Genetic variants regulating the immune response improve the prediction of COVID-19 severity provided by clinical variables

Delgado-Wicke P, Fernández de Córdoba-Oñate S, Roy-Vallejo E, Alegría-Carrasco E, Rodríguez-Serrano DA, Lamana A, Montes N, Nicolao-Gómez A, Carracedo-Rodríguez R, Marcos-Jiménez A, Díaz-Fernández P, Galván-Román JM, Rabes-Rodríguez L, Sanz-Alba M, Álvarez-Rodríguez J, Villa-Martí A, Rodríguez-Franco C, Villapalos-García G, Zubiaur P, Abad-Santos F, de Los Santos I, Gomariz RP, García-Vicuña R, Muñoz-Calleja C, González-Álvaro I, Fernández-Ruiz E; PREDINMUN-COVID Group.

Sci Rep. 2024 Sep 5;14(1):20728. doi: 10.1038/s41598-024-71476-2. PDF

Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells

Castro-Vázquez D, Arribas-Castaño P, García-López I, Gutiérrez-Cañas I, Pérez-García S, Lamana A, Villanueva-Romero R, Cabrera-Martín A, Tecza K, Martínez C, Juarranz Y, Gomariz RP, Carrión M.

Biofactors. 2024 Nov-Dec;50(6):1148-1160. doi: 10.1002/biof.2062. PDF

VIP/VPAC Axis Expression in Immune-Mediated Inflammatory Disorders: Associated miRNA Signatures 

Lamana A, Castro-Vázquez D, de la Fuente H, Triguero-Martínez A, Martínez-Hernández R, Revenga M, Villanueva-Romero R, Llamas-Velasco M, Chicharro P, Juarranz Y, Marazuela M, Sales-Sanz M, García-Vicuña R, Tomero E, González-Álvaro I, Martínez C, Gomariz RP. 

Int J Mol Sci. 2022 Aug 2;23(15):8578. doi: 10.3390/ijms23158578. PDF

Human CD4⁺CD45RA⁺ T Cells Behavior after In Vitro Activation: Modulatory Role of Vasoactive Intestinal Peptide

Villanueva-Romero R, Cabrera-Martín A, Álvarez-Corrales E, Carrión M, Pérez-García S, Lamana A, Castro-Vázquez D, Martínez C, Gomariz RP, Gutiérrez-Cañas I, Juarranz Y. 

Int J Mol Sci. 2022 Feb 20;23(4):2346. doi: 10.3390/ijms23042346. PDF

The Neuropeptide VIP Limits Human Osteoclastogenesis: Clinical Associations with Bone Metabolism Markers in Patients with Early Arthritis

Castro-Vazquez D, Lamana A, Arribas-Castaño P, Gutiérrez-Cañas I, Villanueva-Romero R, Pérez-García S, Martínez C, Juarranz Y, Fernández de Córdoba S, González-Álvaro I, Gomariz RP, Carrión M. 

Biomedicines. 2021 Dec 10;9(12):1880. PDF

Proteomic Analysis of Synovial Fibroblasts and Articular Chondrocytes Co-Cultures Reveals Valuable VIP-Modulated Inflammatory and Degradative Proteins in Osteoarthritis

Pérez-García S, Calamia V, Hermida-Gómez T, Gutiérrez-Cañas I, Carrión M, Villanueva-Romero R, Castro D, Martínez C, Juarranz Y, Blanco FJ, Gomariz RP. 

Int J Mol Sci. 2021 Jun 16;22(12):6441. PDF

Comparative Study of Senescent Th Biomarkers in Healthy Donors and Early Arthritis Patients. Analysis of VPAC Receptors and Their Influence

Villanueva-Romero R, Lamana A, Flores-Santamaría M, Carrión M, Pérez-García S, Triguero-Martínez A, Tomero E, Criado G, Pablos JL, González-Álvaro I, Martínez C, Juarranz Y, Gomariz RP, Gutiérrez-Cañas I. 

Cells. 2020 Dec 4;9(12):2592. PDF

Editorial: GPCR in Inflammatory and Cancer Diseases

Couvineau A, Gomariz RP, Tan YV. 

Front Endocrinol (Lausanne). 2020 Sep 25;11:588157. PDF

Vasoactive intestinal peptide axis is dysfunctional in patients with Graves' disease

Carrión M, Ramos-Leví AM, Seoane IV, Martínez-Hernández R, Serrano-Somavilla A, Castro D, Juarranz Y, González-Álvaro I, Gomariz RP, Marazuela M. 

Sci Rep. 2020 Aug 3;10(1):13018. PDF

The multilayered complexity of the chemokine receptor system

D'Agostino G, García-Cuesta EM, Gomariz RP, Rodríguez-Frade JM, Mellado M. 

Biochem Biophys Res Commun. 2020 Jul 23;528(2):347-358. 

Identification of a Human SOCS1 Polymorphism That Predicts Rheumatoid Arthritis Severity

Lamana A, Villares R, Seoane IV, Andrés N, Lucas P, Emery P, Vital EM, Triguero-Martínez A, Marquez A, Ortiz AM, Maxime R, Martínez C, Martín J, Gomariz RP, Ponchel F, González-Álvaro I, Mellado M. 

Front Immunol. 2020 Jun 26;11:1336. PDF

Profile of Matrix-Remodeling Proeinases in Osteoarthritis: Impact of Fibronectin

Pérez-García S, Carrión M, Gutiérrez-Cañas I, Villanueva-Romero R, Castro D, Martínez C, González-Álvaro I, Blanco FJ, Juarranz Y, Gomariz RP. 

Cells. 2019 Dec 22;9(1):40. PDF

A Clinical Approach for the Use of VIP Axis in Inflammatory and Autoimmune Diseases

Martínez C, Juarranz Y, Gutiérrez-Cañas I, Carrión M, Pérez-García S, Villanueva-Romero R, Castro D, Lamana A, Mellado M, González-Álvaro I, Gomariz RP. 

Int J Mol Sci. 2019 Dec 20;21(1):65. PDF

An Overview of VPAC Receptors in Rheumatoid Arthritis: Biological Role and Clinical Significance

Gomariz RP, Juarranz Y, Carrión M, Pérez-García S, Villanueva-Romero R, González-Álvaro I, Gutiérrez-Cañas I, Lamana A, Martínez C. 

Front Endocrinol (Lausanne). 2019 Oct 22;10:729. PDF

The Adipokine Network in Rheumatic Joint Diseases

Carrión M, Frommer KW, Pérez-García S, Müller-Ladner U, Gomariz RP, Neumann E. 

Int J Mol Sci. 2019 Aug22;20(17):4091. PDF

Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients

Villanueva-Romero R, Gutiérrez-Cañas I, Carrión M, González-Álvaro I, Rodríguez-Frade JM, Mellado M, Martínez C, Gomariz RP, Juarranz Y. 

Sci Rep. 2019 May 14;9(1):7383. PDF

Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast-derived ADAMTS-7 and -12

Pérez-García S, Carrión M, Villanueva-Romero R, Hermida-Gómez T, Fernández-Moreno M, Mellado M, Blanco FJ, Juarranz Y, Gomariz RP. 

J Cell Mol Med. 2019 Jun;23(6):3974-3983. PDF

 

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