Grupos de investigación

  1. Portada
  2. Publications

Publications

 

Publications

Authors affiliated to the Department of Biochemistry and Molecular Biology are underlined. (*) PI is the corresponding author. (‡) Similar contribution.

  1. Feo-Lucas L, Godio C, Minguito de la Escalera M, Álvarez-Ladrón N, Villarrubia LH, Vega-Pérez A, González-Cintado L, Domínguez-Andrés J, García-Fojeda B, Montero-Fernández C, Casals C, Autilio C, Pérez-Gil J, Crainiciuc G, Hidalgo A, López-Bravo M and Ardavín C (2023) Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction. Front. Immunol, 14:1125984.  Sec. Mucosal Immunity.PDF  doi: 10.3389/fimmu.2023.1125984.

  2. De Tapia L, García-Fojeda B, Kronqvist N, Johansson J, Casals C* (2022) The collectin SP-A and its trimeric recombinant fragment protect alveolar epithelial cells from the cytotoxic and proinflammatory effects of human cathelicidin in vitro. Front Immunol, 13:994328. doi: 10.3389/fimmu.2022.994328. (IF: 8.786).PubMed PDF

  3. Coya JM‡, Fraile-Ágreda V‡, de Tapia L, García-Fojeda B, Sáenz A, Bengoechea JA, Kronqvist N, Johansson J, Casals C* (2022) Cooperative action of SP-A and its trimeric recombinant fragment with polymyxins against Gram-negative respiratory bacteria. Front Immunol. 13:927017. doi: 10.3389/fimmu.2022.927017 (IF: 8.786).PubMed PDF

  4. García-Fojeda B‡, Minutti CM‡, Montero-Fernández C, Stamme C, Casals C* (2022) Signaling Pathways That Mediate Alveolar Macrophage Activation by Surfactant Protein A and IL-4. Front Immunol. 13:860262. doi: 10.3389/fimmu.2022.860262.  (IF: 8.786).PubMed PDF

  5. Cañadas O, Alejandra Sáenz, A, de Lorenzo, A., Casals, C*. (2022) Pulmonary surfactant inactivation by β‐D‐glucan and protective role of surfactant protein A. Colloids and Surfaces B-Biointerfaces 210:112237. Doi: 10.1016/j.colsurfb.2021.112237 (IF: 5.268).PubMed PDF

  6. Carregal-Romero S‡, Groult H‡, Cañadas O, A-Gonzalez N, Lechuga-Vieco AV, García-Fojeda B, Herranz F, Pellico J, Hidalgo A, Casals C*, Ruiz-Cabello J*. (2022) Delayed alveolar clearance of nanoparticles through control of coating composition and interaction with lung surfactant protein A. Biomater Adv. 134:112551. doi: 10.1016/j.msec.2021.112551 (IF: 7.328). Pubmed PDF

  7. Fraile-Ágreda V, Cañadas O, Weaver TE, Casals C*. (2021) Synergistic Action of Antimicrobial Lung Proteins against Klebsiella pneumoniae. International Journal of Molecular Sciences, 22:11146. Doi: 10.3390/ijms222011146 (IF: 6.2). PubMed PDF

  8. Casals, C*., García-Fojeda, B., Minutti, C.M. (2019) Soluble defense collagens: Sweeping up immune threats. Molecular Immunology, 112: 291-304. Doi: 10.1016/j.molimm.2019.06.007  (IF: 4.407).PubMed PDF

  9. García-Fojeda B, González-Carnicero Z, De Lorenzo A, Minutti CM, de Tapia L, Euba B, Iglesias-Ceacero A, Castillo-Lluva S, Garmendia J, J., Casals, C* . (2019) Lung surfactant lipids provide immune protection against haemophilus influenzae respiratory infection. Frontiers in Immunology, 10: 458. Doi: 10.3389/fimmu.2019.00458 (IF: 5.085). PubMed PDF

  10. Cañadas O, Casals C*. Differential Scanning Calorimetry of Protein-Lipid Interactions. Methods Mol Biol. 2019, 2003:91-106. doi: 10.1007/978-1-4939-9512-7_5. PubMed PDF

  11. Casals C*, Campanero-Rhodes MA, García-Fojeda B, Solís D*. The Role of Collectins and Galectins in Lung Innate Immune Defense. Front Immunol. 2018, 4;9:1998. doi: 10.3389/fimmu.2018.01998. Review. PubMed PDF

  12. Martínez-Florensa M, Català C, Velasco-de Andrés M, Cañadas O, Fraile-Ágreda V, Casadó-Llombart S, Armiger-Borràs N, Consuegra-Fernández M, Casals C, Lozano F. Conserved Bacterial-Binding Peptides of the Scavenger-Like Human Lymphocyte Receptor CD6 Protect From Mouse Experimental Sepsis. Front Immunol. 2018, 12;9:627. doi: 10.3389/fimmu.2018.00627. PubMed PDF

  13. Minutti C.M., Jackson-Jones L.H.#, García-Fojeda B.#, Knipper JA, Sutherland TE, Logan N., Rinqvist E., Guillamat-Prats R., Ferenbach DA, Artigas A., Stamme C., Chroneos Z.C., Zaiss D.M., Casals C.*, Allen J.E.* Local amplifiers of IL-4Ralpha-mediated macrophage activation promote repair in lung and liver. (#) these authors contributed equally to this work.; (*) corresponding authors. Science, 2017 356:1076-1080. Doi: 10.1126/science.aaj2067. PubMed PDF  Supplementary materials PDF  Commentary on our paper in SciencePDF

  14. Martínez I, Oliveros JC, Cuesta I, de la Barrera J, Ausina V, Casals C, de Lorenzo A, García E, García-Fojeda B, Garmendia J, González-Nicolau M, Lacoma A, Menéndez M, Moranta D, Nieto A, Ortín J, Pérez-González A, Prat C, Ramos-Sevillano E, Regueiro V, Rodriguez-Frandsen A, Solís D, Yuste J, Bengoechea JA, Melero JA. Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens. Front Microbiol. 8:276, 2017. doi: 10.3389/fmicb.2017.00276. PubMed PDF

  15. Ruge C., Hillaireau H., Grabowski N., Beck-Broichsitter M., Cañadas O., Tsapis N., Casals C., Nicolas J., Fattal E. Pulmonary surfactant protein A–mediated targeting of alveolar macrophages using mannosylated polymeric nanoparticles. Mol. Pharmacol 2017 13(12):4168-4178, 2016 (DOI: 10.1021/acs.molpharmaceut.6b00773).PubMed PDF

  16. Minutti C.M‡, García-Fojeda B‡, Saenz A., De Las Casas-Engel M., Guillamat-Prats R., De Lorenzo A.,Serrano-Mollar A., Corbí A.L., Casals C*. Surfactant protein A prevents IFN-gamma/IFN-gammaR interaction and attenuates classical activation of human alveolar macrophages. Journal of Immunology 197(2):590-598, 2016.PubMed PDF

  17. Coya J.M., Akinbi H., Saenz A, Yang L., Weaver T., Casals C*. Natural anti-infective pulmonary proteins: In vivo cooperative action of surfactant protein SP-A and the lung antimicrobial peptide SP-BN. Journal of Immunology, 195 (4), 1628-1636, 2015.PubMed PDF

  18. Saenz A, Presto J, Lara P, Akinyi-Oloo L, García-Fojeda B, Nilsson I, Johansson J, Casals C*. Folding and Intramembraneous BRICHOS Binding of the Prosurfactant Protein C Transmembrane Segment. J Biol Chem. 290(28):17628-17641,2015.PubMed PDF

  19. Martínez-Florensa M, Consuegra-Fernández M, Martínez VG, Cañadas O, Armiger-Borràs N, Bonet-Roselló L, Farrán A, Vila J, Casals C, Lozano F. Targeting of Key Pathogenic Factors From Gram-Positive Bacteria by the Soluble Ectodomain of the Scavenger-Like Lymphocyte Receptor CD6. J Infect Dis., 209(7):1077-1086, 2014. doi: 10.1093/infdis/jit624. PubMed PDF

  20. Izquierdo-García JL, Naz S, Nin N, Rojas Y, Erazo M, Martínez-Caro L, García A, de Paula M, Fernández-Segoviano P, Casals C, Esteban A, Ruíz-Cabello J, Barbas C, Lorente JA. A Metabolomic Approach to the Pathogenesis of Ventilator-induced Lung Injury. Anesthesiology, 120(3):694-702, 2014. doi: 10.1097/ALN.0000000000000074. PubMed PDF

  21. Cañadas O, Casals C*. Differential scanning calorimetry of protein-lipid interactions. Methods Mol Biol. 974:55-71, 2013. PubMed PDF

  22. Monforte V, López-Sánchez A, Zurbano F, Ussetti P, Solé A, Casals C, Cifrian J, de Pablos A, Bravo C, Román A. Prophylaxis with nebulized liposomal amphotericin B for Aspergillus infection in lung transplant patients does not cause changes in the lipid content of pulmonary surfactant. J Heart Lung Transplant. 32(3):313-319,2013. PubMed PDF

  23. Ruge CA, Schaefer UF, Hermann J, Kirch J, Cañadas O, Echaide M, Perez-Gil J, Casals C, Müller R, Lehr CM. The Interplay of Lung Surfactant Proteins and Lipids Assimilates the Macrophage Clearance of Nanoparticles. PloS One, 7 (7), e40775, 2012. PubMedPDF

  24. Casals C*, Cañadas O. Role of lipid ordered/disordered phase coexistence in pulmonary surfactant function. BBA-Biomembranes1818, 2550-2562, 2012. PubMedPDF

  25. Willander H, Askarieh G, Landreh M, Westermark P, Nordling K, Keränen H,Hermansson E, Hamvas A, Nogee LM, Bergman T, Saenz A, Casals C, Åqvistg J, Jörnvall H, Berglund H, Presto J, Knight SD, Johansson J. High-resolution structure of a BRICHOS domain and its implications for anti-amyloid chaperone activity on lung surfactant protein C. Proc Natl Acad Sci U S A, 109(7):2325-2329, 2012.PubMedPDF

  26. Ruge CA, Kirch J, Cañadas O, Schneider M, Perez-Gil J, Schaefer UF, Casals C, Lehr CM. Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A. Nanomedicine, 7(6):690-693, 2011.PubMedPDF

  27. Saenz A, L. Alvarez, M. Santos, A. Lopez-Sanchez, J.L. Castillo-Olivares, A. Varela, R. Segal and C. Casals*. Beneficial effects of synthetic KL4-surfactant in experimental lung transplantation. European Respiratory Journal, 37(4):925-32, 2011. PubMedPDF

  28. Lopez-Sanchez A., Sáenz A., and Casals C*. Surfactant protein A (SP-A)-tacrolimus complexes have a greater anti-inflammatory effect than either SP-A or tacrolimus alone on human macrophages-like U937 cells. European Journal of Pharmaceutics and Biopharmaceutics,77(3):384-391 2011.PubMedPDF

  29. Cañadas O., Keough K.M.W., and Casals C*. Lipopolysaccharide-promoted destabilization of lung surfactant-like monolayers. Biophysical J, 100, 108-116, 2011. PubMedPDF

  30. Askarieh G, Hedhammar M, Nordling K, Saenz A, Casals C, Rising A, Johansson J, Knight SD. Self-assembly of spider silk proteins is controlled by a pH-sensitive relay. Nature 465 (7295):236-238, 2010. PubMedPDF  Difusión: Tribuna Complutense-2010 PDF

  31. Landreh M, Askarieh G, Nordling K, Hedhammar M, Rising A, Casals C, Astorga-Wells J, Alvelius G, Knight SD, Johansson J, Jörnvall H, Bergman T. A. pH-Dependent Dimer Lock in Spider Silk Protein. J. Mol. Biol. 404(2):328-36, 2010. PubMedPDF

  32. Saenz A, Lopez-Sanchez A., Mojica-Lazaro J, Martinez-Caro L, Nin N., Bagatolli LA, Casals C*. Fluidizing Effects of C-Reactive Protein on Lung Surfactant Membranes: Protective Role of Surfactant Protein A.” FASEB J. 24(10), 3662-3673, 2010PubMedPDF

  33. Orgeig S, Hiemstra PS, Veldhuizen EJ, Casals C, Clark HW, Haczku A, Knudsen L, Possmayer F. Recent advances in alveolar biology: Evolution and function of alveolar proteins. Respir Physiol Neurobiol 173, Suppl:S43-54, 2010, Review. PubMed  PDF  

  34. Vera J, Fenutría R, Cañadas O., Figueras M, Mota R, Sarrias MR, Williams DL, Casals C., Yélamos J, & Lozano F. The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome. Proc. Natl. Acad. Sci. U.S.A., 106 (5),1506-1511, 2009.PDF. Commentary on our paper by Laurel L. Lenz in the same issue of PNAS (pages 1303-1304). PDF

  35. Cañadas O., García-Verdugo I., Keough K.M.W., Casals C*. SP-A permeabilizes lipopolysaccharide membranes by forming aggregates that extract lipids from the membrane. Biophysical J., 95 (7), 3287-3294, 2008. PDF

  36. Casals C*, Johansson H, Saenz A., Gustafsson M, Alfonso C, Nordling K, Johansson J. C-terminal, endoplasmic reticulum-lumenal domain of prosurfactant protein C -Structural features and membrane interactions. FEBS J. 275(3), 536-547, 2008. PDF

  37. Hedhammar M, Rising A, Grip S, Saenz-Martinez A., Nordling K, Casals C., Stark M, Johansson J. Structural Properties of Recombinant Nonrepetitive and Repetitive Parts of Major Ampullate Spidroin 1 from Euprosthenops australis: Implications for Fiber Formation. Biochemistry. 47(11):3407-3417, 2008. PDF

  38. Solaz-Fuster, M.C., Gimeno-Alcañiz, J.V., Ros, S., Fernández-Sanchez, M.E., García-Fojeda, B., Criado García, O., Vílchez, D., Domínguez, J., García-Rocha, M., Sánchez-Piris, M, Aguado, C., Knecht, E., Serratosa, J.M., Guinovart, J., Sanz, P., Rodríguez de Córdoba, S. Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway. Human Molecular Genetics 17(5), 667-78,2008.PDF

  39. García-Verdugo I., Cañadas O., Taneva S.G., Keough K.M.W., Casals C*. SP-A forms extensive lattice-like structures on DPPC/rough-lipopolysaccharide mixed monolayers. Biophysical J., 93 (10), 3529–3540, 2007. PDF

  40. Sarrias M.R., Farnos M., Mota R., Sanchez-Barbero F., Ibanez A., Gimferrer I., Vera J., Fenutria R., Casals C., Yelamos J., Lozano F. CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock. Proc Natl Acad Sci U S A. 104,11724-11729, 2007. PDF

  41. Sanchez-Barbero F., Rivas G., Steinhilber W., Casals C. Structural and functional differences among human surfactant proteins SP-A1, SP-A2, and coexpressed SP-A1/SP-A2. Role of supratrimeric oligomerization. Biochem J., 406 (3), 479-489, 2007. PDF

  42. Sáenz A., Cañadas O., Bagatolli L.A., Sánchez-Barbero F., Johnson M.E., Casals, C*. Effect of surfactant protein A (SP-A) on the physical properties and surface activity of KL4-surfactant. Biophys. J. 92(2), 482-492, (2007). PDF

  43. Vílchez, D., Ros, S., Cifuentes, D., Pujadas, L., Vallés, J., García-Fojeda, B., Criado-García, O., Fernández-Sanchez, E., Medraño, I., Domínguez, J., García-Rocha, M., Soriano, E., Rodríguez de Córdoba, S. and Guinovart, J. (2007). Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy. Nature Neuroscience 10(11), 1407-13, 2007.PDF

  44. Sáenz A., Cañadas O., Bagatolli L.A., Johnson M.E., Casals, C*. Physical properties and surface activity of surfactant-like membranes containing the cationic and hydrophobic peptide KL4. FEBS J. 273, 2515–2527, 2006. PDF

  45. Sánchez-Barbero F., Strassner J., García-Cañero R., Steinhilber W., Casals C*. Role of the Degree of Oligomerization in the Structure and Function of Human Surfactant Protein A. J. Biol. Chem. 280, 7659–7670, 2005. PDF

  46. Sarrias MR, Rosello S, Sanchez-Barbero F., Sierra JM, Vila J, Yelamos J, Vives J, Casals C., Lozano F. A role for spalpha as a pattern-recognition receptor. J Biol. Chem. 280, 35391–35398, 2005. PDF

  47. García-Verdugo I, Sánchez-Barbero F., Soldau K, Tobias P.S., Casals C*. Interaction of surfactant protein A (SP-A) with bacterial rouge lipopolysaccharide (Re-LPS) and effects of SP-A on the binding of Re-LPS to CD14 and LPS binding protein. Biochem. J. 391, 115-124, 2005.PDF

  48. Cañadas O., Sáenz A., Orellana G., Casals C*. Equilibrium studies of a fluorescent tacrolimus binding to surfactant protein A. Anal. Biochem. 340, 57–65, 2005. PDF

  49. C. Casals* and I. García-Verdugo. Molecular and functional properties of surfactant protein A. In Developements In Lung Surfactant Dysfunction" In Lung Biology In Health And Disease. (Ed.: K. Nag). Chapter 3, pp 57-84, Marcel Dekker Inc., New York. (2005) (ISBN: 0-8247-5792-0). PDF

  50. Cañadas O., Guerrero R., García-Cañero R.,Orellana, G., Menéndez M., Casals C*. Characterization of liposomal FK506 in lung surfactant-like phospholipids and evaluation of its immunosuppressive activity. Biochemistry 43, 9926-9938, 2004. PDF

  51. Valiño F., Casals C*, Guerrero R., Álvarez L., Santos M., Varela A.,Sáenz A., Claro MA, Tendillo F, Castillo-Olivares J.L. Inhaled Nitric Oxide Affects Endogenous Surfactant in Experimental Lung Transplantation.Transplantation 77,812-818, 2004. PDF

  52. Casals C*, Arias-Díaz J., Valiño F., Sáenz A., García C., Balibrea J.L., Vara E. Surfactant strengthens the inhibitory effect of C-reactive protein on human lung macrophage-cytokine release. Am. J. Physiol. Lung Cell. Mol. Physiol. 284, 466-472, 2003. PDF

  53. García-Verdugo I, Sánchez-Barbero F., Bosch F.U., Steinhilber W., Casals C*. Effect of hydroxylation, oligomerization, and N187-linked glycosylation on structural and biochemical properties of recombinant human SP-A1. Biochemistry 42, 9532-9542, 2003. PDF

  54. Fernández-Sánchez, M.E., Heath, K., Criado-García, O., García-Fojeda, B., Medraño-Fernández, I., Gomez-Garre, P., Sanz, P., Serratosa, J. M. and de Córdoba, S.R. Laforin, the dual-phosphatase responsible for lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation. Human Molecular Genetics 12(23):3161-71, 2003. 

  55. García-Verdugo I, Guirong G., Floros J., and Casals C*. Structural analysis and lipid binding properties of recombinant human surfactant protein A (SP-A) derived from one (SP-A1 OR SP-A2) or both genes. Biochemistry 41, 14041-14053, 2002. PDF

  56. Casals C*. Role of surfactant protein A (SP-A)/lipid interactions for SP-A functions in the lung. Pediatr. Pathol. Mol. Med. 20, 249-68., 2001 Review. PDF

  57. Plasencia I, Cruz A, Casals C., and Perez-Gil J. Superficial disposition of the N-terminal region of the surfactant protein SP-C and the absence of specific SP-B-SP-C interactions in phospholipid bilayers. Biochem. J. 359, 651-659, 2001. PDF

  58. Plasencia I, Cruz A, Lopez-Lacomba Jl, Casals C., and Perez-Gil J. Selective labeling of pulmonary surfactant protein SP-C in organic solution. Anal. Biochem. 296, 49-56, 2001. PDF

  59. Oviedo JM, Valino F, Plasencia I, Serrano AG, Casals C., and Perez-Gil J. Quantitation of pulmonary surfactant protein SP-B in the absence or presence of phospholipids by enzyme-linked immunosorbent assay. Anal. Biochem. 293, 78-87, 2001. PDF

  60. Plasencia I, Rivas L, Casals C., Keough KMW, and Perez-Gil J. Intrinsic structural differences in the N-terminal segment of pulmonary surfactant protein SP-C from different species. Comp. Biochem. Physiol. A 129, 129-39, 2001. PDF

  61. Oviedo JM, Casals C., and Perez-Gil J. Pulmonary surfactant protein SP-B is significantly more immunoreactive in anionic than in zwitterionic bilayers. FEBS Lett. 494, 236-240, 2001. PDF

  62. Ruano, M.L.F., García-Verdugo, I., Miguel, E., Pérez-Gil, J., and Casals C*. Self-aggregation of surfactant protein A. Biochemistry 39, 6529-6537, 2000. PDF

  63. Cruz, A., Wothman, L.A., Serrano, A.G., Casals, C., Keough, KMW., and Perez-Gil, J. Microstructure and dynamic surface properties of surfactant protein SP-B/DPPC interfacial films spread from lipid/protein bilayers. Eur J Biophys 29, 204-213, 2000. PDF

  64. Worthman, L. D., Nag, K., Rich, N., Ruano, M.L.F., Casals, C., Pérez-Gil., J., Keough K.M.W. Pulmonary surfactant protein A interacts with gel-phase regions in monolayers of pulmonary surfactant lipid extract. Biophys. J. 79, 2657-2666, 2000. PDF

  65. Casals, C*. Studies on SP-A/lipid interactions. Applied Cardiopulmonary Pathophysiology 9, 204-207, 2000. 

  66. Arias-Diaz, J., García-Verdugo, I., Casals, C., Sánchez-Rico, N., Vara, E., and Balibrea, J.L. Effect of surfactant protein A (SP-A) on the production of cytokines by human alveolar macrophages. Shock 14, 300-306, 2000. PDF

  67. Ruano, M.L.F., Nag, K. Casals, C., Pérez-Gil, J., and Keough, K.M.W. Interactions of pulmonary surfactant protein A with phospholipid monolayers change with pH. Biophys. J. 77, 1469-1476, 1999. PDF

  68. Casals C*, Varela A., Ruano M.L.F., Valiño F., Pérez-Gil J., Torre N., Jorge E., Tendillo F., And Castillo-Olivares J.L. Increase of C-reactive protein and decrease of surfactant apolipoproteins SP-A and SP-B in surfactant after lung transplantation. Am. J. Respir. Crit. Care Med., 157, 43-47, 1998.PDF

  69. F. Valiño, L. Álvarez, M. Santos, M.L.F. Ruano, A. Varela, J. Pérez-Gil, J.L. Castillo-Olivares, and C. Casals*. Evaluation of aerosolized surfactant treatment in lung transplantation. Rev. R. Acad. Cienc. Exact. Fis. Nat. (Esp) 92, 229-236, 1998. 

  70. Ruano M.L.F., Pérez-Gil J., and Casals C*. Effect of acidic pH on the structure and lipid binding properties of surfactant protein A: potential role of acidification along its exocytic pathway. J Biol. Chem. 273, 15183-15191 1998. PDF

  71. Ruano M.L.F., Kaushik N., Worthman L., Casals C., Pérez-Gil J., and Keough K.M.W. Diferencial partitioning of pulmonary surfactant protein SP-A into regions of monalayers of dipalmitoylphosphatidylcholine (DPPC) and DPPC/ dipalmitoylphosphatidylglycerol. Biophys. J. 74, 1101-1109, 1998. PDF

  72. Nag K., Pérez-Gil J., Ruano M.L.F., Stewart J., Casals C., and Keough K. Transitions in films of lung surfactant at the air-water interface. Biophys. J. 74, 2983-2995,1998. PDF

  73. Cruz A., Casals C., Plasencia I., Marsh D., Pérez-Gil J. Insertion modes of pulmonary surfactant protein SP-B in phosphatidylcholine bilayers studied by fluorescence and electrom spin resonance spectroscopy. Biochemistry. 37, 9488-9496, 1998. PDF

  74. Cruz A., Casals C., Keough K.M.W, and Perez-Gil J. Different modes of interation of pulmonary surfactant protein SP-B in phosphatidylcholine bilayers.  Biochem J., 327, 133-138, (1997).

  75. Van Golde L.M.G. and Casals C. Metabolism of Lipids by the Lung. In The Lung: Scientific Fundations, (Ed.:Crystal RG, West JB, Barnes PJ, Weibel ER),  2º Ed., Ch: 2, pp: 9-18, Lippincott-Raven, (New York) (USA) (1997). (ISBN 0-397-51632-0).

  76. Pérez-Gil J., Cruz A., Ruano M.L.F., Miguel E., Plasencia I.,and Casals C. Interaction of pulmonary surfactant-associated proteins with phospholipid vesicles. In Molecular Dinamics of Biomembranes (J.A.F. Op den Kamp, Ed.). NATO ASI Series; Vol H 96, 399-406, Springer-Verlag, Berlin (1996). (ISNB 3-540-060764-1).

  77. Ruano M.L.F., Miguel E., Perez-Gil J., and Casals C*. Comparison of vesicle aggregation and self-aggregation activities of pulmonary surfactant associated-protein A. Biochem. J. 313, 683-689, (1996).

  78. Camacho L., Cruz A., Castro R., Casals C., and Perez-Gil J. Effect of pH on the interfacial adsorption activity of pulmonary surfactant.  Colloids Surf. B. Biointer. 5, 271-277, (1996).

  79. Perez-Gil J., Casals C., and Marsh D. Interactions of hydrophobic lung surfactant proteins SP-B and SP-C with dipalmitoylphosphatidylglycerol bilayers studied by electron spin resonance (ESR) spectroscopy.  Biochemistry 34, 3964-3971, (1995).

  80. Cruz A., Casals C., and Perez-Gil J. Conformational flexibility of pulmonary surfactant proteins SP-B and SP-C, studied in aqueous organic solvents.  Biochim. Biophys. Acta 1255, 68-76, (1995).

  81. Casals C*, Miguel E., Perez-Gil, J., and Fernandez-Ruano M.L. Vesicle aggregation induced by SP-A occurs in an ionic strength dependent manner.  In: Lung Surfactant: Basic Research in the Pathogenesis of Lung Disorders (Ed.: P. von Wichert & B. Müller). Progress in Respiratory Reseach, Vol 27, 39-43, Karger,  Switzzerland, (1994). (ISBN 3-8055-5837-6). CL

  82. Casals C*, Ruano, M.L.F., Miguel E., Sanchez P., and Perez-Gil J. Surfactant protein-C enhances lipid aggregation activity of surfactant protein-A.  Biochem. Soc. Trans., 22, 370S, (1994).

  83. Miguel E., Casals C., and Perez-Gil, J. Effect of the nature of the polar head group of phospholipids on lipid/SP-A interaction. In: Lung Surfactant: Basic Research in the Pathogenesis of Lung Disorders(Ed.: P. von Wichert & B. Müller). Progress in Respiratory Reseach, Vol  27, 33-38, Karger,  Switzzerland (1994). (ISBN 3-8055-5837-6).

  84. Perez-Gil J., Lopez-Lacomba J.L., Cruz A., Beldarrain A., and Casals C. Deacylated pulmonary surfactant protein SP-C has different effects on the thermotropic behaviour of bilayers of dipalmitoylphosphatidylglycerol (DPPG) than the native acylated protein.  Biochem. Soc. Trans., 22, 372S, (1994).

  85. Varela A., Montero C.G., Casals C., Perez-Gil J., Tendillo F.J., Jorge E., Torre N., Mascias A., Santos M., Serrano-Fiz S., Burgos R., Daroca T., Tebar E., Tellez G., Peñalver R., Ugarte J., Castillo-Olivares J.L. Retrograde lung preservation improves lung function after transplantation.  Transplantology 5, 90-93, (1994).

  86. Perez-Gil J., Casals C., and Marsh D. Lipid-protein interactions with the hydrophobic SP-B and SP-C lung surfactant proteins in dipalmi­toylphosphatidylcholine bilayers. In Biological Membranes: Structure, Biogenesis and Dynamics ( Ed.: JAF Op den Kamp), NATO ASI Series, Vol  H 82, 93-100, Springer-Velag, New York, (1994). (IBSN 0-387-57731-9).

  87. Perez-Gil J., Cruz A., and Casals C*. Structural features of porcine SP-B and SP-C in organic solvent/water mixtures. A system model to approach the study of hydrophobic surfactant-associated proteins. Lung Surfactant: Basic Research in the Pathogenesis of Lung Disorders(Ed.: P. von Wichert & B. Müller). Progress in Respiratory Reseach, Vol 27, 58-61, Karger,  Switzzerland, (1994). (ISBN 3-8055-5837-6).

  88. Casals C*, Miguel E., and Perez-GIL J. Tryptophan fluorescence study on the interaction of pulmonary surfactant protein A (SP-A) with phospholipid vesicles.  Biochem. J., 296, 585-593, (1993).

  89. Perez-Gil J., Cruz A., and Casals C*. Studies on solubility and structure of hydrophobic surfactant-associated proteins, SP-B and SP-C from pig lung, in organic solvent/water mixtures.  Biochim. Biophys. Acta, 1168, 261-270, (1993).

  90. Van Golde L.G.M., and Casals C. Metabolism of lipids. In The Lung: Scientific Fundations (Crystal RG & West JB,  Ed.) Ch: 2.3, pp 25-31, Raven  Press, (New York) , (1991). (ISBN 0-88167-629-2).

  91. Casals C*, Herrera L., Garcia-Barreno P., and Municio A.M. Association of changes in lisophosphatidylcholine metabolism and in microsomal membrane lipid composition to pulmonary injury induced by oleic acid.  Biochim. Biophys. Acta, 1023, 290-297, (1990).

  92. Casals C*, Herrera L., Miguel E., Garcia-Barreno P., and Municio A.M. Biphasic response of dipalmotoylphosphatidylcholine content to respiratory distress induced by oleic acid.  In: Basic Research on Lung Surfactant (Ed.: P. von Wichert & B. Müller). Progress in Respiratory Reseach, Vol  25, 338-342, Karger, Switzzerland, (1990). (ISBN 3-8055-5030-8).

  93. Casals C*, Herrera L., Miguel E., Garcia-Barreno P.,  and Municio A.M. Comparison between intra- and extra-cellular surfactant in respiratory distress induced by oleic acid.  Biochim. Biophys. Acta, 1003, 201-203, (1989).

  94. Casals C*, Herrera L., Gasset M., Garcia-Barreno P., and Municio A.M. Microsomal membrane fluidity and phosphatidylcholine synthesis in rabbit lung under high oxygen tension.  Cell. Biochem. Function, 7, 193-199, (1989).

  95. Casals C*, Herrera L., Miguel E., Garcia-Barreno P., and Municio A.M. Changes in lipid fluidity and composition  of lamelar bodies in respiratory distress induced by oleic acid.  Biochem. Soc. Trans.,17, 792-794, (1989).

  96. Schlame M., Casals C., Rustow B., Rabe H., and Kunze D. Molecular species of phosphatidylcholine and phosphatidylglycerol in rat lung surfactant and pneumocytes type II.  Biochem. J., 253, 209-215, (1988).

  97. Casals C*, Gasset M., Mendez C., Garcia-Barreno P., and Municio A.M. Lipid alterations in liver and kidney induced by normobaric hyperoxia. Correlations with changes in microsomal membrane fluidity.  Biochem. Med. Met. Biol., 37, 269-281, (1987).

  98. Casals C*, Herrera L., Gasset M., Garcia-Barreno P., and Municio A.M. Glycerolipid metabolism in lung from ventilated and unventilated rabbits.  Biochem. Int., 12, 757-766, (1986).

  99. Casals C*, Maquedano A., Olive M., Guzman M., and Castro J. Differences in glycerolipid synthesis and insulin regulation in rat hepatocytes and adipocytes.  Biochem. Int., 13, 501-509, (1986).

  100. Casals C*, Herrera L., Soriano Y., Garcia-Barreno P., and Municio A.M. Membrane regulation of liver and lung microsomes under low oxygen tension.  Biochem. Biophys. Res. Commun., 126, 551-558, (1985).

  101. Casals C*, Acebal C., Perez J., and Arche R. Effect of lipids on activity and conformation of lysolecithin:lysolecithin acyltransferase from rabbit lung.  Mol. Cell. Biochem., 63, 13-20, (1984).

  102. Casals C*., Acebal C., and Arche R. Substrate selectivity oflysophosphatidylcholine: lysophosphatidylcholine from rabbit lung.  Int. J. Biochem., 16, 773-778, (1984).

  103. Arche R., Acebal C., Casals C., Estrada P., and Herrera L. Lysolecithin:lysolecithin acyltransferase from rabbit lung: A conformational study.  J. Pep. Prot. Res., 23, 487-493, (1984).

  104. Estrada P., Acebal C., Bauluz C., Casals C., and Arche R. Influence of temperature on stability and activity of lysolecithin acyltransferase.  Biochem. Int., 8, 339-346, (1984).

  105. Casals C., Garcia-Barreno P., and Municio A.M. Lipogenesis in liver, lung and adipose tissue of rats fed with oleoylanilide.  Biochem. J., 212, 339-344, (1983).

  106. Casals C. Metabolismo del Surfactante Pulmonar durante el Desarrollo Fetal. En Avances en el Laboratorio Médico (Editores: Fernández Chacón JL, Gasalla Chacón R, Gómez Mantilla JM, Gutiérrez Altes A, y  Montero M), Ch:3, pp. 31-48, (1983) (ISBN 84-398-0482).

  107. Casals C., Acebal C., Cruz-Alvarez M., Estrada P. and Arche R. Lysolecithin:lysolecithin acyltransferase from rabbit lung. Enzymatic properties and kinetic study.  Arch. Biochem. Biophys., 217, 422-433, (1982).

  108. Acebal C., Arche R., Casals C., Castro J., and RODRIGUEZ S. Biosynthesis of phosphatidic acid by liver and lung of maternal and fetal rabbits.  Int. J. Biochem. 10, 463-467, (1979).