Publicaciones relacionadas con las principales líneas de investigación

1.      Rubio-Araiz A, Porcu F, Pérez-Hernández M, García-Gutiérrez MS, Aracil-Fernández MA, Gutierrez-López MD, Guerri C, Manzanares J, O'Shea E, Colado MI. Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model. Addict Biol. 2016 Mar 7. doi: 10.1111/adb.12376. [Epub ahead of print] PubMed PMID: 26949123.

2.      Rodríguez-Arias M, Montagud-Romero S, Rubio-Araiz A, Aguilar MA, Martín-García E, Cabrera R, Maldonado R, Porcu F, Colado MI, Miñarro J. Effects of repeated social defeat on adolescent mice on cocaine-induced CPP and self-administration in adulthood: integrity of the blood-brain barrier. Addict Biol. 2015 Sep 16. doi: 10.1111/adb.12301. [Epub ahead of print] PubMed PMID: 26374627.

3.      Rubio-Araiz A, Perez-Hernandez M, Urrutia A, Porcu F, Borcel E, Gutierrez-Lopez MD, O'Shea E, Colado MI. 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier integrity through a mechanism involving P2X7 receptors. Int J Neuropsychopharmacol. 2014 Aug;17(8):1243-55. doi: 10.1017/S1461145714000145. Epub 2014 Mar 14. PubMed PMID: 24626059.

4.      O'Shea E, Urrutia A, Green AR, Colado MI. Current preclinical studies on neuroinflammation and changes in blood-brain barrier integrity by MDMA and methamphetamine. Neuropharmacology. 2014 Dec;87:125-34. doi: 10.1016/j.neuropharm.2014.02.015. Epub 2014 Mar 2. Review. PubMed PMID: 24594477.

5.      Urrutia A, Granado N, Gutierrez-Lopez MD, Moratalla R, O'Shea E, Colado MI. The JNK inhibitor, SP600125, potentiates the glial response and cell death induced by methamphetamine in the mouse striatum. Int J Neuropsychopharmacol. 2014 Feb;17(2):235-46. doi: 10.1017/S1461145713000850. Epub 2013 Oct 8. PubMed PMID: 24103647.

6.      Peraile I, Granado N, Torres E, Gutiérrez-López MD, Moratalla R, Colado MI, O'Shea E. Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders. Psychopharmacology (Berl). 2013 Nov;230(1):125-35. doi: 10.1007/s00213-013-3142-5. Epub 2013 May 17. PubMed PMID: 23681166.

7.      Urrutia A, Rubio-Araiz A, Gutierrez-Lopez MD, ElAli A, Hermann DM, O'Shea E, Colado MI. A study on the effect of JNK inhibitor, SP600125, on the disruption of blood-brain barrier induced by methamphetamine. Neurobiol Dis. 2013 Feb;50:49-58. doi: 10.1016/j.nbd.2012.10.006. Epub 2012 Oct 12. PubMed PMID: 23069681.

8.      ElAli A, Urrutia A, Rubio-Araiz A, Hernandez-Jimenez M, Colado MI, Doeppner TR, Hermann DM. Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication. Stroke. 2012 Jun;43(6):1647-53. doi: 10.1161/STROKEAHA.111.648923. Epub 2012 Mar 15. PubMed PMID: 22426312.

9.      Ares-Santos S, Granado N, Oliva I, O'Shea E, Martin ED, Colado MI, Moratalla R. Dopamine D(1) receptor deletion strongly reduces neurotoxic effects of methamphetamine. Neurobiol Dis. 2012 Feb;45(2):810-20. doi: 10.1016/j.nbd.2011.11.005. Epub 2011 Nov 13. PubMed PMID: 22115942.

10.   Mayado A, Torres E, Gutierrez-Lopez MD, Colado MI, O'Shea E. Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA. J Neuroinflammation. 2011 Nov 24;8:165. doi: 10.1186/1742-2094-8-165. PubMed PMID: 22114930; PubMed Central PMCID: PMC3283542.

11.   Torres E, Gutierrez-Lopez MD, Mayado A, Rubio A, O'Shea E, Colado MI. Changes in interleukin-1 signal modulators induced by 3,4-methylenedioxymethamphetamine (MDMA): regulation by CB2 receptors and implications for neurotoxicity. J Neuroinflammation. 2011 May 19;8:53. doi: 10.1186/1742-2094-8-53. PubMed PMID: 21595923; PubMed Central PMCID: PMC3113340.

12.   Granado N, Ares-Santos S, Oliva I, O'Shea E, Martin ED, Colado MI, Moratalla R. Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA. Neurobiol Dis. 2011 Jun;42(3):391-403. doi: 10.1016/j.nbd.2011.01.033. Epub 2011 Feb 15. PubMed PMID: 21303698.

13.   Gutierrez-Lopez MD, Llopis N, Feng S, Barrett DA, O'Shea E, Colado MI. Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine. Br J Pharmacol. 2010 Jun;160(3):772-83. doi: 10.1111/j.1476-5381.2010.00720.x. PubMed PMID: 20590579; PubMed Central PMCID: PMC2931575.

14.   Torres E, Gutierrez-Lopez MD, Borcel E, Peraile I, Mayado A, O'Shea E, Colado MI. Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain. J Neurochem. 2010 Apr;113(1):67-78. doi: 10.1111/j.1471-4159.2010.06578.x. Epub 2010 Jan 12. PubMed PMID: 20067581.

15.   Peraile I, Torres E, Mayado A, Izco M, Lopez-Jimenez A, Lopez-Moreno JA, Colado MI, O'Shea E. Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice. Br J Pharmacol. 2010 Jan;159(1):201-11. doi: 10.1111/j.1476-5381.2009.00522.x. Epub 2009 Dec 10. PubMed PMID: 20015297; PubMed Central PMCID: PMC2823365.

16.   Izco M, Gutierrez-Lopez MD, Marchant I, O'Shea E, Colado MI. Administration of neurotoxic doses of MDMA reduces sensitivity to ethanol and increases GAT-1 immunoreactivity in mice striatum. Psychopharmacology (Berl). 2010 Jan;207(4):671-9. doi: 10.1007/s00213-009-1699-9. Epub 2009 Oct 20. PubMed PMID: 19841904.

17.   Orio L, Llopis N, Torres E, Izco M, O'Shea E, Colado MI. A study on the mechanisms by which minocycline protects against MDMA ('ecstasy')-induced neurotoxicity of 5-HT cortical neurons. Neurotox Res. 2010 Aug;18(2):187-99. doi: 10.1007/s12640-009-9120-3. Epub 2009 Sep 24. PubMed PMID: 19777321.

18.   Granado N, Ares-Santos S, O'Shea E, Vicario-Abejón C, Colado MI, Moratalla R. Selective vulnerability in striosomes and in the nigrostriatal dopaminergic pathway after methamphetamine administration : early loss of TH in striosomes after methamphetamine. Neurotox Res. 2010 Jul;18(1):48-58. doi: 10.1007/s12640-009-9106-1. Epub 2009 Sep 4. PubMed PMID: 19760475; PubMed Central PMCID: PMC2875475.

19.   Moreno-Sanz G, O'Shea E, Orio L, Escobedo I, González-Cuevas G, Navarro M, Colado MI, López-Moreno JA. Administration of MDMA to ethanol-deprived rats increases ethanol operant self-administration and dopamine release during reinstatement. Int J Neuropsychopharmacol. 2009 Aug;12(7):929-40. doi: 10.1017/S1461145709009912. Epub 2009 Feb 23. PubMed PMID: 19236733.

20.   Rubio M, de Miguel R, Fernández-Ruiz J, Gutiérrez-López D, Carai MA, Ramos JA. Effects of a short-term exposure to alcohol in rats on FAAH enzyme and CB1 receptor in different brain areas. Drug Alcohol Depend. 2009 Jan 1;99(1-3):354-8. doi: 10.1016/j.drugalcdep.2008.08.004. Epub 2008 Oct 14.

21.   Granado N, O'Shea E, Bove J, Vila M, Colado MI, Moratalla R. Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. J Neurochem. 2008 Nov;107(4):1102-12. doi: 10.1111/j.1471-4159.2008.05705.x. Epub 2008 Sep 24. PubMed PMID: 18823368.

22.   Izco M, Marchant I, Escobedo I, Peraile I, Delgado M, Higuera-Matas A, Olias O, Ambrosio E, O'Shea E, Colado MI. Mice with decreased cerebral dopamine function following a neurotoxic dose of MDMA (3,4-methylenedioxymethamphetamine, "Ecstasy") exhibit increased ethanol consumption and preference. J Pharmacol Exp Ther. 2007 Sep;322(3):1003-12. Epub 2007 May 25. PubMed PMID: 17526809.

23.   Escobedo I, Peraile I, Orio L, Colado MI, O'Shea E. Evidence for a role of Hsp70 in the neuroprotection induced by heat shock pre-treatment against 3,4-methylenedioxymethamphetamine toxicity in rat brain. J Neurochem. 2007 Jun;101(5):1272-83. Epub 2007 Feb 27. PubMed PMID: 17328712.

24.   O'Shea E, Colado MI. Factors contributing to the enhancement of MDMA-induced 5-HT depletion by ethanol: a reply to Byron and Cassel. Psychopharmacology (Berl). 2007 Mar;190(4):581-2. Epub 2007 Jan 19. PubMed PMID: 17235607.

25.   Izco M, Orio L, O'Shea E, Colado MI. Binge ethanol administration enhances the MDMA-induced long-term 5-HT neurotoxicity in rat brain. Psychopharmacology (Berl). 2007 Jan;189(4):459-70. Epub 2006 Oct 18. PubMed PMID: 17047928.

26.   O'Shea E, Orio L, Escobedo I, Sanchez V, Camarero J, Green AR, Colado MI. MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperature. Br J Pharmacol. 2006 Jul;148(6):778-85. Epub 2006 Jun 12. PubMed PMID: 16770327; PubMed Central PMCID: PMC1617070.

27.   Saadat KS, Elliott JM, Colado MI, Green AR. The acute and long-term neurotoxic effects of MDMA on marble burying behaviour in mice. J Psychopharmacol. 2006 Mar;20(2):264-71. PubMed PMID: 16510484.

28.   O'Shea E, Sanchez V, Orio L, Escobedo I, Green AR, Colado MI. 3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity. Neuroscience. 2005;135(4):1095-105. Epub 2005 Sep 13. PubMed PMID: 16165281.

29.   Green AR, O'Shea E, Saadat KS, Elliott JM, Colado MI. Studies on the effect of MDMA ('ecstasy') on the body temperature of rats housed at different ambient room temperatures. Br J Pharmacol. 2005 Sep;146(2):306-12. PubMed PMID: 15997230; PubMed Central PMCID: PMC1576268.

30.   O'Shea E, Escobedo I, Orio L, Sanchez V, Navarro M, Green AR, Colado MI. Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats. Neuropsychopharmacology. 2005 Jul;30(7):1312-23. PubMed PMID: 15688085.

31.   Escobedo I, O'Shea E, Orio L, Sanchez V, Segura M, de la Torre R, Farre M, Green AR, Colado MI. A comparative study on the acute and long-term effects of MDMA and 3,4-dihydroxymethamphetamine (HHMA) on brain monoamine levels after i.p. or striatal administration in mice. Br J Pharmacol. 2005 Jan;144(2):231-41. PubMed PMID: 15665862; PubMed Central PMCID: PMC1575997.

32.   Saadat KS, O'Shea E, Colado MI, Elliott JM, Green AR. The role of 5-HT in the impairment of thermoregulation observed in rats administered MDMA ('ecstasy') when housed at high ambient temperature. Psychopharmacology (Berl). 2005 Jun;179(4):884-90. Epub 2005 Jan 14. PubMed PMID: 15650843.

33.   Green AR, O'Shea E, Colado MI. A review of the mechanisms involved in the acute MDMA (ecstasy)-induced hyperthermic response. Eur J Pharmacol. 2004 Oct 1;500(1-3):3-13. Review. PubMed PMID: 15464016.

34.   Sanchez V, O'Shea E, Saadat KS, Elliott JM, Colado MI, Green AR. Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neurones. J Psychopharmacol. 2004 Sep;18(3):412-6. PubMed PMID: 15358986.

35.   Orio L, O'Shea E, Sanchez V, Pradillo JM, Escobedo I, Camarero J, Moro MA, Green AR, Colado MI. 3,4-Methylenedioxymethamphetamine increases interleukin-1beta levels and activates microglia in rat brain: studies on the relationship with acute hyperthermia and 5-HT depletion. J Neurochem. 2004 Jun;89(6):1445-53. PubMed PMID: 15189347.

36.   Colado MI, O'Shea E, Green AR. Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function. Psychopharmacology (Berl). 2004 May;173(3-4):249-63. Epub 2004 Apr 9. Review. PubMed PMID: 15083264.

37.   Sumnall HR, O'Shea E, Marsden CA, Cole JC. The effects of MDMA pretreatment on the behavioural effects of other drugs of abuse in the rat elevated plus-maze test. Pharmacol Biochem Behav. 2004 Apr;77(4):805-14. PubMed PMID: 15099927.

38.   Green AR, Sanchez V, O'Shea E, Saadat KS, Elliott JM, Colado MI. Effect of ambient temperature and a prior neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA) on the hyperthermic response of rats to a single or repeated ('binge' ingestion) low dose of MDMA. Psychopharmacology (Berl). 2004 May;173(3-4):264-9. Epub 2004 Jan 15. PubMed PMID: 14726996.

39.   Saadat KS, Elliott JM, Colado MI, Green AR. Hyperthermic and neurotoxic effect of 3,4-methylenedioxymethamphetamine (MDMA) in guinea pigs. Psychopharmacology (Berl). 2004 May;173(3-4):452-3. Epub 2003 Dec 9. PubMed PMID:14663549.

40.   Green AR, Mechan AO, Elliott JM, O'Shea E, Colado MI. The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Pharmacol Rev. 2003 Sep;55(3):463-508. Epub 2003 Jul 17. Review. PubMed PMID: 12869661.

41.   O'Shea E, Colado MI. Is frequent dosing with ecstasy a risky business for dopamine-containing neurons? Trends Pharmacol Sci. 2003 Jun;24(6):272-4. PubMed PMID: 12823951.

42.   Easton N, Fry J, O'Shea E, Watkins A, Kingston S, Marsden CA. Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy). Brain Res. 2003 Oct 17;987(2):144-54. PubMed PMID: 14499958.

43.   Sanchez V, Zeini M, Camarero J, O'Shea E, Bosca L, Green AR, Colado MI. The nNOS inhibitor, AR-R17477AR, prevents the loss of NF68 immunoreactivity induced by methamphetamine in the mouse striatum. J Neurochem. 2003 Apr;85(2):515-24. PubMed PMID: 12675928.

44.   Sanchez V, Camarero J, O'Shea E, Green AR, Colado MI. Differential effect of dietary selenium on the long-term neurotoxicity induced by MDMA in mice and rats. Neuropharmacology. 2003 Mar;44(4):449-61. PubMed PMID: 12646282.

45.   O'Shea E, Sanchez V, Camarero J, Green AR, Colado MI. On the protection against methamphetamine-induced neurotoxicity by benzamide, a PARP inhibitor. Psychopharmacology (Berl). 2003 Jan;165(3):317-9. Epub 2002 Nov 30. PubMed PMID: 12459932.

46.   Cole JC, Sumnall HR, O'Shea E, Marsden CA. Effects of MDMA exposure on the conditioned place preference produced by other drugs of abuse. Psychopharmacology (Berl). 2003 Apr;166(4):383-90. Epub 2003 Feb 25. PubMed PMID: 12601504.

47.   O'Shea E, Easton N, Fry JR, Green AR, Marsden CA. Protection against 3,4-methylenedioxymethamphetamine-induced neurodegeneration produced by glutathione depletion in rats is mediated by attenuation of hyperthermia. J Neurochem. 2002 May;81(4):686-95. PubMed PMID: 12065628.

48.   Camarero J, Sanchez V, O'Shea E, Green AR, Colado MI. Studies, using in vivo microdialysis, on the effect of the dopamine uptake inhibitor GBR 12909 on 3,4-methylenedioxymethamphetamine ('ecstasy')-induced dopamine release and free radical formation in the mouse striatum. J Neurochem. 2002 Jun;81(5):961-72. PubMed PMID: 12065608.

49.   Mechan AO, Esteban B, O'Shea E, Elliott JM, Colado MI, Green AR. The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats. Br J Pharmacol. 2002 Jan;135(1):170-80. PubMed PMID: 11786492; PubMed Central PMCID: PMC1573106.

50.   Colado MI, Camarero J, Mechan AO, Sanchez V, Esteban B, Elliott JM, Green AR. A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain. Br J Pharmacol. 2001 Dec;134(8):1711-23. PubMed PMID: 11739248; PubMed Central PMCID: PMC1572911.

51.   Sanchez V, Camarero J, Esteban B, Peter MJ, Green AR, Colado MI. The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecstasy')-induced degeneration of 5-HT nerve endings in rat brain. Br J Pharmacol. 2001 Sep;134(1):46-57. PubMed PMID: 11522596; PubMed Central PMCID: PMC1572928.

52.   Colado MI, O'Shea E, Esteban B, Green AR. Studies on the neuroprotective effect of the enantiomers of AR-A008055, a compound structurally related to clomethiazole, on MDMA ("ecstasy")-induced neurodegeneration in rat brain. Psychopharmacology (Berl). 2001 Aug;157(1):82-8. PubMed PMID: 11512047.

53.   Mechan AO, O'Shea E, Elliott JM, Colado MI, Green AR. A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation. Psychopharmacology (Berl). 2001 Jun;155(4):413-8. PubMed PMID: 11441431.

54.   Esteban B, O'Shea E, Camarero J, Sanchez V, Green AR, Colado MI. 3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose. Psychopharmacology (Berl). 2001 Mar;154(3):251-60. PubMed PMID: 11351932.

55.   O'Shea E, Esteban B, Camarero J, Green AR, Colado MI. Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain. Neuropharmacology. 2001;40(1):65-74. PubMed PMID: 11077072.

56.   Colado MI, Granados R, O'Shea E, Esteban B, Green AR. The acute effect in rats of 3,4-methylenedioxyethamphetamine (MDEA, "eve") on body temperature and long term degeneration of 5-HT neurones in brain: a comparison with MDMA ("ecstasy"). Pharmacol Toxicol. 1999 Jun;84(6):261-6. PubMed PMID: 10401727.

57.   Colado MI, Esteban B, O'Shea E, Granados R, Green AR. Studies on the neuroprotective effect of pentobarbitone on MDMA-induced neurodegeneration. Psychopharmacology (Berl). 1999 Mar;142(4):421-5. PubMed PMID: 10229068.

58.   Colado MI, O'Shea E, Esteban B, Granados R, Green AR. In vivo evidence against clomethiazole being neuroprotective against MDMA ('ecstasy')-induced degeneration of rat brain 5-HT nerve terminals by a free radical scavenging mechanism. Neuropharmacology. 1999 Feb;38(2):307-14. PubMed PMID: 10218873.

59.   Colado MI, O'Shea E, Granados R, Esteban B, Martín AB, Green AR. Studies on the role of dopamine in the degeneration of 5-HT nerve endings in the brain of Dark Agouti rats following 3,4-methylenedioxymethamphetamine (MDMA or 'ecstasy') administration. Br J Pharmacol. 1999 Feb;126(4):911-24. PubMed PMID: 10193771; PubMed Central PMCID: PMC1571217.

60.   O'Shea E, Granados R, Esteban B, Colado MI, Green AR. The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('ecstasy'). Neuropharmacology. 1998 Jul;37(7):919-26. PubMed PMID: 9776387.

61.   Colado MI, Granados R, O'Shea E, Esteban B, Green AR. Role of hyperthermia in the protective action of clomethiazole against MDMA ('ecstasy')-induced neurodegeneration, comparison with the novel NMDA channel blocker AR-R15896AR. Br J Pharmacol. 1998 Jun;124(3):479-84. PubMed PMID: 9647471; PubMed Central PMCID: PMC1565414.

62.   Colado MI, O'Shea E, Granados R, Murray TK, Green AR. In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ('ecstasy') and p-chloroamphetamine but not the degeneration following fenfluramine. Br J Pharmacol. 1997 Jul;121(5):889-900. PubMed PMID: 9222545; PubMed Central PMCID: PMC1564770.

63.   Colado MI, O'Shea E, Granados R, Misra A, Murray TK, Green AR. A study of the neurotoxic effect of MDMA ('ecstasy') on 5-HT neurones in the brains of mothers and neonates following administration of the drug during pregnancy. Br J Pharmacol. 1997 Jun;121(4):827-33. PubMed PMID: 9208155; PubMed Central PMCID: PMC1564752.

64.   Murray TK, Williams JL, Misra A, Colado MI, Green AR. The spin trap reagent PBN attenuates degeneration of 5-HT neurones in rat brain induced by p-chloroamphetamine but not fenfluramine. Neuropharmacology. 1996;35(11):1615-20. PubMed PMID: 9025109.

65.   Colado MI, Williams JL, Green AR. The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4 methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. Br J Pharmacol. 1995 Aug;115(7):1281-9. PubMed PMID: 7582557; PubMed Central PMCID: PMC1908797.

66.   Colado MI, Green AR. The spin trap reagent alpha-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones. Eur J Pharmacol. 1995 Jul 14;280(3):343-6. PubMed PMID: 8566105.

67.   Colado MI, Green AR. A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds. Br J Pharmacol. 1994 Jan;111(1):131-6. PubMed PMID: 7516800; PubMed Central PMCID: PMC1910050.

68.   Snape MF, Colado MI, Green AR. Chlormethiazole and dizocilpine block the behavioural, but not the neurotoxic effects of 5,7-dihydroxytryptamine in mice. Pharmacol Toxicol. 1994 Jan;74(1):40-2. PubMed PMID: 7512715.

69.   Baldwin HA, Colado MI, Murray TK, De Souza RJ, Green AR. Striatal dopamine release in vivo following neurotoxic doses of methamphetamine and effect of the neuroprotective drugs, chlormethiazole and dizocilpine. Br J Pharmacol. 1993 Mar;108(3):590-6. PubMed PMID: 8467354; PubMed Central PMCID: PMC1908047.

 

Otras publicaciones

70.   Gilsanz A, Sánchez-Martín L, Gutiérrez-López MD, Ovalle S, Machado-Pineda Y,Reyes R, Swart GW, Figdor CG, Lafuente EM, Cabañas C. ALCAM/CD166 adhesive function is regulated by the tetraspanin CD9. Cell Mol Life Sci. 2013 Feb;70(3):475-93. doi: 10.1007/s00018-012-1132-0. Epub 2012 Sep 30. PubMed PMID: 23052204.

71.   Yáñez-Mó M, Gutiérrez-López MD, Cabañas C. Functional interplay between tetraspanins and proteases. Cell Mol Life Sci. 2011 Oct;68(20):3323-35. doi: 10.1007/s00018-011-0746-y. Epub 2011 Jun 18. Review. PubMed PMID: 21687991.

72.   Gutiérrez-López MD, Gilsanz A, Yáñez-Mó M, Ovalle S, Lafuente EM, Domínguez C, Monk PN, González-Alvaro I, Sánchez-Madrid F, Cabañas C. The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9. Cell Mol Life Sci. 2011 Oct;68(19):3275-92. doi: 10.1007/s00018-011-0639-0. Epub 2011 Mar 2. PubMed PMID: 21365281.

73.   Gómez C, Curto GG, Baltanás FC, Valero J, O'Shea E, Colado MI, Díaz D, Weruaga E, Alonso JR. Changes in the serotonergic system and in brain-derived neurotrophic factor distribution in the main olfactory bulb of pcd mice before and after mitral cell loss. Neuroscience. 2012 Jan 10;201:20-33. doi: 10.1016/j.neuroscience.2011.11.025. Epub 2011 Nov 20. PubMed PMID: 22133893.

74.   Llorente R, O'Shea E, Gutierrez-Lopez MD, Llorente-Berzal A, Colado MI, Viveros MP. Sex-dependent maternal deprivation effects on brain monoamine content in adolescent rats. Neurosci Lett. 2010 Jul 26;479(2):112-7. doi: 10.1016/j.neulet.2010.05.039. Epub 2010 May 20. PubMed PMID: 20493239.

75.   Riol-Blanco L, Delgado-Martín C, Sánchez-Sánchez N, Alonso-C LM, Gutiérrez-López MD, Del Hoyo GM, Navarro J, Sánchez-Madrid F, Cabañas C, Sánchez-Mateos P, Rodríguez-Fernández JL. Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells. Nat Immunol. 2009 Jul;10(7):753-60. doi: 10.1038/ni.1750. Epub 2009 Jun 7. Erratum in: Nat Immunol. 2010 Jun;11(6):543. PubMed PMID: 19503105.

76.   Ovalle S, Gutiérrez-López MD, Olmo N, Turnay J, Lizarbe MA, Majano P, Molina-Jiménez F, López-Cabrera M, Yáñez-Mó M, Sánchez-Madrid F, Cabañas C. The tetraspanin CD9 inhibits the proliferation and tumorigenicity of human colon carcinoma cells. Int J Cancer. 2007 Nov 15;121(10):2140-52. PubMed PMID: 17582603.

77.   Gómez C, Briñón JG, Valero J, Recio JS, Murias AR, Curto GG, Orio L, Colado MI, Alonso JR. Sex differences in catechol contents in the olfactory bulb of control and unilaterally deprived rats. Eur J Neurosci. 2007 Mar;25(5):1517-28. PubMed PMID: 17425578.

78.   Gómez C, Briñón JG, Orio L, Colado MI, Lawrence AJ, Zhou FC, Vidal M, Barbado MV, Alonso JR. Changes in the serotonergic system in the main olfactory bulb of rats unilaterally deprived from birth to adulthood. J Neurochem. 2007 Feb;100(4):924-38. PubMed PMID: 17266734.

79.   Gómez C, Briñón JG, Colado MI, Orio L, Vidal M, Barbado MV, Alonso JR.Differential effects of unilateral olfactory deprivation on noradrenergic and cholinergic systems in the main olfactory bulb of the rat. Neuroscience. 2006 Sep 15;141(4):2117-28. Epub 2006 Jun 30. PubMed PMID: 16809000.

80.   Maqueda A, Moyano JV, Gutiérrez-López MD, Ovalle S, Rodríguez-Frade JM, Cabañas C, Garcia-Pardo A. Activation pathways of alpha4beta1 integrin leading to distinct T-cell cytoskeleton reorganization, Rac1 regulation and Pyk2 phosphorylation. J Cell Physiol. 2006 Jun;207(3):746-56. PubMed PMID: 16514607.

81.   Barreiro O, Yáñez-Mó M, Sala-Valdés M, Gutiérrez-López MD, Ovalle S, Higginbottom A, Monk PN, Cabañas C, Sánchez-Madrid F. Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation. Blood. 2005 Apr 1;105(7):2852-61. Epub 2004 Dec 9. PubMed PMID: 15591117.

82.   Sánchez-Martín L, Sánchez-Sánchez N, Gutiérrez-López MD, Rojo AI, Vicente-Manzanares M, Pérez-Alvarez MJ, Sánchez-Mateos P, Bustelo XR, Cuadrado A, Sánchez-Madrid F, Rodríguez-Fernández JL, Cabañas C. Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1. J Biol Chem. 2004 Apr 16;279(16):16194-205. Epub 2004 Feb 11. PubMed PMID: 14960575.

83.   Gutierrez-Lopez MD, Ovalle S, Yanez-Mo M, Sanchez-Sanchez N, Rubinstein E, Olmo N, Lizarbe MA, Sanchez-Madrid F, Cabanas C. A functionally relevant conformational epitope on the CD9 tetraspanin depends on the association with activated beta1 integrin. J Biol Chem. 2003 Jan 3;278(1):208-18. Epub 2002 Oct 30. PubMed PMID: 12411441.

84.   Hurtado O, De Cristóbal J, Sánchez V, Lizasoain I, Cárdenas A, Pereira MP, Colado MI, Leza JC, Lorenzo P, Moro MA. Inhibition of glutamate release by delaying ATP fall accounts for neuroprotective effects of antioxidants in experimental stroke. FASEB J. 2003 Nov;17(14):2082-4. Epub 2003 Sep 18. PubMed PMID: 14500556.

85.   Cárdenas A, Moro MA, Leza JC, O'Shea E, Dávalos A, Castillo J, Lorenzo P, Lizasoain I. Upregulation of TACE/ADAM17 after ischemic preconditioning is involved in brain tolerance. J Cereb Blood Flow Metab. 2002 Nov;22(11):1297-302. PubMed PMID: 12439286.

86.   Esteban-Barragán MA, Avila P, Alvarez-Tejado M, Gutiérrez MD, García-Pardo A, Sánchez-Madrid F, Landázuri MO. Role of the von Hippel-Lindau tumor suppressor gene in the formation of beta1-integrin fibrillar adhesions. Cancer Res. 2002 May 15;62(10):2929-36. PubMed PMID: 12019174.

87.   Alfranca A, Gutiérrez MD, Vara A, Aragonés J, Vidal F, Landázuri MO. c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription. Mol Cell Biol. 2002 Jan;22(1):12-22. PubMed PMID: 11739718; PubMed Central PMCID: PMC134229.

88.   De Cristóbal J, Moro MA, Dávalos A, Castillo J, Leza JC, Camarero J, Colado MI, Lorenzo P, Lizasoain I. Neuroprotective effect of aspirin by inhibition of glutamate release after permanent focal cerebral ischaemia in rats. J Neurochem. 2001 Oct;79(2):456-9. PubMed PMID: 11677274.

89.   Gil D, Gutiérrez D, Alarcón B. Intracellular redistribution of nucleolin upon interaction with the CD3epsilon chain of the T cell receptor complex. J Biol Chem. 2001 Apr 6;276(14):11174-9. Epub 2000 Dec 13. PubMed PMID: 11115514.

90.   Miró X, Casacuberta JM, Gutiérrez-López MD, de Landázuri MO, Puigdomènech P. Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1). Biochem Biophys Res Commun. 2000 Aug 2;274(2):415-21. PubMed PMID: 10913353.

91.   Martínez ML, Fernández-Tomé P, López-Miranda V, Colado MI, Delgado C. Modulation of adrenergic receptors during left ventricular hypertrophy development and after regression by captopril. J Cardiovasc Pharmacol. 1999 Oct;34(4):505-11. PubMed PMID: 10511124.

92.   Serrano-Ríos M, Gutierrez-López MD, Pérez-Bravo F, Martínez MT, Antona J, Rowley M, Mackay I, Zimmet P. HLA-DR, DQ and anti-GAD antibodies in first degree  relatives of type I diabetes mellitus. Diabetes Res Clin Pract. 1996 Oct;34 Suppl:S133-9. PubMed PMID: 9015682.

93.   Martín MI, del Val VL, Colado MI, Goicoechea C, Alfaro MJ. Behavioral and analgesic effects induced by administration of nifedipine and nimodipine. Pharmacol Biochem Behav. 1996 Sep;55(1):93-8. PubMed PMID: 8870043.

94.   Perez-Bravo F, Carrasco E, Gutierrez-Lopez MD, Martinez MT, Lopez G, de los Rios MG. Genetic predisposition and environmental factors leading to the development of insulin-dependent diabetes mellitus in Chilean children. J Mol Med (Berl). 1996 Feb;74(2):105-9. PubMed PMID: 8820406.

95.   Viveros MP, de Cabo C, Colado MI, Martín MI. Naltrexone administration during the preweanling period affects striatal and hypothalamic serotonergic systems, but not midbrain serotonergic or striatal dopaminergic systems in the adult rat. Neurosci Lett. 1995 Dec 15;201(3):195-8. PubMed PMID: 8786838.

96.   Perez-Bravo F, Serrano-Rios M, Gutierrez-Lopez MD, Calvillan M, Garcia de los Rios M, Kocova M, Dorman J, Trucco M. Genetic analysis of HLA DRB1, DQA1 and DQB1 alleles and susceptibility to IDDM in Chilean subjects. Chile IDDM Study Group. Diabetologia. 1995 Mar;38(3):378-9. PubMed PMID: 7758887.

97.   Martinez MT, Ramos O, Carretero N, Calvillan M, Gutierrez-Lopez MD, Cuesta P, Serrano-Rios M. Lipoprotein (a) and other risk factors in children with insulin-dependent diabetes mellitus and children without diabetes. Diabete Metab. 1994 Nov-Dec;20(6):522-5. PubMed PMID: 7713274.

98.   Martinez MT, Ramos O, Carretero N, Calvillán M, Gutierrez-López MD, Cuesta P, Serrano-Ríos M. Lipoprotein (a) and other risk factors in children with insulin-dependent diabetes mellitus and children without diabetes. Diabete Metab. 1994 Sep-Oct;20(5):454-7. PubMed PMID: 7859892.

99.   Gutierrez-Lopez MD, Bertera S, Chantres MT, Vavassori C, Dorman JS, Trucco M, Serrano-Rios M. Susceptibility to type 1 (insulin-dependent) diabetes mellitus in Spanish patients correlates quantitatively with expression of HLA-DQ alpha Arg 52 and HLA-DQ beta non-Asp 57 alleles. Diabetologia. 1992 Jun;35(6):583-8. PubMed PMID: 1612233.

100. Colado MI, Ormazabal MJ, Goicoechea C, Lopez F, Alfaro MJ, Martin MI. Involvement of central serotonergic pathways in analgesia elicited by salmon calcitonin in the mouse. Eur J Pharmacol. 1994 Feb 11;252(3):291-7. PubMed PMID: 7512926.

101. De Cabo C, Colado MI, Pujol A, Martín MI, Viveros MP. Naltrexone administration effects on regional brain monoamines in developing rats. Brain Res Bull. 1994;34(4):395-406. PubMed PMID: 8082032.

102. Colado MI, Del Rio J, Peralta E. Neonatal guanethidine sympathectomy suppresses autotomy and prevents changes in spinal and supraspinal monoamine levels induced by peripheral deafferentation in rats. Pain. 1994 Jan;56(1):3-8. PubMed PMID: 7512708.

103. Lucas JJ, Mellström B, Colado MI, Naranjo JR. Molecular mechanisms of pain: serotonin1A receptor agonists trigger transactivation by c-fos of the prodynorphin gene in spinal cord neurons. Neuron. 1993 Apr;10(4):599-611. PubMed PMID: 8476611.

104. Martín MI, Alfaro MJ, Goicoechea C, Colado MI. In vitro study of the interaction of salmon calcitonin with mu, delta and kappa opioid agonists. Naunyn Schmiedebergs Arch Pharmacol. 1993 Mar;347(3):324-8. PubMed PMID: 8386807.

105. Colado MI, Ormazabal MJ, Alfaro MJ, Martin MI. Effect of Bay K 8644 on the synthesis and metabolism of dopamine and 5-hydroxytryptamine in various brain areas of the rat. J Pharm Pharmacol. 1993 Mar;45(3):220-2. PubMed PMID: 7683338.

106. Colado MI, Murray TK, Green AR. 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine. Br J Pharmacol. 1993 Mar;108(3):583-9. PubMed PMID: 7682129; PubMed Central PMCID: PMC1908028.

107. Colado MI, Alfaro MJ, Lopez F, Del Val V, Martin MI. Effect of nimodipine, diltiazem and BAY K 8644 on the behavioural and neurochemical changes associated with naloxone-precipitated withdrawal in the rat. A comparison with clonidine. Gen Pharmacol. 1993 Jan;24(1):35-41. PubMed PMID: 7683298.

108. Martín MI, Goicoechea C, Colado MI, Alfaro MJ. Analgesic effect of salmon-calcitonin administered by two routes. Effect on morphine analgesia. Eur J Pharmacol. 1992 Nov 24;224(1):77-82. PubMed PMID: 1451745.

109. Colado MI, Martin MI. Effects of opioid and alpha 2-adrenoceptor agonists on the isolated ileum of morphine-dependent guinea-pigs during withdrawal and after clonidine treatment. J Pharm Pharmacol. 1992 Feb;44(2):101-4. PubMed PMID: 1352807.

110. Colado MI, Alfaro MJ, López F, Del Val V, Martín MI. The effect of dihydropyridine calcium channel agents on 5-HT metabolism in the CNS of the rat. J Pharm Pharmacol. 1991 Sep;43(9):662-4. PubMed PMID: 1723099.

111. Martin MI, Colado MI, Alfaro MJ. Calcitonin increases the inhibitory effect of opioids in guinea-pig ileum. Gen Pharmacol. 1991;22(1):73-5. PubMed PMID: 2050289.

112. Colado MI, Alfaro MJ, del Val VL, Martín MI. Effect of cinitapride in isolated ileum obtained from guinea-pigs treated with morphine. Gen Pharmacol. 1991;22(5):863-6. PubMed PMID: 1662171.

113. Alfaro MJ, Colado MI, López F, Martín MI. Effect of clonidine, nimodipine and diltiazem on the in vitro opioid withdrawal response in the guinea-pig ileum. Br J Pharmacol. 1990 Dec;101(4):958-60. PubMed PMID: 2085717; PubMed Central PMCID: PMC1917837.

114. Alfaro MJ, Colado MI, Lopez F, Martin MI. Acute treatment with clonidine or calcium entry blockers on opioid withdrawal in guinea-pig ileum. J Pharm Pharmacol. 1990 Oct;42(10):743-4. PubMed PMID: 1982152.

115. Colado MI, Lorenzo P, Martín MI. Nifedipine reversal of decreased serotonin metabolite levels during morphine withdrawal. Arch Int Pharmacodyn Ther. 1989 Mar-Apr;298:61-7. PubMed PMID: 2474270.

116. Vaquero J, Martínez R, Oya S, Coca S, Salazar FG, Colado MI. Transplantation of adrenal medulla into spinal cord for pain relief: disappointing outcome. Lancet. 1988 Dec 3;2(8623):1315. PubMed PMID: 2461500.

117. Colado MI, Arnedo A, Peralta E, Del Río J. Unilateral dorsal rhizotomy decreases monoamine levels in the rat spinal cord. Neurosci Lett. 1988 May 3;87(3):302-6. PubMed PMID: 2454430.

118. Martín MI, Aleixandre MA, Colado MI, García de Jalón PD. Sensitivity of the myenteric plexus alpha2-receptor from guinea pig treated with clonidine or guanfacine. Arch Farmacol Toxicol. 1984 Aug;10(2):115-9. PubMed PMID: 6097196.

119. Aleixandre MA, Colado MI, García de Jalón PD, Martín MI. Influences on morphine action in the myenteric plexus from guinea pig of alpha 2 receptor stimulation. Arch Farmacol Toxicol. 1983 Dec;9(3):217-24. PubMed PMID: 6143536.