research

Research Lines

Direct Neurobacterial Interactions:
We develop in vitro models to study how live and inactivated gut bacteria, such as Lactiplantibacillus plantarum, interact with mammalian neurons. Our platforms allow the assessment of morphological, functional, and transcriptomic changes in neurons upon direct bacterial contact.
Bacterial Bioelectricity and Electrome Profiling:
We explore the membrane potential (Vmem) dynamics of gut-relevant bacterial strains (e.g., E. coli, Enterococcus faecalis) and how these change in response to neurotransmitters like glutamate and GABA. These studies provide novel insights into bacterial sensory systems and inter-kingdom bioelectric signaling.
Microbiota-Driven Neuroplasticity:
We investigate the influence of bacterial presence on neuronal bioelectrical activity, synaptic markers (e.g., Synapsin I, pCREB), and transcriptional responses. These findings support the idea that gut bacteria can modulate brain plasticity through non-classical pathways.
Computational Modeling of the Gut–Brain Axis:
Using systems biology and computational tools, we model bacterial–neuronal interactions, analyze transcriptomic networks, and simulate bioelectric communication as a conserved signaling language across life domains.

Projects and Collaborations

Our research is supported by national (the Spanish Ministry of Science and Innovation through PID2023-147361NA-I00 and the Ramón y Cajal program (RYC2020-029499-I, from the MICINN, FSE/ Agencia Estatal de Investigación) and European funding programs and is rooted in strong collaborations with leading institutions. In particular, we work closely with the University of Turin (Italy), Universidad de Zaragoza (Spain), and Tufts University (USA).

Our current projects focus on the development of neurobiotics, microbiota-based therapeutics, and bioelectrical interventions for neurological disorders, with an emphasis on understanding and modulating the microbiota–brain axis. These projects combine experimental neurobiology, microbiology, and computational modeling to uncover novel strategies for brain health and disease treatment.

Together with our international collaborators, we are advancing a new frontier in neuroscience by exploring how microbial signals, including bioelectric cues, influence neural function and behavior.

Opportunities

We welcome undergraduate, master's, and PhD students with a strong interest in interdisciplinary research bridging microbiology, neuroscience, and computational biology. For inquiries about internships or collaboration opportunities, please contact us.