• 2022

 

Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke

Endres M, Moro MA, Nolte CH, Dames C, Buckwalter MS, Meisel A. 

Circ Res. 2022 Apr 15;130(8):1167-1186. doi: 10.1161/CIRCRESAHA.121.319994. Epub 2022 Apr 14. PMID: 35420915

 

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa

Sánchez-Cruz A, Hernández-Pinto A, Lillo C, Isiegas C, Marchena M, Lizasoain I, Bosch F, de la Villa P, Hernández-Sánchez C, de la Rosa EJ.

Cell Death Dis. 2022 Apr 20;13(4):383. doi: 10.1038/s41419-022-04839-0. PMID: 35444190

 

First-in-human phase I clinical trial of a TLR4-binding DNA aptamer, ApTOLL: Safety and pharmacokinetics in healthy volunteers

Hernández-Jiménez M, Martín-Vílchez S, Ochoa D, Mejía-Abril G, Román M, Camargo-Mamani P, Luquero-Bueno S, Jilma B, Moro MA, Fernández G, Piñeiro D, Ribó M, González VM, Lizasoain I, Abad-Santos F. 

Mol Ther Nucleic Acids. 2022 Mar 9;28:124-135. doi: 10.1016/j.omtn.2022.03.005. eCollection 2022 Jun 14. PMID: 35402075

 

Neutrophil Extracellular Trap Targeting Protects Against Ischemic Damage After Fibrin-Rich Thrombotic Stroke Despite Non-Reperfusion

Peña-Martínez C, Durán-Laforet V, García-Culebras A, Cuartero MI, Moro MÁ, Lizasoain I.

Front Immunol. 2022 Feb 16;13:790002. doi: 10.3389/fimmu.2022.790002. eCollection 2022. PMID: 35250974

 

Cav-1 Protein Levels in Serum and Infarcted Brain Correlate with Hemorrhagic Volume in a Mouse Model of Thromboembolic Stroke, Independently of rt-PA Administration

Gubern-Mérida C, Comajoan P, Huguet G, García-Yebenes I, Lizasoain I, Moro MA, Puig-Parnau I, Sánchez JM, Serena J, Kádár E, Castellanos M.

Mol Neurobiol. 2022 Feb;59(2):1320-1332. doi: 10.1007/s12035-021-02644-y. Epub 2022 Jan 5. PMID: 34984586

 

• 2021

 

Role of TLR4 in Neutrophil Dynamics and Functions: Contribution to Stroke Pathophysiology

Durán-Laforet V, Peña-Martínez C, García-Culebras A, Cuartero MI, Lo EH, Moro MÁ, Lizasoain I.

Front Immunol. 2021 Oct 21;12:757872. doi: 10.3389/fimmu.2021.757872. eCollection 2021. PMID: 34745132

 

Translational Interdisciplinary Science-Immune Cell Niches: Possible Targets for Stroke Therapy?

McCullough LD, Moro MA.

Stroke. 2021 Nov;52(11):3692-3695. doi: 10.1161/STROKEAHA.121.033969. Epub 2021 Oct 8. PMID: 34619983

 

Pathophysiological and pharmacological relevance of TLR4 in peripheral immune cells after stroke

Durán-Laforet V, Peña-Martínez C, García-Culebras A, Alzamora L, Moro MA, Lizasoain I.

Pharmacol Ther. 2021 Dec;228:107933. doi: 10.1016/j.pharmthera.2021.107933. Epub 2021 Jun 24. PMID: 34174279

 

Tlr2 Gene Deletion Delays Retinal Degeneration in Two Genetically Distinct Mouse Models of Retinitis Pigmentosa

Sánchez-Cruz A, Méndez AC, Lizasoain I, de la Villa P, de la Rosa EJ, Hernández-Sánchez C. 

Int J Mol Sci. 2021 Jul 22;22(15):7815. doi: 10.3390/ijms22157815. PMID: 34360582

 

Influence of metabolic syndrome on post-stroke outcome, angiogenesis and vascular function in old rats determined by dynamic contrast enhanced MRI

Pradillo JM, Hernández-Jiménez M, Fernández-Valle ME, Medina V, Ortuño JE, Allan SM, Proctor SD, Garcia-Segura JM, Ledesma-Carbayo MJ, Santos A, Moro MA, Lizasoain I.

J Cereb Blood Flow Metab. 2021 Jul;41(7):1692-1706. doi: 10.1177/0271678X20976412. Epub 2020 Dec 1. PMID: 34152893

 

Circadian Biology and Stroke

Lo EH, Albers GW, Dichgans M, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadžić S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AM.

Stroke. 2021 Jun;52(6):2180-2190. doi: 10.1161/STROKEAHA.120.031742. Epub 2021 May 4. PMID: 33940951

 

Post-stroke Neurogenesis: Friend or Foe?

Cuartero MI, García-Culebras A, Torres-López C, Medina V, Fraga E, Vázquez-Reyes S, Jareño-Flores T, García-Segura JM, Lizasoain I, Moro MÁ.

Front Cell Dev Biol. 2021 Mar 23;9:657846. doi: 10.3389/fcell.2021.657846. eCollection 2021. PMID: 33834025

 

Recent advances in the pathogenesis and therapeutics of amyotrophic lateral sclerosis

Fernández-Ruiz J, de Lago E, Rodríguez-Cueto C, Moro MA.

Br J Pharmacol. 2021 Mar;178(6):1253-1256. doi: 10.1111/bph.15348. PMID: 33638898

 

Effective glutamate clearance from the systemic circulation by hemodialysis: Potential relevance for cerebral ischemia management

Martínez-Miguel P, Albalate M, Durán-Laforet V, Peña-Martínez C, de Sequera P, Bouarich H, Peña-Esparragoza K, López-Ongil S, Lizasoain I, Sánchez-Prieto J, Torres M, Moro MÁ, Rodríguez-Puyol D.

Artif Organs. 2021 Oct;45(10):1183-1188. doi: 10.1111/aor.13933. Epub 2021 Mar 28. PMID: 33560549

 

Retinal Thickness Changes Over Time in a Murine AD Model APP ^NL-F/NL-F

Salobrar-García E, López-Cuenca I, Sánchez-Puebla L, de Hoz R, Fernández-Albarral JA, Ramírez AI, Bravo-Ferrer I, Medina V, Moro MA, Saido TC, Saito T, Salazar JJ, Ramírez JM.

Front Aging Neurosci. 2021 Jan 15;12:625642. doi: 10.3389/fnagi.2020.625642. eCollection 2020. PMID: 33542683 Free PMC article

 

New Mechanistic Insights, Novel Treatment Paradigms, and Clinical Progress in Cerebrovascular Diseases

Boltze J, Aronowski JA, Badaut J, Buckwalter MS, Caleo M, Chopp M, Dave KR, Didwischus N, Dijkhuizen RM, Doeppner TR, Dreier JP, Fouad K, Gelderblom M, Gertz K, Golubczyk D, Gregson BA, Hamel E, Hanley DF, Härtig W, Hummel FC, Ikhsan M, Janowski M, Jolkkonen J, Karuppagounder SS, Keep RF, Koerte IK, Kokaia Z, Li P, Liu F, Lizasoain I, Ludewig P, Metz GAS, Montagne A, Obenaus A, Palumbo A, Pearl M, Perez-Pinzon M, Planas AM, Plesnila N, Raval AP, Rueger MA, Sansing LH, Sohrabji F, Stagg CJ, Stetler RA, Stowe AM, Sun D, Taguchi A, Tanter M, Vay SU, Vemuganti R, Vivien D, Walczak P, Wang J, Xiong Y, Zille M.

Front Aging Neurosci. 2021 Jan 28;13:623751. doi: 10.3389/fnagi.2021.623751. eCollection 2021. PMID: 33584250

• 2020

 

Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation

Adrover JM, Aroca-Crevillén A, Crainiciuc G, Ostos F, Rojas-Vega Y, Rubio-Ponce A, Cilloniz C, Bonzón-Kulichenko E, Calvo E, Rico D, Moro MA, Weber C, Lizasoain I, Torres A, Ruiz-Cabello J, Vázquez J, Hidalgo A.

Nat Immunol. 2020 Jan 13. doi: 10.1038/s41590-019-0571-2. PubMed PMID: 31932813

• 2019

 

Pharmacological Modulation of Neutrophil Extracellular Traps Reverses Thrombotic Stroke tPA (Tissue-Type Plasminogen Activator) Resistance

Peña-Martínez C, Durán-Laforet V, García-Culebras A, Ostos F, Hernández-Jiménez M, Bravo-Ferrer I, Pérez-Ruiz A, Ballenilla F, Díaz-Guzmán J, Pradillo JM, Lizasoain I, Moro MA.

Stroke. 2019 Nov;50(11):3228-3237. doi:10.1161/STROKEAHA.119.026848. PubMed PMID: 31526124.

 

Lack of the aryl hydrocarbon receptor accelerates aging in mice

Bravo-Ferrer I, Cuartero MI, Medina V, Ahedo-Quero D, Peña-Martínez C, Pérez-Ruíz A, Fernández-Valle ME, Hernández-Sánchez C, Fernández-Salguero PM, Lizasoain I, Moro MA.

FASEB J. 2019 Nov;33(11):12644-12654. doi: 10.1096/fj.201901333R. PubMed PMID: 31483997.

 

Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke

García-Culebras A, Durán-Laforet V, Peña-Martínez C, Moraga A, Ballesteros I, Cuartero MI, de la Parra J, Palma-Tortosa S, Hidalgo A, Corbí AL, Moro MA, Lizasoain I.

Stroke. 2019 Oct;50(10):2922-2932. doi: 10.1161/STROKEAHA.119.025085. PubMed PMID: 31451099.

 

Delayed Effects of Acute Reperfusion on Vascular Remodeling and Late-Phase Functional Recovery After Stroke

Durán-Laforet V, Fernández-López D, García-Culebras A, González-Hijón J, Moraga A, Palma-Tortosa S, García-Yébenes I, Vega-Pérez A, Lizasoain I, Moro MÁ.

Front Neurosci. 2019 Jul 23;13:767. doi: 10.3389/fnins.2019.00767. PubMed PMID: 31396042.

 

Toll-like receptor 4 regulates subventricular zone proliferation and neuroblast migration after experimental stroke

Palma-Tortosa S, Hurtado O, Pradillo JM, Ferreras-Martín R, García-Yébenes I, García-Culebras A, Moraga A, Moro MÁ, Lizasoain I.

Brain Behav Immun. 2019 Aug;80:573-582. doi: 10.1016/j.bbi.2019.05.002. PubMed PMID: 31059808.

 

Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice

Cuartero MI, de la Parra J, Pérez-Ruiz A, Bravo-Ferrer I, Durán-Laforet V, García-Culebras A, García-Segura JM, Dhaliwal J, Frankland PW, Lizasoain I, Moro MÁ.

J Clin Invest. 2019 Apr 1;129(4):1536-1550. doi: 10.1172/JCI120412. PubMed PMID: 30676325.

 

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

Adrover JM, Del Fresno C, Crainiciuc G, Cuartero MI, Casanova-Acebes M, Weiss LA, Huerga-Encabo H, Silvestre-Roig C, Rossaint J, Cossío I, Lechuga-Vieco AV, García-Prieto J, Gómez-Parrizas M, Quintana JA, Ballesteros I, Martin-Salamanca S, Aroca-Crevillen A, Chong SZ, Evrard M, Balabanian K, López J, Bidzhekov K, Bachelerie F, Abad-Santos F, Muñoz-Calleja C, Zarbock A, Soehnlein O, Weber C, Ng LG, Lopez-Rodriguez C, Sancho D, Moro MA, Ibáñez B, Hidalgo A.

Immunity. 2019 Feb 19;50(2):390-402.e10. doi: 10.1016/j.immuni.2019.01.002.Erratum in: Immunity. 2019 Nov 19;51(5):966-967. PubMed PMID: 30709741.

• 2018

 

AhR Deletion Promotes Aberrant Morphogenesis and Synaptic Activity of Adult-Generated Granule Neurons and Impairs Hippocampus-Dependent Memory

de la Parra J, Cuartero MI, Pérez-Ruiz A, García-Culebras A, Martín R, Sánchez-Prieto J, García-Segura JM, Lizasoain I, Moro MA.

eNeuro. 2018 Aug 22;5(4). doi: 10.1523/ENEURO.0370-17.2018. PubMed PMID: 30225360; PubMed Central PMCID: PMC6140122.

 

Myeloid cells as therapeutic targets in neuroinflammation after stroke: Specific roles of neutrophils and neutrophil-platelet interactions

García-Culebras A, Durán-Laforet V, Peña-Martínez C, Ballesteros I, Pradillo JM, Díaz-Guzmán J, Lizasoain I, Moro MA.

J Cereb Blood Flow Metab. 2018 Dec;38(12):2150-2164. doi: 10.1177/0271678X18795789. PubMed PMID: 30129391.

 

Iron Overload Exacerbates the Risk of Hemorrhagic Transformation After tPA (Tissue-Type Plasminogen Activator) Administration in Thromboembolic Stroke Mice

García-Yébenes I, García-Culebras A, Peña-Martínez C, Fernández-López D, Díaz-Guzmán J, Negredo P, Avendaño C, Castellanos M, Gasull T, Dávalos A, Moro MA, Lizasoain I.

Stroke. 2018 Sep;49(9):2163-2172. doi: 10.1161/STROKEAHA.118.021540. PubMed PMID: 30018160.

 

TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models

Fernández G, Moraga A, Cuartero MI, García-Culebras A, Peña-Martínez C, Pradillo JM, Hernández-Jiménez M, Sacristán S, Ayuso MI, Gonzalo-Gobernado R, Fernández-López D, Martín ME, Moro MA, González VM, Lizasoain I.

Mol Ther. 2018 Aug 1;26(8):2047-2059. doi: 10.1016/j.ymthe.2018.05.019. PubMed PMID: 29910175.

 

Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa

Sánchez-Cruz A, Villarejo-Zori B, Marchena M, Zaldivar-Díez J, Palomo V, Gil  C, Lizasoain I, de la Villa P, Martínez A, de la Rosa EJ, Hernández-Sánchez C.

Mol Neurodegener. 2018 Apr 16;13(1):19. doi: 10.1186/s13024-018-0251-y. PubMed PMID: 29661219.

 

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

DeGregorio-Rocasolano N, Martí-Sistac O, Ponce J, Castelló-Ruiz M, Millán M, Guirao V, García-Yébenes I, Salom JB, Ramos-Cabrer P, Alborch E, Lizasoain I, Castillo J, Dávalos A, Gasull T.

Redox Biol. 2018 May;15:143-158. doi: 10.1016/j.redox.2017.11.026. PubMed PMID: 29248829.