Publicaciones científicas

Publicaciones de los últimos 5 años:

Metagenomic symphony of the intestinal ecosystem: how the composition affects the mind
Stefanie Malan-Müller, David Martín-Hernández, Javier R. Caso, Jelle Matthijnssens, Amanda Rodriguez-Urrutia, Christopher A. Lowry, Juan C. Leza
Brain Behav Immun. 2025; 123:510-523
10.1016/j.bbi.2024.09.033 39368785

Impact of relapse in BDNF receptors expression in patients with a first episode of schizophrenia
M. Bioque, V. Llorca-Bofí, KS MacDowell, S. Amoretti, G. Mezquida, MJ Cuesta, C. M Diaz-Caneja, Á. Ibáñez, R. Segarra, A. González-Pinto, A. Roldán, PA. Sáiz, A. Mané, A. Lobo, A. Martínez-Pinteño, G. Cano-Escalera, E. Berrocoso, M. Bernardo
Schizophr Bull. 2025 Feb 20:sbaf012
10.1093/schbul/sbaf012 39977257

CX3CL1 Regulation of Gliosis in Neuroinflammatory and Neuroprotective Processes
Irene L. Gutiérrez, David Martín-Hernández, Karina S. MacDowell, Borja García-Bueno, Javier R. Caso, Juan C. Leza and José L. M. Madrigal
Int J Mol Sci, 2025, 26, 959
10.3390/ijms26030959 39940727

Chronic Stress dysregulates autophagy, membrane dynamics, and lysosomal status in frontal cortex and hippocampus of rats
C. Ulecia-Morón, AG. Bris, KS. MacDowell, P. Cerveró-García, JLM. Madrigal, B. García-Bueno, MP. Pereira, JC. Leza, JR Caso
Eur Neuropsychopharmacol. 2025

Differential regulation of innate immune system in frontal cortex and hippocampus in a “double-hit” neurodevelopmental model in rats
Álvaro G. Bris, Karina S. MacDowell, Cristina Ulecia-Morón, David Martín-Hernández, Beatriz Moreno, José L.M. Madrigal, Borja García-Bueno, Javier R. Caso, Juan C. Leza
Neurotherapeutics. 2024 Jan;21(1):e00300
10.1016/j.neurot.2023.10.010 38241165

Decreased oxytocin plasma levels and oxytocin receptor expression associated with aggressive behavior in aggressive-impulsive disorders
M Diaz-Marsá, J M López-Villatoro, A De la Torre-Luque, K S MacDowell, A Galvez-Merlin, A Gómez Del Barrio, F Ruiz-Guerrero, L Beato-Fernández, F Polo-Montes, M León-Velasco, D Martín-Hernández, A Carrasco-Diaz, JC Leza, J L Carrasco
J Psychiatr Res. 2024 Feb:170:200-206
10.1016/j.jpsychires.2023.12.032 38157667

Association between neutrophil to lymphocyte ratio and inflammatory biomarkers in patients with a first episode of psychosis
Bioque M, Llorca-Bofí V, Salmerón S, García-Bueno B, MacDowell KS, Moreno C, Sáiz PA, González-Pinto A, Hidalgo-Figueroa M, Barcones MF, Rodriguez-Jimenez R, Bernardo M, Leza JC
J Psychiatr Res. 2024 Apr;172:334-339
10.1016/j.jpsychires.2024.02.044 38437766

N-acetylcysteine during critical neurodevelopmental periods prevents behavioral and neurochemical deficits in the Poly I:C rat model of schizophrenia
Diego Romero-Miguel, Marta Casquero-Veiga, Nicolás Lamanna-Rama, Sonia Torres-Sánchez, Karina S MacDowell, José A García-Partida, Cristina Santa-Marta, Esther Berrocoso, Juan C Leza, Manuel Desco, María Luisa Soto-Montenegro
Transl Psychiatry 2024 Jan 8;14(1):14
10.1038/s41398-023-02652-7 38191622

Decreased oxytocin levels related to social cognition impairment in borderline personality disorder
Galvez-Merlin A, López-Villatoro JM, de la Higuera-González P, de la Torre-Luque A, McDowell K, Díaz-Marsá M, Leza JC, Carrasco JL
Acta Psychiatr Scand. 2024 Jun;149(6):458-466
10.1111/acps.13679 38477064

Bacterial lipopolysaccharide forms aggregates with apolipoproteins in male and female rat brains after ethanol binges
Leticia López-Valencia , Marta Moya , Berta Escudero, Borja García-Bueno, Laura Orio
Journal of Lipid Research 2024. Jan 29:100509
10.1016/j.jlr.2024.100509 38295984

Actualización sobre la fisiopatología inflamatoria de la enfermedad mental.
Leza JC
An RANM, Sept. 2024
10.32440/ar.2024.141.02.rev04

Inflammatory profiles in women with eating disorder: Linking inflammatory biomarkers to clinical phenotypes
Marina Díaz-Marsá, Wala Ayad-Ahmed, José Manuel López-Villatoro, Verónica Fernández-Rodrigues, Francisco Ruiz-Guerrero, Andrés Gómez Del Barrio, Luis Beato-Fernández, Filomena Polo-Montes, Magdalena León-Velasco, Alejandro de la Torre-Luque, José Luis Carrasco, Javier R Caso, Karina S MacDowell, Juan C Leza
Psychoneuroendocrinology 2024 Apr:162:106956
10.1016/j.psyneuen.2023.106956. 38218002

THC improves behavioural schizophrenia-like deficits that CBD fails to overcome: a comprehensive multilevel approach using the Poly I:C maternal immune activation
Nicolás Lamanna-Rama, Diego Romero-Miguel, Marta Casquero-Veiga, Karina S MacDowell, Cristina Santa-Marta, Sonia Torres-Sánchez, Esther Berrocoso, Juan C Leza, Manuel Desco, María Luisa Soto-Montenegro
Psychiatry Res. 2024 Jan:331:115643
10.1016/j.psychres.2023.115643 38064909

Microglial morphological/inflammatoryphenotypes and endocannabinoid signalingin a preclinical model of periodontitisand depression
Robledo-Montaña J, Díaz-García C, Martínez M, Ambrosio N, Montero E, Marín MJ, Virto L, Muñoz-López M, Herrera D, Sanz M, Leza JC, García-Bueno B, Figuero E, Martín-Hernández D
J Neuroinflammation. 2024 Sep 8;21(1):219
10.1186/s12974-024-03213-5 39245706

Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes
Stefanie Malan-Müller, Rebeca Vidal, Esther O’Shea, Eduardo Montero, Elena Figuero, Iñaki Zorrilla, Javier de Diego-Adeliño, Marta Cano, Maria Paz García-Portilla, Ana González-Pinto, and Juan C. Leza
Transl Psychiatry. 2024 Sep 24
10.1038/s41398-024-03122-4 39368974

The therapeutic use of clonal neural stem cells in experimental Parkinson's disease
A.Nelke, S. García-López, JR. Caso, MP. Pereira
Stem Cell Research & Therapy, 2024; 15:356
10.1186/s13287-024-03965-0 39385216

Comparison of Micro-CT and Morphometric Outcomes in a Modified Experimental Rat Model of Periodontitis
Jaime Bueno, María Martínez, Nagore Ambrosio, Juan Del Rosal, Javier Robledo-Montaña, Juan D Gamonal, Leire Virto, Eduardo Montero, David Martín-Hernández, María José Marín, David Herrera, Mariano Sanz, Borja García-Bueno, Juan C Leza, Håvard J Haugen, Elena Figuero.
J Periodontal Res. 2024; Oct 22
10.1111/jre.13354 39436969

Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions
Fares-Otero NE; Verdolini N; Melero H; Andrés-Camazón P; Vilajosana E; Cavone V; García-Bueno B; Rapado-Castro M; Izquierdo A; Martín-Hernández D; Mola-Cárdenes P; Leal I; Dompablo M; Ortíz-Tallo A; Martínez-Gras I; Muñoz-Sanjose A; Loeck de Lapuerta C; Rodríguez-Jiménez R; Díaz-Marsá M; Bravo-Ortiz MF; Ibáñez A; Baca-García E; Vieta E; Ayuso-Mateos JL; Malpica-González N; Arango C; Díaz-Caneja CM; Radua J.
Psychol Med 2024 Dec 16:1-14
10.1017/S0033291724002393 39679545

Intestinal permeability biomarkers in patients with schizophrenia: additional support for the impact of lifestyle habits
González-Blanco L; Dal Santo F; García-Portilla MP; Alfonso M; Hernández C; Sánchez-Autet M; Anmella G; Amoretti S; Sanfont G; Martín-Hernández D; Malan-Müller S; Bernardo M; Arranz B
Eur Psychiatry. 2024 Dec 16;67(1):e84
10.1192/j.eurpsy.2024.1765 39676547

The saNeuroGut Initiative: Investigating the Gut Microbiome and Symptoms of Anxiety, Depression, and Posttraumatic Stress
O’Harea M, PP Swart, Malan-Müller S, Van den Heuvel LL, Bröcker E, Seedat S, Hemmings SMJ
Neuroimmunomodulation. 2024; Dec
10.1159/000542696 39561720

Neighborhood Vulnerability and Disability in First Episode of Psychosis: A Multilevel Study
Ana Izquierdo, María Cabello, Itziar Leal, Iosune Torio, José L M Madrigal, Karina S MacDowell, Roberto Rodriguez-Jimenez, David Rentero, Ángela Ibáñez, Miriam Ayora, Covadonga M Díaz-Caneja, Renzo Abregú-Crespo, Blanca Mellor-Marsá, Marina Díaz-Marsá, Norberto Malpica, María-Fé Bravo-Ortiz, Enrique Baca-García, Celso Arango, Jose Luis Ayuso-Mateos; AGES-CM Group
J Clin Psychiatry 2023 Mar 13;84(2):22m14401
10.4088/JCP.22m14401 36920290

Salivary secretory immunoglobulin A as a potential biomarker of psychosocial stress response during the first stages of life: A systematic review.
Castro-Quintas Á, Palma-Gudiel H, San Martín-González N, Caso JR, Leza JC, Fañanás L.
Front Neuroendocrinol 2023 71:101083
10.1016/j.yfrne.2023.101083. 37479062

Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1I249/M280-expressing retina
Church KA, Rodriguez D, Mendiola AS, Vanegas D, Gutierrez IL, Tamayo I, Amadu A, Velazquez P, Cardona SM, Gyoneva S, Cotleur AC, Ransohoff RM, Kaur T, Cardona AE
Front Immunol 2023 Mar 22;14:1130735
10.3389/fimmu.2023.1130735 37033925

Oxidative stress and inflammatory pathways in female eating disorders and borderline personality disorders with emotional dysregulation as linking factors with impulsivity and trauma
Francisco Ruiz-Guerrero, Andrés Gomez Del Barrio, Alejandro de la Torre-Luque, Wala Ayad-Ahmed, Luis Beato-Fernandez, Filomena Polo Montes, Magdalena Leon Velasco, Karina S MacDowell, Juan C Leza, José Luis Carrasco, Marina Díaz-Marsá
Psychoneuroendocrinology 2023 Sep 6;158:106383
10.1016/j.psyneuen.2023.106383 37714047

Transdiagnostic inflammatory and oxidative biomarkers with predictive capacity of self-injurious behavior in impulsive and unstable disorders
J M López-Villatoro, A De la Torre-Luque, KS MacDowell, A Galvez-Merlin, A Gómez Del Barrio, L Beato-Fernández, F Ruiz-Guerrero, P Mola-Cardenes, F Polo-Montes, M León-Velasco, L Castro-Fuentes, JC Leza, J L Carrasco, M Díaz-Marsá
Prog Neuropsychopharmacol Biol Psychiatry 2023 Dec 25:130:11092710.1016/j.pnpbp.2023.110927 38151169

Inflammatory and oxidative endophenotypes in borderline personality disorder: A biomarker cluster analysis
J M López-Villatoro, M Díaz-Marsá, A De la Torre-Luque, K S MacDowell, C Prittwitz, J C Leza, J L Carrasco
World J Biol Psychiatry 2023 Mar 15;1-8
10.1080/15622975.2023.2183254 36919867

The gut-microbiota-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiota composition linked to anxiety, trauma, and depression profiles
Malan-Müller S, Valles-Colomer M, Palomo T, Leza JC
Gut Microbes 2023 Jan-Dec;15(1):2162306
10.1080/19490976.2022.2162306 36651663

Association of Prolactin, Oxytocin and Homocysteine with the clinical and cognitive features of a First Episode of Psychosis over a 1-year follow-up
María Hidalgo-Figueroa, Alejandro Salazar, Cristina Romero-López-Alberca, Karina S MacDowell, Borja Garcia-Bueno, Miquel Bioque, Miquel Bernardo, Mara Parellada, Ana Gonzalez-Pinto, M Paz Garcia-Portilla, Antonio Lobo, Roberto Rodriguez-Jiménez, Esther Berrocoso, Juan C Leza; From the FLAMM-PEPs study CIBERSAM
Int J Neuropsychopharmacol 2023 Aug 21;pyad051
10.1093/ijnp/pyad051 37603404

Editorial: Neuroinflammatory and oxidative/nitrosative pathways in neuropsychiatric and neurological diseases and their possible neuropharmacological regulation, Volume II
Marta P Pereira, Borja García-Bueno, Javier R Caso
Front Pharmacol 2023 mar 180:19:07
10.3389/fphar.2023.1191907 37063292

Neuroinflammation related to the blood-brain barrier and sphingosine-1-phosphate in a pre-clinical model of periodontal diseases and depression in rats
Martín-Hernández D, Martínez M, Robledo-Montaña J, Muñoz-López M, Virto L, Ambrosio N, Marín MJ, Montero E, Herrera D, Sanz M, Leza JC, Figuero E, García-Bueno B
J Clin Periodontol 2023 Jan 16
10.1111/jcpe.13780 36644813

Immune System and Brain/Intestinal Barrier Functions in Psychiatric Diseases: Is Sphingosine-1-Phosphate at the Helm?
Martín-Hernández D, Muñoz-López M, Tendilla-Beltrán H, Caso JR, García-Bueno B, Menchén L, Leza JC
Int J Mol Sci. 2023 Aug 10;24(16):12634
10.3390/ijms241612634 37628815

A Network Analysis Investigating the Associations between Posttraumatic Stress Symptoms, Markers of Inflammation and Metabolic Syndrome
Moodley, A., Womersley, J. S., Swart, P. C., van den Heuvel, L. L., Malan-Müller, S., Seedat, S., Hemmings, S. M. J.
J Psychiatr Res 2023 Sep:165:105-114
doi: 10.1016/j.jpsychires.2023.07.018 37487292

Neuroimaging revealed long-lasting glucose metabolism changes to morphine withdrawal in rats pretreated with the cannabinoid agonist CP-55,940 during periadolescence
N Lamanna-Rama, K S MacDowell, G López, J C Leza, M Desco, E Ambrosio, M L Soto-Montenegro
Eur Neuropsychopharmacol 2023 Apr;69:60-76
10.1016/j.euroneuro.2023.01.005 36780817

Platelets Bridging the Gap between Gut Dysbiosis and Neuroinflammation in
Stress-Linked Disorders: A Narrative Review
Rust, C., Malan-Muller, S.,van den Heuvel, L. L., et al
J Neuroimmunol. 2023 Sep 15:382:578155.
doi: 10.1016/j.jneuroim.2023.578155 doi: 10.1016/j.jneuroim.2023.57815537523892

Editorial: Non-canonical Pathways of Psychiatric Drugs: Beyond Their Neurotransmitter Action T
endilla-Beltrán H, Martín-Hernández D
Front Neurosci. 2023 Sep 1:17:1278748

The relationship between negative symptoms, social cognition, and social functioning in patients with first episode psychosis
García-López M, Alonso-Sánchez M, Leal I, Martín-Hernández D, Caso JR, Díaz-Caneja CM, Andreu-Bernabeu Á, Arango C, Rodriguez-Jimenez R, Sánchez-Pastor L, Díaz-Marsá M, Mellor-Marsá B, Ibáñez Á, Malpica N, Bravo-Ortiz MF, Baca-Garcia E, Ayuso-Mateos JL, Izquierdo A; Grupo AGES-CM
J Psychiatr Res. 2022 Nov;155:171-179
10.1016/j.jpsychires.2022.08.004 36041260

The effects of mango leaf extract during adolescence and adulthood in a rat model of schizophrenia
Garcia-Partida JA, Torres-Sanchez S, MacDowell K, Fernández-Ponce MT, Casas L, Mantell C, Soto-Montenegro ML, Romero-Miguel D, Lamanna-Rama N, Leza JC, Desco M, Berrocoso E
Front Pharmacol 2022 Jul 26;13:886514
10.3389/fphar.2022.886514 35959428

Immune-Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study
Garés-Caballer M, Sánchez-Ortí JV, Correa-Ghisays P, Balanzá-Martínez V, Selva-Vera G, Vila-Francés J, Magdalena-Benedito R, San-Martin C, Victor VM, Escribano-Lopez I, Hernandez-Mijares A, Vivas-Lalinde J, Vieta E, Leza JC, Tabarés-Seisdedos R
Front Neurol 2022 Jun 2;13:883927
10.3389/fneur.2022.883927 35720107

Examining the immune signatures of SARS-CoV-2 infection in pregnancy and the impact on neurodevelopment: Protocol of the SIGNATURE longitudinal study
Garrido-Torres N, Cerrillos L, García Cerro S, Pérez Gómez A, Canal-Rivero M, de Felipe B, Alameda L, Marqués Rodríguez R, Anillo S, Praena J, Duque Sánchez C, Roca C, Paniagua M, López Díaz A, Romero-García R, Olbrich P, Puertas Albarracín MP, Reguera Pozuelo P, Sosa IL, Moreno Dueñas MB, Pineda Cachero R, Zamudio Juan L, García Rumi V, Guerrero Benitez M, Figueroa R, Martín Rendón AM, Partida A, Rodríguez Cocho MI, Gallardo Trujillo C, Gallego Jiménez I, García Spencer S, Gómez Verdugo M, Bermejo Fernández C, Pérez Benito M, Castillo Reina RE, Cejudo López A, Sánchez Tomás C, Chacón Gamero MÁ, Rubio A, Moreno Mellado A, Ramos Herrero V, Starr E, González Fernández de Palacios M, García Victori E, Pavón Delgado A, Fernández Cuervo I, Arias Ruiz A, Menéndez Gil IE, Domínguez Gómez I, Coca Mendoza I, Ayesa-Arriola R, Fañanas L, Leza JC, Cisneros JM, Sánchez Céspedes J, Ruiz-Mateos E, Crespo-Facorro B, Ruiz-Veguilla M
Front Pediatr 2022 Dec 21;10:899445
10.3389/fped.2022.899445 36619503

Noradrenaline in Alzheimer's Disease: A New Potential Therapeutic Target
Gutiérrez IL, Dello Russo C, Novellino F, Caso JR, García-Bueno B, Leza JC, Madrigal JLM
Int J Mol Sci 2022 May 30;23(11):6143
10.3390/ijms23116143 35682822

CCL2 Inhibition of Pro-Resolving Mediators Potentiates Neuroinflammation in Astrocytes
Gutiérrez IL, Novellino F, Caso JR, García-Bueno B, Leza JC, Madrigal JLM
Int J Mol Sci 2022 Mar 18;23(6):3307
10.3390/ijms23063307 35328727

The Influence of Oxytocin and Prolactin During a First Episode of Psychosis: The Implication of Sex Differences, Clinical Features, and Cognitive Performance
Hidalgo-Figueroa M, Salazar A, Romero-López-Alberca C, MacDowell KS, García-Bueno B, Bioque M, Bernardo M, Parellada M, González-Pinto A, García Portilla MP, Lobo A, Rodriguez-Jimenez R, Berrocoso E, Leza JC; FLAMM-PEPs study; CIBERSAM
Int J Neuropsychopharmacol. 2022 Aug 16;25(8):666-677
10.1093/ijnp/pyac023 35353882

Reduced glucocorticoid receptor expression in blood mononuclear cells of patients with borderline personality disorder
López-Villatoro JM, MacDowell KS, Diaz-Marsá M, De La Torre-Luque A, Prittwitz C, Galvez-Merlin A, Leza JC, Carrasco JL
Front Psychiatry. 2022 Aug 2;13:951373
10.3389/fpsyt.2022.951373 35982938

Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress
Martín-Hernández D, Gutiérrez IL, González-Prieto M, MacDowell KS, Robledo-Montaña J, Tendilla-Beltrán H, Calleja-Rodríguez N, Bris ÁG, Ulecia-Morón C, Moreno B, Caso JR, García-Bueno B, Rodrigues-Mascarenhas S, Marín-Jiménez I, Leza JC, Menchén L
Sci Rep. 2022 Mar 8;12(1):4073
10.1038/s41598-022-08011-8 35260749

The Role of the Oral Microbiota Related to Periodontal Diseases in Anxiety, Mood and Trauma- and Stress-Related Disorders
Martínez M, Postolache TT, García-Bueno B, Leza JC, Figuero E, Lowry CA, Malan-Müller S
Front Psychiatry. 2022 Jan 27;12:814177
10.3389/fpsyt.2021.814177 35153869

The role of BDNF and NGF plasma levels in first-episode schizophrenia: A longitudinal study
Martínez-Pinteño A, Mezquida G, Bioque M, López-Ilundain JM, Andreu-Bernabeu Á, Zorrilla I, Mané A, Rodríguez-Jiménez R, Corripio I, Sarró S, Ibáñez Á, Usall J, Rivero O, Gassó P, Leza JC, Cuesta MJ, Parellada M, González-Pinto A, Berrocoso E, Mas S, Bernardo M; 2EPs Group
Eur Neuropsychopharmacol- 2022 Apr;57:105-117
10.1016/j.euroneuro.2022.02.003 35219096

Disinhibition-Like Behavior Correlates with Frontal Cortex Damage in an Animal Model of Chronic Alcohol Consumption and Thiamine Deficiency
Moya M, López-Valencia L, García-Bueno B, Orio L
Biomedicines 2022 Jan 25;10(2):260
10.3390/biomedicines10020260 35203470

Cognitive functioning in essential tremor without dementia: a clinical and imaging study
Novellino F, Saccà V, Salsone M, Nicoletti G, Quattrone A, Chiriaco C, Madrigal JLM, Quattrone A
Neurol Sc I 2022 Aug;43(8):4811-4820
10.1007/s10072-022-06045-4 35511382

Connectivity Alterations in Vascular Parkinsonism: A Structural Covariance Study
Novellino, F, Salsone, M, Riccelli, R, Chiriaco, C, Argiro, G, Quattrone, A, Madrigal, JLM, Strambi, LF, Quattrone, A
Appl. Sci.-Basel 2022 12(14), 7240
10.3390/app12147240

Editorial: Neuroinflammatory and oxidative/nitrosative pathways in neuropsychiatric and neurological diseases and their possible neuropharmacological regulation, volume I
Pereira MP, García-Bueno B, Caso JR
Front Pharmacol 2022 Sep 16;13:1033281
10.3389/fphar.2022.1033281 36188591

Challenging functional connectivity data: machine learning application on essential tremor recognition
Saccà V, Novellino F, Salsone M, Abou Jaoude M, Quattrone A, Chiriaco C, Madrigal JLM, Quattrone A
Neurol Sci 2022 Sep
20 10.1007/s10072-022-06400-5 36123559

Lipid nanoparticles for antisense oligonucleotide gene interference into brain border-associated macrophages
Calero M, Moleiro LH, Sayd A, Dorca Y, Miquel-Rio L, Paz V, Robledo-Montaña J, Enciso E, Acción F, Herráez-Aguilar D, Hellweg T, Sánchez L, Bortolozzi A, Leza JC, García-Bueno B, Monroy F
Front Mol Biosci 2022 Nov 3;9:887678
10.3389/fmolb.2022.887678 36406277

Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders
Caso JR, MacDowell KS, Soto M, Ruiz-Guerrero F, Carrasco-Díaz Á, Leza JC, Carrasco JL, Díaz-Marsá M
Front Pharmacol 2022 Apr 19;13:846172
10.3389/fphar.2022.846172 35517819

Preclinical animal models of mental illnesses to translate findings from the bench to the bedside: Molecular brain mechanisms and peripheral biomarkers associated to early life stress or immune challenges
Cattane N, Vernon AC, Borsini A, Scassellati C, Endres D, Capuron L, Tamouza R, Benros ME, Leza JC, Pariante CM, Riva MA, Cattaneo A; European College of Neuropsychopharmacology (ECNP) ImmunoNeuroPsychiatry Thematic Working Group
Eur Neuropsychopharmacol. 2022 May;58:55-79
10.1016/j.euroneuro.2022.02.002 35235897

Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina
Church KA, Rodriguez D, Vanegas D, Gutierrez IL, Cardona SM, Madrigal JLM, Kaur T, Cardona AE
J Neuroinflammation. 2022 Dec 14;19(1):300
10.1186/s12974-022-02659-9 36517889

Inflammation biomarkers in suicide attempts and their relation to abuse, global functioning and cognition
Fernández-Sevillano J, González-Ortega I, MacDowell K, Zorrilla I, López MP, Courtet P, Gabilondo A, Martínez-Cengotitabengoa M, Leza JC, Sáiz P, González-Pinto A
World J Biol Psychiatry. 2022 Mar-Apr;23(4):307-317
10.1080/15622975.2021.1988703 34730074

Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder
Caso JR, MacDowell KS, González-Pinto A, García S, de Diego-Adeliño J, Carceller-Sindreu M, Sarramea F, Caballero-Villarraso J, Gracia-García P, De la Cámara C, Agüera L, Gómez-Lus ML, Alba C, Rodríguez JM, Leza JC
Transl Psychiatry 2021 Dec 21;11(1):645
10.1038/s41398-021-01755-3 34934041

Omega-3 fatty acids during adolescence prevent schizophrenia-related behavioural deficits: Neurophysiological evidences from the prenatal viral infection with PolyI:C
Casquero-Veiga M, Romero-Miguel D, MacDowell KS, Torres-Sánchez S, García- Partida JA, Lamanna-Rama N, Gómez-Rangel V, Romero-Miranda A, Berrocoso E, Leza JC, Arango C, Desco M, Soto-Montenegro ML
Eur Neuropsychopharmacol 2021 May;46:14-27
10.1016/j.euroneuro.2021.02.001 33735708

Severe mental illness and European COVID-19 vaccination strategies
De Picker LJ, Dias MC, Benros ME, Vai B, Branchi I, Benedetti F, Borsini A, Leza JC, Kärkkäinen H, Männikkö M, Pariante CM, Güngör ES, Szczegielniak A, Tamouza R, van der Markt A, Fusar-Poli P, Beezhold J, Leboyer M
Lancet Psychiatry 2021 May;8(5):356-359
10.1016/S2215-0366(21)00046-8 33609450

Viewpoint | European COVID-19 exit strategy for people with severe mental disorders: Too little, but not yet too late
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Brain Behav Immun 2021 May;94:15-17
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Inflammatory dysregulation in women with an eating disorder: Relationships with altered emotional reactivity Díaz-Marsa M, MacDowell K, de laTorre-Luque A, Caso JR, Faya M, Gutiérrez S, Soto M, Pemau A, Díaz-Carracedo P, Carrasco-Díaz A, Leza JC, Graell M, Carrasco JL
Int J Eat Disord. 2021 Oct;54(10):1843-1854
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Cannabidiol antidepressant-like effect in the lipopolysaccharide model in mice: Modulation of inflammatory pathways
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Biochem Pharmacol 2021 Mar;185:114433
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Microglial CX3CR1 production increases in Alzheimer's disease and is regulated by noradrenaline
González-Prieto M, Gutiérrez IL, García-Bueno B, Caso JR, Leza JC, Ortega-Hernández A, Gómez-Garre D, Madrigal JLM
Glia 2021 Jan;69(1):73-90
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How does neighbourhood socio-economic status affect the interrelationships between functioning dimensions in first episode of psychosis? A network analysis approach
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The interplay between functioning problems and symptoms in first episode of psychosis: An approach from network analysis
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J Psychiatr Res. 2021 Apr;136:265-273
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Paliperidone attenuates chronic stress-induced changes in the expression of inflammasomes-related protein in the frontal cortex of male rats
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Int Immunopharmacol. 2021 Jan;90:107217
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Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways
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Front Pharmacol. 2021 May 13;12:682602
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Periodontal diseases and depression: A pre-clinical in vivo study
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J Clin Periodontol. 2021 Apr;48(4):503-527
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Liver X Receptor Exerts Anti-Inflammatory Effects in Colonic Epithelial Cells via ABCA1 and Its Expression Is Decreased in Human and Experimental Inflammatory Bowel Disease
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Inflamm Bowel Dis 2021 Oct 18;27(10):1661-1673
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Cerebellar and cortical TLR4 activation and behavioral impairments in Wernicke-Korsakoff Syndrome: Pharmacological effects of oleoylethanolamide
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Prog Neuropsychopharmacol Biol Psychiatry 2021 Jun 8;108:110190
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Complete blood cell count-derived ratios can be useful biomarkers for neurological diseases
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Childhood trauma determines different clinical and biological manifestations in patients with eating disorders
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Eat Weight Disord 2021 Apr;26(3):847-857
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A Characterization of the Effects of Minocycline Treatment During Adolescence on Structural, Metabolic, and Oxidative Stress Parameters in a Maternal Immune Stimulation Model of Neurodevelopmental Brain Disorders
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Int J Neuropsychopharmacol. 2021 Sep 21;24(9):734-748
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Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia- related developmental model in rats
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The prefrontal cortex as a target for atypical antipsychotics in schizophrenia, lessons of neurodevelopmental animal models
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Prog Neurobiol. 2021 Apr;199:101967
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Analysis of Molecular Networks in the Cerebellum in Chronic Schizophrenia: Modulation by Early Postnatal Life Stressors in Murine Models
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Int J Mol Sci 2021 Sep 17;22(18):10076
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Kynurenine pathway in post-mortem prefrontal cortex and cerebellum in schizophrenia: relationship with monoamines and symptomatology
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J Neuroinflammation. 2021 Sep 12;18(1):198
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COVID-19 as a unique opportunity to unravel the link between prenatal maternal infection, brain development and neuropsychiatric disorders in offspring
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Acute effects of a session of electroconvulsive therapy on brain-derived neurotrophic factor plasma levels
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Rev Psiquiatr Salud Ment (Engl Ed) 2020 Jul 13;S1888-9891(20)30069-0
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Decreased oxytocin plasma levels and oxytocin receptor expression in borderline personality disorder
Carrasco JL, Buenache E, MacDowell KS, De la Vega I, López-Villatoro JM, Moreno B, Díaz-Marsá M, Leza JC
Acta Psychiatr Scand. 2020 Oct;142(4):319-325
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Dysfunction of inflammatory pathways in adolescent female patients with anorexia nervosa
Caso JR, Graell M, Navalón A, MacDowell KS, Gutiérrez S, Soto M, Leza JC, Carrasco JL, Marsá MD
Prog Neuropsychopharmacol Biol Psychiatry 2020 Jan 10;96:109727
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Functionality and Neurocognition in Patients With Bipolar Disorder After a Physical-Exercise Program (FINEXT-BD Study): Protocol of a Randomized Interventionist Program.
García S, Gorostegi-Anduaga I, García-Corres E, Maldonado-Martín S, MacDowell KS, Bermúdez-Ampudia C, Apodaca MJ, Pérez-Landaluce I, Tobalina-Larrea I, Leza JC, González-Pinto A.
Front Psychiatry 2020 Oct 29;11:568455
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Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study
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Inflammatory and antioxidant pathway dysfunction in borderline personality disorder
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Psychiatry Res. 2020 Feb;284:112782
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Depletion of brain perivascular macrophages regulates acute restraint stress-induced neuroinflammation and oxidative/nitrosative stress in rat frontal cortex
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Eur Neuropsychopharmacol. 2020 May;34:50-64
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Toll-like receptor 4 agonist and antagonist lipopolysaccharides modify innate immune response in rat brain circumventricular organs
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J Neuroinflammation 2020 Jan 6;17(1):6
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Effects of electroconvulsive therapy in the systemic inflammatory balance of patients with severe mental disorder
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Psychiatry Clin Neurosci. 2019 Oct;73(10):628-635
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Risperidone administered during adolescence induced metabolic, anatomical and inflammatory/oxidative changes in adult brain: A PET and MRI study in the maternal immune stimulation animal model
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Eur Neuropsychopharmacol. 2019 Jul;29(7):880-896
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Oxidative Stress and Inflammation in First- Episode Psychosis: A Systematic Review and Meta-analysis
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Schizophr Bull. 2019 Jun 18;45(4):742-751
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Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania
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Front Psychiatry. 2019 Mar 26;10:162
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Early versus late stage schizophrenia. What markers make the difference?García-Álvarez L, García-Portilla MP, Caso JR, de la Fuente-Tomás L, González-Blanco L, Sáiz Martínez P, Leza JC, Bobes J
World J Biol Psychiatry. 2019 Feb;20(2):159-165
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Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice
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Reboxetine Treatment Reduces Neuroinflammation and Neurodegeneration in the 5xFAD Mouse Model of Alzheimer's Disease: Role of CCL2
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Mol Neurobiol. 2019 Dec;56(12):8628-8642
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Modulation of Monoaminergic Systems by Antidepressants in the Frontal Cortex of Rats After Chronic Mild Stress Exposure
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Mol Neurobiol. 2019 Nov;56(11):7522-7533
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Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats
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Mol Neurobiol. 2019 Jan;56(1):490-501
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Differences in the regulation of inflammatory pathways in adolescent- and adult-onset first-episode psychosis
Moreno C, Parellada M, MacDowell KS, García-Bueno B, Cabrera B, González- Pinto A, Saiz P, Lobo A, Rodriguez-Jimenez R, Berrocoso E, Bernardo M, Leza JC; From the FLAMM-PEPs study, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
Eur Child Adolesc Psychiatry 2019 Oct;28(10):1395-1405
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Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse Orio L, Alen F, Pavón FJ, Serrano A, García-Bueno B
Front Mol Neurosci 2019 Jan 9;11:490
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Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients
Oriolo G, Blanco-Hinojo L, Navines R, Mariño Z, Martín-Hernández D, Cavero M, Gimenez D, Caso J, Capuron L, Forns X, Pujol J, Sola R, Martin-Santos R
Brain Behav Immun 2019 Aug;80:204-218
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CIBERSAM: Ten years of collaborative translational research in mental disorders
Salagre E, Arango C, Artigas F, Ayuso-Mateos JL, Bernardo M, Castro- Fornieles J, Bobes J, Desco M, Fañanás L, González-Pinto A, Haro JM, Leza JC, Mckenna PJ, Meana JJ, Menchón JM, Micó JA, Palomo T, Pazos Á, Pérez V, Saiz-Ruiz J, Sanjuán J, Tabarés-Seisdedos R, Crespo-Facorro B, Casas M, Vilella E, Palao D, Olivares JM, Rodriguez-Jimenez R, Vieta E
Rev Psiquiatr Salud Ment (Engl Ed) 2019 Jan-Mar;12(1):1-8
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Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion
Tendilla-Beltrán H, Meneses-Prado S, Vázquez-Roque RA, Tapia-Rodríguez M, Vázquez-Hernández AJ, Coatl-Cuaya H, Martín-Hernández D, MacDowell KS, Garcés-Ramírez L, Leza JC, Flores G.
J Neurosci 2019 Oct 23;39(43):8584-8599
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