Departamentos

Publicaciones

-NIHR Global Health Research Unit on Global SurgerySTARSurg Collaborative [Begoña Quintana-Villamandos, local collaborator]. A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts. Lancet Digit Health 2024 Jul;6(7):e507-e519.

-Arnalich-Montiel A, Burgos-Santamaria A, Pazó-Sayós L, Quintana-Villamandos B. Comprehensive management of stroke: from mechanisms to therapeutic approaches. Int J Mol Sci 2024;25: 5252

- Ruiz Fernández M, Quintana-Villamandos B, Rodríguez Abellá H, Cuerpo caballero GC, Pedraz Prieto A, Monzón Díaz D, Murgoitio Esandi U, Villa Gallardo Y, García Meré C, González Pinto A, Del Cañizo López JF. Estimación de la perfusión  de hígado e íleon terminal con microesferas coloreadas, comparando asistencias mecánicas circulatorias de flujo contínuo y pulsátil. Cirugía Cardiovascular 2024;31(3):94-102

- Monedero Cobeta I, Gomez Bris R, Rodríguez-Rodríguez P, Saez A, Quintana-Villamandos B, González Granado JM, Arribas SM. Fetal programmng and lactation: Modulating gene expression in response to undernutrition during intrauterine life. Pedriatric Research, 2024 doi: 10.1038/s41390-024-03042-5.

- Pérez-Granda MJ, Barrio JM, Cuerpo G, Valerio M, Muñoz P, Hortal J, Pinto AG, Bouza E; Cardiovascular Infection Study Group (Begoña Quintana)Infectious complications following major heart surgery from the day of the surgery to hospital discharge. BMC Infect Dis. 2024 Jan 11;24(1):73. doi: 10.1186/s12879-023-08972-9.

- NIHR Global Health Unit on Global Surgery [Begoña Quintana-Villamandos, local collaborator]. Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries. BJS 2023;110(7):804-817

-NIHR Global Health Unit on Global Surgery, COVIDSurg Collaborative [Begoña Quintana-Villamandos, local collaborator]. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. Lancet. 2022;400(10363):1607-17. doi: 10.1016/S0140-6736(22)01846-3.

-Martín-Oropesa R, Rodríguez-Rodríguez P, Pazó-Sayós L, Arnalich-Montiel A, Arribas SM, González MC, Quintana-Villamandos BMaintenance over time of the effect produced by esmolol on the structure and function of coronary arteries in hypertensive heart diseases. Antioxidants 2022; 11(10): 2042. doi: 10.3390/antiox11102042 

-Rodríguez-Rodríguez P, Monedero-Cobeta I, Ramiro-Cortijo D, Puthong S, Quintana-Villamandos B, Gil-Ramírez A, Cañas S, Ruvira S,  Arribas SM. Slower growth during lactation rescues early cardiovascular and adipose tissue hypertrophy induced by fetal undernutrition in rats. Biomedicines 2022;10:2504. doi: 10.3390/biomedicines10102504

-Quintana-Villamandos B, Barranco M, Fernández I, Ruiz M, Del Cañizo JF. Cardiac output monitoring with pulmonary versus transcardiopulmonary thermodilution in left ventricular assist devices: interchangeable methods? Front Physiol 2022. DOI 10.3389/fphys.2022.889190

-Olivencia MA, Esquivel-Ruiz S, Callejo M, Mondejar-Parreño G, Quintana-Villamandos B,  Barreira B, Sacedón R, Cogolludo A, Perros F, Mendes-Ferreira P, Pérez Vizcaíno F. Cardiac and pulmonary vascular dysfunction in Vitamin D-deficient Bmpr2-mutant rats. Am J Resp Cell Mol Biol. 2022. doi: 10.1165/rcmb.2022-0001LE.

-COVIDSurg Collaborative. Impact of bacillus Calmette-Guérin (BCG) caccination on postoperative mortality in patients with perioperative SARS_CoV-2 infection. BJS Open 2022;5(6):zrab131. doi: 10.1093/bjsopen/zrab131

- Hitchman L, Machin M, COVIDSurg Collaborative and Vascular and Endovascular Research Network. Impact of COVID-19 on vascular patients worldwide: analysis of the COVIDSurg data. J Cardiovasc Surg 2021;62:558-70.

- Cardiothoracic Interdisciplinary Research Network and COVIDSurg Collaborative. Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohost study. J Thorac Cardiovasc Surg 2021;162:e355-72.

-COVIDSurg Collaborative. SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study. Anaesthesia 2021. doi:10.1111/anae.15563.

-COVIDSurg Collaborative. Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study. Anaesthesia 2021. doi:10.1111/anae.15560.

-Zarragoikoetxea I, Pajares A, Moreno I, Porta J, Koller T, Cegarra V, Gonzalez AI, Eiras M, Sandoval E, Aurelio Sarralde J, Quintana-Villamandos B, Vicente Guillén R. SEDAR/SECCE ECMO management consensus document. Rev Esp Anestesiol Reanim. 2021 Jul 7:S0034-9356(21)00055-4. doi: 10.1016/j.redar.2020.12.011.

-COVIDSurg Collaborative. Machine learning risk preduction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score. Br J Surg. 2021. doi: 10.1093/bjs/znab183.

-Rodríguez-Rodríguez P, Vieira-Rocha MS, Quintana-Villamandos B, Monedero-Cobeta I, Prachaney P, López de Pablo AL, González MC, Morato M, Diniz C, Arribas SM. Implication of RAS in Postnatal Cardiac Remodeling, Fibrosis and Dysfunction Induced by Fetal Undernutrition. Pathophysiol 2021;28:273-290.

-COVIDSurg Collaborative, GlobalSurg Collaborative. SARS-CoV vaccination modelling for safe surgery to save lives: data from an international prospective cohort study. Br J Surg. 2021. doi: 10.1093/bjs/znab101.

-COVIDSurg Collaborative; GlobalSurg Collaborative.  Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study . Anaesthesia 2021. doi: 10.1111/anae.15458.

-Quintana-Villamandos B, Barranco M, Fernández I, Ruiz M, Del Cañizo JF. New Advances in Monitoring Cardiac Output in Circulatory Mechanical Assistance Devices. A Validation Study in a Porcine Model. Front Physiol 2021;12:634779. doi: 10.3389/fphys.2021.634779.

-Nepogodiev D, Covidsurg Collaborators. Favourable perioperative outcomes for children with SARS-CoV-2. Br J Surg 2020;107:e644-e645.

- Pazó-Sayós L, González MC, Quintana-Villamandos B. Inhibition of the NFATc4/ERK/AKT Pathway and Improvement of Thiol-Specific Oxidative Stress by Dronedarone Possibly Secondary to the Reduction of Blood Pressure in an Animal Model of Ventricular Hypertrophy. Front Physiol 2020. doi: 10.3389/fphys.2020.00967.

-Quintana-Villamandos B, Pazó-Sayós L, González del Pozo I, Rodríguez-Rodríguez P, Bellón JM, Pedraz-Prieto A, Pinto A, González MC. OXY-SCORE: a new perspective for left ventricular hypertrophy diagnosis. Ther Adv Chronic Dis 2020;11:1-10.

-COVIDSurg Collaborative. Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study. The Lancet 2020:S0140-6736(20)31182-X. doi: 10.1016/S0140-6736(20)31182-X

-Benito-Sanz P, Garrido A, Quintana-Villamandos B, Barrio JM, Fernández-Quero L, Hosrtal J. Perforation of the left ventricle wall due to the insertion of a pulmonary artery catheter. A case report. Rev Esp Anesthesiol Reanim 2019.; 66 (10):528-532.

- Quintana-Villamandos B, Delgado-Martos MJ, Delgado-Baeza MJ. Early reversal cardiac with esmolol in hypertensive rats: the role of subcellular organelle phenotype. Pharmacol Rep 2019;71:1125-1132.

- Quintana-Villamandos B, Delgado-Martos MJ, Delgado-Baeza E. Impact of a multichanel blocker in attenuating intramyocardial artery remodeling in hypertensive rats through increased nitric oxide bioavailability. Biomed Int Res 2019; 2019:6374582.

- Quintana-Villamandos B, González MC, Delgado-Martos MJ,  Gutiérrez-Arzapalo PY, Böger RH, Lüneburg N, Muñoz D, Delgado-Baeza E. The protective effect of dronedarone on the structure and mechanical properties of the aorta in hypertensive rats by decreasing the concentration of symmetric dimethylarginine (SDMA). Plos One 2019; 14(5):e0216820.

- Quintana-Villamandos B, González del Pozo I, Pazó-Sayós L, Bellón JM, Pedraz-Prieto A, González Pinto A, Delgado-Baeza E. Plasma protein yhiolation index (PTI) as a potential biomarker for left ventricular hypertrophy in humans. Plos One 2019;14(5):e0216359.

- Quintana-Villamandos B, Pazó-Sayós L, Arribas SM, Rodríguez-Rodríguez P, Boger RH, Luneburg N, Delgado-Baeza E, González MC. Dronedarone induces regression of coronary artery remodeling related to better global antioxidant status. Hypertens Res 2019. DOI: 10.1038/s41440-019-0257-z

- Morillas-Sendín P, Del Cañizo JF, Ruiz M, Delgado-Baeza E, Quintana-Villamandos B. Randomized comparison of sevoflurane versus propofol on organ blood flow after partial thoracic aortic ceoss-clamping. Int J Clin Exp Med 2019;12:1226-1233.

- Quintana-Villamandos B, Goukassian DA, Sasi SP, Delgado-Baeza E. Short-term treatment with esmolol reverses left ventricular hypertrophy in adult spontaneously hypertensive rats via inhibition  Akt/NF-kB and NFATc4. Biomed Res Int 2018;;2018:2691014. doi: 10.1155/2018/2691014.

- Quintana-Villamandos B, Gómez de Diego JJ, María Delgado-Martos MJ, Muñoz-Valverde D, Soto-Montenegro ML, Desco M, Delgado-Baeza E. Dronedarone produces early regression of myocardial remodelling in structural heart disease. Plos One 2017;12:e0188442. doi: 10.1371/journal.pone.0188442.

- Vera-Sánchez MB, Quintana-Villamandos B. Medtronic electromyographic traqueal tube. Anaesthesia 2017;72:1282-1283.

- Rodríguez-Rodríguez P, López de Pablo AL, Fernández C, Somoza B, Quintana-Villamandos B, Gómez de Diego JJ, Gutierrez-Arzapalo PY, Ramiro-Cortijo D, Gonzalez MC, Arribas SM. Long term effects of fetal undernutrition on rat heart. Role of hypertension and oxidative stress. Plos One 2017;13:e0171544. doi: 10.1371/journal.pone.0171544.

- Quintana-Villamandos B, Delgado-Martos MJ, Delgado-Baeza E. Adverse remodeling of the obtuse marginal artery in compensatory hypertrophied myocardium from spontaneously hypertensive rats. Cardiovasc Pathol 2017;26:51-54.

- Quintana-Villamandos B, González MC, Delgado-Martos MJ, Condezo-Hoyos L, Boger RH, Luneburg N, Pazó-Sayós L, Yareli Gutiérrez P, Delgado-Baeza E. Short-term esmolol attenuated remodeling of the thoracic aorta in hypertensive rats by decreasing concentrations of ADMA down-regulated by oxidative stress. Eur J pharmacol 2016;791:502-509.

- Quintana-Villamandos B, Arnalich-Montiel A, Arribas S, Lüneburg N, Böger RH, Delgado-Martos MJ, Fernández-Criado C, Delgado-Baeza E, González.Early regression of coronary artery remodeling with esmolol and DDAH/ADMA pathway in hypertensive rats. Hypertens Res 2016:39:692-700.

- Quintana-Villamandos B, Delgado-Baeza E. Does theADMA/DDAH/NO pathway modulate early regression of left ventricular hypertrophy with esmolol. Med Hypotheses 2016; 87:44-47.

- Morillas-Sendín P, Delgado-Baeza E, Delgado-Martos MJ, Barranco M, Del Cañizo JF, Ruíz M, Quintana B. Effect os sevoflurane and propofol on organ blood flow in left ventricular devices in pigs. Biomed Res Int 2015;2015;8988373.

- Rodríguez-Bernal GJ, Sánchez-Hernández JJ,Morillas P, Otero J, Del Cañizo JF, Delgado-Martos MJ, Delgado-Baeza E, Quintana-Villamandos B. Effects of ventricularassist deviceson cerebral blood flow: comparison of pulsatile-flow and continuous –flow devices. Exp Clin Cardiol 2014; 20:1615-1625.

- Arnalich-Montiel A,  González MC, Delgado-Baeza E, Delgado-Martos MJ, Condezo-Hoyos L, Martos-Rodríguez A, Rodríguez-Rodríguez P, Quintana-Villamandos B. Short-term esmolol improves coronary artery remodeling in spontaneously hypertensive rats through increased nitric oxide bioavailability and superoxide dismutase activity. BioMed Res Int 2014;2014;531087.

- Quintana-Villamandos B, Delgado-Baeza E. Is left ventricular hypertrophy early regression pssible? Int J Anesthetic Anesthesiol 2014;1:1.

- Delgado-Martos MJ, Touza-Fernández A, Canillas F, Quintana- Villamandos B, Martos-Rodriguez A, Delgado-Baeza E. Growth Plate Allograft Free Floating in Its Natural Bed with No Attachment to the Bone - Experimental Pilot Study in Rats. Journal of Contemporary Orthopaedic Research  2014;1;1-13.

- Quintana-Villamandos B, Delgado-Martos MJ, Sánchez-Hernández JJ, Gómez de Diego JJ, Fernández MC, Canillas F, Martos- Rodríguez A, Delgado-Baeza E. Early regression of left ventricular hypertrophy after treatment with esmolol in an experimental rat model of primary hypertension. Hypertens Res 2013; 36:408-413.

- Quintana-Villamandos B, Delgado-Martos MJ, Fernández-Riveira MC, Fernández-Criado MC, Martos-Rodríguez A, Canillas F and Delgado-Baeza E. Can 18F-FDG-PET show differences in myocardial metabolism between Whistar Kyoto rats and spontaneously hypertensive rats? Lab Anim 2013;47:320-323.

- Delgado-Martos MJ, Touza Fernández A, Canillas F, Quintana-Villamandos B, Santos Del Riego S, Delgado-Martos E, Martos-Rodriguez A, Delgado-Baeza E. Does the epiphyseal cartilage of the long bones have one or two ossification fronts? Med Hypotheses 2013;81:695-700.

- Canillas F, Delgado-Martos MJ, Martos-Rodríguez A, Quintana-Villamandos B, Delgado-Baeza E. Contribution to the inicial pathodynamics of hip luxation in young rats. J Pediatric Ortophaedic 2012;32:613-620.

- Quintana-Villamandos B, Rodríguez-Bernal GJ, Pérez-Caballero R, Otero J, Ruiz M, Delgado-Martos MJ, Sánchez-Hernández JJ, Delgado-Baeza E, Del Cañizo JF. Severe hypoxaemia with a left ventricular assist device in a minpig model with an undiagnosed congenital cardiac disease. Laboratory Animals 2012;46:77-80.

- Heredero A, Pérez-Caballero R, Otero J, Rodríguez-Martínez D, Quintana-Villamandos B, Rodríguez-Bernal G, González-Pinto A, Ruiz-Fernández M, del Cañizo JF. Synchrony relationships between left ventricular and lef ventricular assist device: An experimental study in pigs. Int J Artif Organs 2012;35:272-278.

- Canillas del Rey F, Delgado-Martos MJ, Muñoz-ValverdeD, Quintana-Villamandos B, Martos-Rodríguez A, Delgado-Baeza E. Hip joint phylogenesis. Phenotypic plasticity. Lamarckian or Darwinian paradigm? Part II. Rev Esp Cir Ortop traumatol 2012;56:245-257.

- Conde MV, González MC, Quintana-Villamandos B, Abderrahim F, Briones AM, Condezo-Hoyos LA, Regadera J, Susin C, Gómez de Diego JJ, Delgado-Baeza E, Díaz-Gil JJ, Arribas SM. Liver growth factor treatment restores cell-extracellular matrix balance in resistence arteries and improves left ventricular hypertrophy in SHR. Am J Physiol Heart Circ Physiol 2011;301:H1153-H1165.

- Cañizo JF, Rodríguez-Martínez D, Pérez-Caballero R, Quintana B, Ruiz M.Low-cost Pulsatile Cardiac Assist Device with Compliant Input Chamber.Artif Organs2010;34:136-140.

- Millán C, Quintana B, Rodríguez A, Iglesias, Barranco M, Navia J. Eficacia del factor VII recombinante activado  en el tratamiento de la  hemorragia masiva en el p Mostoperatorio de cirugía cardiaca: experiencia en 32 pacientes. Rev Esp Anestesiol Reanim 2009; 56: 485-492.

- Quintana Villamandos MB, Sánchez Hernández JJ, Delgado Martos MJ, Delgado Baeza E. Evolutional patterns of articular cartilage following growth plate injury in rats. Journal Orthop Sci 2009; 14: 646-651.

- Peláez Romero R, Alonso Chico A, Quintana Villamandos B, GArcía de Lucas E. Anestesia subaracnoidea para una cesárea urgente en la enfermedad de Charcot-Marie-Tooth. Rev Esp Anestesiol Reanim 2003;50:60-61.

- Garutti I, Quintana B, Olmedilla L, Cruz A, Barranco M, García de Lucas E. Respuesta de los autores. Anesth Analg 1999;89:1326-1334.

- Garutti I, Quintana B, Olmedilla L, Cruz A, Barranco M, García de Lucas E. Arterial oxygenation during one-lung ventilation: combined versus general anesthesia. Anesth Analg 1999;88:494-499.

- Quintana-Villamandos B, Garutti martínez I, Cruz Moratinos A, Avellanal calzadilla M, Vçazquel pelillo JC, Barranco Benito MC. Diagnóstico intraoperatorio de un paraganglioma mediastínico: manejo anestésico. Rev Esp Anestesiol Reanim 1999;46:165-168.

- Quintana-Villamandos B, Garutti-martínez I, Ferrando-Jordá A, Olmedilla-Arnal L. Comentarios sobre la anestesia epidural torácica asociada a anestesia general en un caso de miastenia grave. Respuesta de los autores. Rev Esp Anestesiol Reanim 1997;44:47.

- Quintana-Villamandos B, Garutti-martínez I, Clae de Alba B, Fernández López R, Ferrando-Jordá A, Olmedilla-Arnal L. Anestesia epidural torácica combinada con anestesia general con propofol para la timectomía en la miastenia grave. Rev Esp Anestesiol Reanim 1997;44:50.

 

LIBROS/CAPÍTULOS DE LIBROS

-Begoña Quintana, Ana Arnalich. Libro: "Estrategias de respuesta en la enseñanza ante los desafíos irruptivos". Utilidad de un programa docente traslacional en el aprendizaje de la ecocardiografía en la detección de la cardiopatía hipertensiva. Editorial: PETER LANG (2023). ISBN 978-3-631-91609-4.

-Paloma Morillas Sendín, Juan Francisco del Cañizo, Manuel Ruiz, Emilio Delgado-Baeza, Begoña Quintana Villamandos. Libro: "Issues and Development in Medicine and Medical Research, Vol.4. Study on the Effects of Sevoflurane and Propofol on Reperfusion after Partial Thoracic Aortic Cross-Clamping: Is Sevoflurane Superior to Propofol in Relation to Blood Flow and Markers of Tissue Injury and Inflammation? Editorial: BP International (2022). ISBN 978-93-5547-448-3 (Print), ISBN 978-93-5547-456-8 (eBook).

-Libro. Irene González Del Pozo, Begoña Quintana Villamandos. Biomarcadores de estrés oxidativo y capacidad antioxidante. Editorial Académica española (2020). ISBN: 978-620-0-41395-6.

- Laia Pazó-Sayós, Ana Arnalich-Montiel, Dayana Flórez-Palacio, Begoña Quintana-Villamandos. Libro: “Vascular Surgery”. Latest Recommendations on the Anesthetic Manage­ment of the Symptomatic Carotid Artery Disease. Editorial: SM Group Open Access eBooks (2019). ISBN: 978-1-944685-58-4

- Begoña Quintana-Villamandos, Ana Arnalich-Montiel, María Barrio, Laia Pazó-Sayós, Carmen Fernández-Riveira. Libro: “Vascular Surgery”. Capítulo. “Advances in anesthesia for endovascular aortic aneurysm repair”. Editorial: SM Group Open Access eBooks (2018). ISBN: 978-1-944685-58-4. 

- Begoña Quintana Villamandos, Ana Arnalich Montiel, Laia Pazó Sayós, Diego Monzó, Alejandro Garrido. Libro: “Ventricular Assist Devices”. Capítulo. “Extracorporeal Membrane Oxygenation support following cardiac and respiratory disease. Review”. Editorial: SM Group Open Access eBooks (2017). ISBN: 978-1-944685-59-1. 

- Mario Iglesias de la Vega, Guillermo Juan Rodriguez Bernal, Paloma Morillas, Begoña Quintana Villamandos Libro: “Ventricular Assist Devices”. Capítulo “Ventricular assist devices for patients for non-cardiac surgery”. Editorial: SM Group Open Access eBooks (2016). ISBN: 978-1-944685-59-1.

- Begoña Quintana Villamandos, Paloma Morillas, Guillermo Juan Rodríguez, Mario Iglesias de la Vega. Libro: “Ventricular Assist Devices”. Capítulo “Anesthesia for patients undergoing ventricular assist devices implantation. Review”. Editorial: SM Group Open Access eBooks (2016). ISBN: 978-1-944685-59-1.

- Rodríguez JR, Yuste AS, Ferrando A, Quintana B. Libro: “Fisiología aplicada a la Anestesiología”, de la ESA. (European Society of Anaesthesiology), CEEA (Comité for European Education in Anaesthesiology) Capítulo: “Inmunología y respuesta neuroendocrina al estrés en anestesia y cuidados críticos”. 257-268. Editorial: Ergon (2012). ISBN: 978-84-8473-997-5.

- Quintana B, Barranco M, Riesgo M. Libro: “Guía del dolor agudo postoperatorio”.  Capítulo: “Analgesia postoperatoria en cirugía cardiaca”. 197-209. Editorial: Ergon (2006). ISBN: 84-8473-400-5.

- Rodríguez JR, Yuste AS, Ferrando A, Quintana B. Libro: “Fisiología aplicada a la Anestesiología”, de la F.E.E.A. (Fundación Europea para la enseñanza de la Anestesiología en la formación continuada). Capítulo: “Inmunología y respuesta neuroendocrina al estrés en anestesia y cuidados críticos”. 431-452. Editorial: Ergon (2005). ISBN: 84-8473-336-X.

- De la Puerta E, Quintana B, Forés G. Libro:“Manual de Medicina Preoperatoria”. Capítulo:  “Enfermedades del eje hipotálamo-hipofisario”. 99-104. Editorial: Ergon (2004). ISBN: 84-8473-270-3.

- Quintana B, de la Puerta E. Libro:“Manual de Medicina Preoperatoria”. Capítulo: “Enfermedades Autoinmunes”. 187-202. Editorial: Ergon (2004). ISBN: 84-8473-270-3.

- Quintana B, Barranco M, del Castillo T. ”Manual de Medicina Preoperatoria”, CIRSA, 1999 Madrid.     Enfermedades Autoinmunes”.Pág. 147-158.

- Barranco M, Quintana B, Bardina A.“Manual de Medicina Preoperatoria”,CIRSA, 1999 Madrid.    “DiabetesMellitus”.Pág. 119-124.

- Díaz Ruano J, del Castillo T, Quintana B. “Manual de Medicina Preoperatoria”, CIRSA, 1999 Madrid. “Alteraciones del sistema del complemento”.Pág. 159-162.

- Fraile JR, Ferrando A, Quintana B. “Respuesta neuroendocrina e inmunológica a la anestesia y la cirugía”. “Fisiología aplicada a la Anestesiología”, de la F.E.E.A. (Fundación Europea para la enseñanza de la Anestesiología en la formación continuada). Madrid, 1996; 635-653.