Research Projects

PID2021-123044OB-I00 (2023-2025). Exploring new therapies by understanding the role of the alveolar niche in lung resistance to infection and inflammation. Funded by Spanish Ministry of Science and Innovation. PI: Cristina Casals.

RTI2018-094355-B-I00 (2019-2021). Tissue-specific signals that modulate type 2. responses in alveolar macrophages in health and disease. Funded by Spanish Ministry of Science, Innovation and Universities. PI: Cristina Casals.

SAF2015-65307-R (2016-2018). Natural anti-infective factors of the lung as new therapeutic strategies against respiratory infections. Funded by Spanish Ministry of Economy and Competitiveness. PI: Cristina Casals.

SAF2012-32728 (2013-2015). Lung surfactant as protector and modulator of lung infection and inflammation. Funded by Spanish Ministry of Economy and Competitiveness. PI: Cristina Casals.

SAF2009-07810.(2010-2012). Protective effects of pulmonary surfactant components on lung host defense and lung inflammation. Funded by Spanish Ministry of Science and Innovation. PI: Cristina Casals.

CB06/06/0002. (2007-2021) CIBER de Enfermedades Respiratorias. Funded by Instituto de Salud Carlos III. Projects: 1)Toward improving the clinical management of respiratory infectious diseases by host-pathogen interplay innovative research (2019/21); 2) Integrative network genomics approach to address molecular differences and commonalities in COPD and IPF (2018/19); 3) Overcoming Respiratory infections through exploitation of pathogen and host-directed novel Therapeutics (2016/18); 4) Respiratory infections: from mechanisms to therapeutics (2013/15).(8 research groups) PI (UCM): Cristina Casals.

Technological Research Project Contract (Art. 83 L.O.U. 425-2007) (2009-2011). Immunomodulatory properties of a synthetic lung surfactant based on rSP-C. Funded by Nycomed GmbH (konstanz, DE). PI: Cristina Casals.

S2006/BIO-0260 (2007-2010). Novel targets to combat bacterial pathogens. Programs of R&D Activities Between Research Groups of the Autonomous Community of Madrid in Biosciences Funded by Funded by Autonomous Community of Madrid (Spain). Project Coordinator: Miguel Vicente Muñoz (CNB). PI(UCM): Cristina Casals.

SAF2006-04434 (2007-2009). Role of lipid-protein interactions in the lung response to injury. Funded by Spanish Ministry of Education and Science. PI: Cristina Casals.

PI030137-FIS (2004-2006). Therapeutic efficacy of KL4-liposomal amphipathic peptide (Surfaxin) in the presence or absence of surfactant protein SP-A. In vitro and in vivo studies in experimental lung transplantation”. Funded by  Health Research Fund from Carlos III Health Institute.

Art. 83 L.O.U (2005-2008). Lipid-protein interactions in pulmonary surfactant. Funded  by  “Fundación Médica MM” (Madrid). Principal Investigator: Cristina Casals.

Technological Research Contract (2003-2006). Evaluation of KL4-Surfactant. Funded by Dr. Esteve Laboratories, S.A. (Barcelona, ES) and  Discovery Laboratories, Inc (Philadelphia, USA). PI: Cristina Casals.

Technological Research Contract (Art. 11 L.R.U. 299-2001) (2002-2005). Potential Anti-Inflammatory Properties of liposomal Tacrolimus (FK 506). Funded by Fujisawa GmbH (Munich, DE). PI: Cristina Casals.

QLK2-2000-00325 (2000-2003). Control of lung infection, allergy and inflammation: assessment of the therapeutic potential of recombinant forms of the lung surfactant proteins SP-A and SP-D. Funded by European Commission. Project Coordinator: Prof. Dr. K. Reid (UK). PI (Spain): Cristina Casals

PB98-0769-C02-01 (1999-2002). Molecular Basis of the Interaction of Surfactant Protein SP-A with Different Ligands in the Alveolar Surface. Funded by Spanish Ministry of Science and Technology. PI and Project Coordinator: Cristina Casals.

CAM-08.3/0010.2/98 (1999-2000). Biochemical Evaluation of Different Therapies In Lung Transplantation. Funded by Autonomous Community of Madrid (Spain). PI: Cristina Casals.

FIS-96/1290 (1996-1998). “Exogenous Surfactant Therapy In Lung Transplantation”. Funded  by “Fondo de Investigación Sanitaria” (Spanish Ministry of Health). Principal Investigator: Cristina Casals.

PB92-0752 (1993-1995). “Molecular Characterization of the Lipid-protein Complex of Pulmonary Surfactant”. Funded  by “Dirección General de Investigación Científica Y Técnica” (Spanish Ministry of Science). Principal Investigator: Cristina Casals.

PM89-0039 (1990-1992). “Alteration of Pulmonary Surfactant In Adult Respiratory Distress Syndrome”. Funded  by “Dirección General De Investigación Científica Y Técnica” (Spanish Ministry of Science). Principal Investigator: Cristina Casals.

PR84-0490 (1986-1989). “Biochemical Aspects of Respiratory Pathology (Adult Respiratory Distress Syndrome)”. Funded  by “Dirección General de Investigación Científica Y Técnica” (Spanish Ministry of Science). Principal Investigator: Cristina Casals.