Research Lines
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Study of Candida - host interaction:
- Characterization of new virulence factors
- Study of the molecular mechanisms activated in the host immune response.
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Search of new biomarkers for diagnosis and prognosis for Invasive Candidiasis and search of new putative vaccination targets.
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High throughput Proteomics, based on shotgun strategies, to acquire a global overview of the Candida and its host proteomes upon interaction.
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Targeted Proteomics, based on Selected Reaction Monitoring (SRM), to study diverse cellular processes such as apoptosis and to validate and quantitate selected proteins of interest.
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Study of the set of Candida proteins that make contact with the host in the first place: surfome, secretome and vesicle integrating proteins .
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Development of methods for diagnosis of other infectious diseases.
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Participation in the spanish consortium for the study of the Human Proteome (Human Proteome Project - HPP).
- Expression of unknown proteins
- Development of SRM methods to detect proteins encoded in chromosome 16 (chromosome-centric HPP, C-HPP).
- Integration of the acquired methods with the Biology/Disease del HPP (B/D-HPP) branch of the project by studying proteins involved in the defence against fungal infections