. 2013, 355, 919-926, https://doi.org/10.1002/adsc.201201043

Pace, V.; Castoldi, L.; Hernáiz, M.J.; Alcántara, A.R.; Holzer, W. Chemoselective oxidative hydrolysis of EWG protected α-arylamino vinyl bromides to α-arylamino-α′-bromoacetones. Tetrahedron Lett. 2013, 54, 4369-4372, https://doi.org/10.1016/j.tetlet.2013.05.118

Pace, V.; Castoldi, L.; Alcántara, A.R.; Holzer, W. Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water. RSC Adv. 2013, 3, 10158-10162, https://doi.org/10.1039/c3ra41262h

Montejo, C.; Civera, C.; Barcia, E.; Negro, S.; Fernández-Carballido, A. Development and validation of a reversed-phase liquid chromatography method for the quantification of meloxicam in liposomes. Acta Chromatogr. 2013, 25, 639-653, https://doi.org/10.1556/AChrom.25.2013.4.4

Mengíbar, M.; Mateos-Aparicio, I.; Miralles, B.; Heras, A. Influence of the physico-chemical characteristics of chito-oligosaccharides (COS) on antioxidant activity. Carbohydr Polym 2013, 97, 776-782, https://doi.org/10.1016/j.carbpol.2013.05.035

Maraite, A.; Hoyos, P.; Carballeira, J.D.; Cabrera, Á.C.; Ansorge-Schumacher, M.B.; Alcántara, A.R. Lipase from Pseudomonas stutzeri: Purification, homology modelling and rational explanation of the substrate binding mode. J. Mol. Catal. B Enzym. 2013, 87, 88-98, https://doi.org/10.1016/j.molcatb.2012.11.005

López-Duarte, I.; Reeve, J.E.; Pérez-Moreno, J.; Boczarow, I.; Depotter, G.; Fleischhauer, J.; Clays, K.; Anderson, H.L. “Push-no-pull” porphyrins for second harmonic generation imaging. Chem. Sci. 2013, 4, 2024-2027, https://doi.org/10.1039/c3sc22306j

Jareño-Esteban, J.J.; Muñoz-Lucas, M.T.; Carrillo-Aranda, B.; Maldonado-Sanz, J.T.; de Granda-Orive, I.; Aguilar-Ros, A.; Civera, C.; Gutiérrez-Ortega, C.; Callol-Sánchez, L.M. Volatile Organic Compounds in Exhaled Breath in a Healthy Population: Effect of Tobacco Smoking. Arch. Bronconeumol. 2013, 49, 457-461, https://doi.org/10.1016/j.arbr.2013.09.006

Hoyos, P.; Pace, V.; Alcántara, A.R. Biocatalyzed on water synthesis of chiral building blocks for the preparation of anti-cancer drugs: A greener approach. Curr. Org. Chem. 2013, 17, 1132-1157, https://doi.org/10.2174/1385272811317110003

Harris, R.; Acosta, N.; Heras, A. Chitosan and inhalers: A bioadhesive polymer for pulmonary drug delivery. In Inhaler Devices: Fundamentals, Design and Drug Delivery, Elsevier Ltd.: 2013; https://doi.org/10.1533/9780857098696.2.77 pp. 77-93.

Fernández-Lucas, J.; Harris, R.; Mata-Casar, I.; Heras, A.; De La Mata, I.; Arroyo, M. Magnetic chitosan beads for covalent immobilization of nucleoside 2′-deoxyribosyltransferase: Application in nucleoside analogues synthesis. J. Ind. Microbiol. Biotechnol. 2013, 40, 955-966, https://doi.org/10.1007/s10295-013-1304-4

Calderón, L.; Harris, R.; Córdoba-Diaz, M.; Elorza, M.; Elorza, B.; Lenoir, J.; Adriaens, E.; Remon, J.P.; Heras, A.; Cordoba-Diaz, D. Nano and microparticulate chitosan-based systems for antiviral topical delivery. Eur. J. Pharm. Sci. 2013, 48, 216-222, https://doi.org/10.1016/j.ejps.2012.11.002

Bayón, C.; Cortés, Á.; Aires-Trapote, A.; Civera, C.; Hernáiz, M.J. Highly efficient and regioselective enzymatic synthesis of β-(1→3) galactosides in biosolvents. RSC Adv. 2013, 3, 12155-12163, https://doi.org/10.1039/c3ra40860d

 

2012

 

Tardajos, M.G.; Aranaz, I.; Sayar, F.; Elvira, C.; Reinecke, H.; Piskin, E.; Gallardo, A. Chemical guiding of magnetic nanoparticles in dispersed media containing poly-(methylmethacrylate-co-vinylpyrrolidone). Langmuir 2012, 28, 5555-5561, https://doi.org/10.1021/la204900c

Sandoval, M.; Cortés, Á.; Civera, C.; Treviño, J.; Ferreras, E.; Vaultier, M.; Berenguer, J.; Lozano, P.; Hernáiz, M.J. Efficient and selective enzymatic synthesis of N-acetyl-lactosamine in ionic liquid: A rational explanation. RSC Adv. 2012, 2, 6306-6314, https://doi.org/10.1039/c2ra20618h

Quiñones, J.P.; Gothelf, K.V.; Kjems, J.; Heras, A.; Schmidt, C.; Covas, C.P. Self-assembled nanoparticles of glycol chitosan - Ergocalciferol succinate conjugate, for controlled release. Carbohydr Polym 2012, 88, 1373-1377, https://doi.org/10.1016/j.carbpol.2012.02.039

Pace, V.; Hoyos, P.; Castoldi, L.; Domínguez de María, P.; Alcántara, A.R. 2-Methyltetrahydrofuran (2-MeTHF): A biomass-derived solvent with broad application in organic chemistry. ChemSusChem 2012, 5, 1369-1379, https://doi.org/10.1002/cssc.201100780

Pace, V.; Castoldi, L.; Alcántara, A.R.; Holzer, W. Robust eco-friendly protocol for the preparation of γ-hydroxy- α,β-acetylenic esters by sequential one-pot elimination-addition of 2-bromoacrylates to aldehydes promoted by LTMP in 2-MeTHF. Green Chem. 2012, 14, 1859-1863, https://doi.org/10.1039/c2gc35305a

Okoli, C.; Sanchez-Dominguez, M.; Boutonnet, M.; Järås, S.; Civera, C.; Solans, C.; Kuttuva, G.R. Comparison and functionalization study of microemulsion-prepared magnetic iron oxide nanoparticles. Langmuir 2012, 28, 8479-8485, https://doi.org/10.1021/la300599q

Muñoz Solano, D.; Hoyos, P.; Hernáiz, M.J.; Alcántara, A.R.; Sánchez-Montero, J.M. Industrial biotransformations in the synthesis of building blocks leading to enantiopure drugs. Bioresour. Technol. 2012, 115, 196-207, https://doi.org/10.1016/j.biortech.2011.11.131

López-Duarte, I.; Wang, M.; Humphry-Baker, R.; Ince, M.; Martínez-Díaz, M.V.; Nazeeruddin, M.K.; Torres, T.; Grätzel, M. Molecular engineering of zinc phthalocyanines with phosphinic acid anchoring groups. Angew. Chem. Int. Ed. 2012, 51, 1895-1898, https://doi.org/10.1002/anie.201105950

López-Duarte, I.; Martínez-Díaz, M.V.; Schwartz, E.; Koepf, M.; Kouwer, P.H.J.; Rowan, A.E.; Nolte, R.J.M.; Torres, T. Postfunctionalization of helical polyisocyanopeptides with phthalocyanine chromophores by "click chemistry". ChemPlusChem 2012, 77, 700-706, https://doi.org/10.1002/cplu.201200087

Hoyos, P.; Pace, V.; Alcántara, A.R. Dynamic kinetic resolution via hydrolase-metal combo catalysis in stereoselective synthesis of bioactive compounds. Adv. Synth. Catal. 2012, 354, 2585-2611, https://doi.org/10.1002/adsc.201200365

Fragnelli, M.C.; Hoyos, P.; Romano, D.; Gandolfi, R.; Alcántara, A.R.; Molinari, F. Enantioselective reduction and deracemisation using the non-conventional yeast Pichia glucozyma in water/organic solvent biphasic systems: Preparation of (S)-1,2-diaryl-2-hydroxyethanones (benzoins). Tetrahedron 2012, 68, 523-528, https://doi.org/10.1016/j.tet.2011.11.014

De Mey, K.; Perez-Moreno, J.; Reeve, J.E.; Lopez-Duarte, I.; Boczarow, I.; Anderson, H.L.; Clays, K. Strong wavelength dependence of hyperpolarizability in the near-infrared biological window for second-harmonic generation by amphiphilic porphyrins. J. Phys. Chem. C 2012, 116, 13781-13787, https://doi.org/10.1021/jp302050j