MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology After Status Epilepticus

Edward H. Beamer, Jerónimo Jurado-Arjona, Eva M. Jiménez-Mateos, James Morgan, Cristina R. Reschke, Aidan Kenny, Gioacchino de Leo, Luis A. Olivos-Oré, Marina Arribas-Blázquez, Stephen F. Madden, Jesús Merchán-Rubira, Norman Delanty, Michael A. Farrell, Donncha F. O’Brien, Jesús Ávila , Miguel Díaz-Hernández, M. Teresa Miras-Portugal8, Antonio R. Artalejo, Félix Hernández, David C. Henshall y Tobias Engel.

FRONTIERS in Molecular Neuroscience 2018 Dec 11;11:442

Increased Ap4A levels and ecto-nucleotidase activity in glaucomatous mice retina

María J. Pérez de Lara, Ana Guzmán-Aranguez, Rosa Gómez-Villafuertes, Javier Gualix,  María Teresa Miras-Portugal y Jesús Pintor.

Purinergic Signalling 2018 14:259–270

P2X7 Nucleotide and EGF Receptors Exert Dual Modulation of the Dual-Specificity Phosphatase 6 (MKP-3) in Granule Neurons and Astrocytes, Contributing to Negative Feedback on ERK Signaling

Mª José Queipo, Juan C. Gil-Redondo, Verónica Morente, Felipe Ortega, Mª Teresa Miras-Portugal, Esmerilda G. Delicado y Raquel Pérez-Sen.

FRONTIERS in Molecular Neuroscience 2018 Jan 10;10:448

EFFECT OF THE B-AMYLOID PEPTIDE ON MICROGLIA ACTIVATION: ATP RELEASE

EFECTO DEL PÉPTIDO B-AMILOIDE EN LA ACTIVACIÓN DE LA MICROGLÍA: LIBERACIÓN DE ATP

LEMA: Microglía

Aida Menéndez Méndez, Juan Ignacio Díaz Hernández, Felipe Ortega, Rosa Gómez  Villafuertes y Javier Gualix.

Dialnet Plus 2018

Phosphodiesterase type 4 inhibition enhances nitric oxide- and hydrogen sulfidemediated bladder neck inhibitory neurotransmission

Ángel Agis-Torres, Paz Recio, Mª Elvira López-Oliva, Mª Pilar Martínez, María Victoria Barahona, Sara Benedito, Salvador Bustamante, Miguel Ángel Jiménez-Cidre, Albino García-Sacristán, Dolores Prieto, Vítor S. Fernandes y Medardo Hernández.

Scientific Reports 2018 16;8(1):4711

Alpha2-adrenoceptors in adrenomedullary chromaffin cells: functional role and pathophysiological implications

Antonio R. Artalejo y Luis Alcides Olivos-Oré.

Pflugers Arch - Eur J Physiol 2018 470:61–66

Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens

Pablo Giménez-Gómez, Mercedes Pérez-Hernández, María Dolores Gutiérrez-López , Rebeca Vidal, Cristina Abuin-Martínez, Esther O'Shea y María Isabel Colado.

Elsevier Neuropharmacology 135 2018 581-591

Young alcohol binge drinkers have elevated blood endotoxin, peripheral inflammation and low cortisol levels: neuropsychological correlations in women

Laura Orio, María Antón, Inmaculada Concepción Rodríguez-Rojo, Ángeles Correas, Borja García Bueno, Monserrat Corral, Fernando Rodríguez de Fonseca, Luis Miguel García-Moreno, Fernando Maestú y Fernando Cadaveira.

Adicttion Biology  Society for the Study of Addiction 2018 Sep;23(5):1130-1144

Regulation of inflammatory pathways in schizophrenia: A comparative study with bipolar disorder and healthy controls

L.García Álvarez, J.R. Caso, M.P. García-Portilla, L. de la Fuente-Tomás, L. González Blanco, P. Sáiz Martínez, J.C. Leza, J. Bobes.

European Psychiatry 47 January 2018 50–59 

Cardiovascular Risk in Early Psychosis: Relationship with Inflammation and Clinical Features 6 Months after Diagnosis

Maria Fe Barcones, Karina Soledad MacDowell, Borja Garcia-Bueno, Miquel Bioque, Leticia Gutiérrez Galve, Ana González-Pinto, Maria Jose Parellada, Julio Bobes, Miguel Bernardo, Antonio Lobo y Juan Carlos Leza.

International Journal of Neuropsychopharmacology 2018  21(5): 410–422

CCL2 Induces the Production of β2 Adrenergic Receptors and Modifies Astrocytic Responses to Noradrenaline

Irene L. Gutiérrez, Marta González Prieto, Borja García Bueno, Javier R. Caso, Douglas L. Feinstein y José L. M. Madrigal.

Molecular Neurobiology 2018  55:7872–7885

The effect of excess weight on circulating inflammatory cytokines in drug-naïve firstepisode psychosis individuals

María Juncal Ruíz, Laura Riesco Dávila, Víctor Ortiz García de la Foz, Mariluz Ramírez Bonilla, Obdulia Martínez García, Juan Irure Ventura, Juan Carlos Leza, Marcos López Hoyos y Benedicto Crespo Facorro.

Journal of Neuroinflammation 2018  28;15(1):63

Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis

Sergey Kalinin, Marta González-Prieto, Hannah Scheiblich, Lucia Lisi, Handojo Kusumo, Michael T. Heneka, Jose L. M. Madrigal, Subhash C. Pandey y Douglas L. Feinstein.

Kalinin et al. Journal of Neuroinflammation  2018  15:141

Comparison of the anti-inflammatory effect of aripiprazole and risperidone in 75 drug-naïve first episode psychosis individuals: A 3 months randomized study

María Juncal Ruíz, Laura Riesco Dávila, Víctor Ortiz-García de la Foz, Obdulia Martínez García, Mariluz Ramírez Bonilla, Javier Gonzalo Ocejo Viñals, Juan Carlos Leza, Marcos López Hoyos, Benedicto Crespo Facorro.

Schizophrenia Research 202  2018  226–233

Alternative Method to Detect Neuronal Degeneration and Amyloid b Accumulation in Free-Floating Brain Sections With Fluoro-Jade

Irene L. Gutiérrez, Marta González Prieto,Borja García Bueno, Javier R. Caso, Juan C. Leza y José L. M. Madrigal.

ASN Neuro Methods, American Society for Neurochemistry Volume 10: 1–7 2018

Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants

David Martín Hernández, Javier R. Caso, J. Javier Meana, Luis F. Callado, José L. M. Madrigal, Borja García Bueno y Juan C. Leza.

Journal of Neuroinflammation 2018  15:251

ALCOHOL BINGE DISRUPTS THE RAT INTESTINAL BARRIER: THE PARTIAL PROTECTIVE ROLE OF OLEOYLETHANOLAMIDE

L. Antón, A. Rodríguez-González, A. Ballesta, N. González, del Pozo, F. R. de Fonseca, Gómez-Lus, J. C. Leza, García-Bueno, Caso JR y L. Orio.

Br J Pharmacol 2018 175(24):4464-4479

Early versus late stage schizophrenia. What markers make the difference?

L. García Álvarez, M. P. García Portilla, J. R. Caso, L. de la Fuente Tomás, L. González-Blanco, P. Sáiz Martínez, J. C. Leza y J. Bobes.

The World Journal of Biological Psychiatry 2019 Feb;20(2):159-165

Repeated Restraint Stress Decreases Na,K-ATPase Activity via Oxidative and Nitrosative Damage in the Frontal Cortex of Rats

Leonardo Santana Novaes, Nilton Barreto dos Santos, Guilherme Dragunas, Juliano Genaro Perfetto, Juan Carlos Leza, Cristoforo Scavone y Carolina Demarchi Munhoz.

Neuroscience 393 (2018) 273–283

Analysis of endocannabinoid receptors and enzymes in the post-mortem motor cortex and spinal cord of amyotrophic lateral sclerosis patients

Francisco Espejo Porras, Javier Fernández Ruiz y Eva de Lago.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration  2018  (5-6):377-386

VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways

Carmen del Rio, Irene Cantarero, Belén Palomares, María Gómez Cañas, Javier Fernández-Ruiz, Carolina Pavicic, Adela García Martín, Maria Luz Bellido, Rafaela Ortega Castro, Carlos Pérez Sánchez, Chary López Pedrera, Giovanni Appendino, Marco A. Calzado y Eduardo Múñoz.

British Journal of Pharmacology 2018 175 3813-3831

The biomedical challenge of neurodegenerative disorders: an opportunity for cannabinoid-based therapies to improve on the poor current therapeutic outcomes

Javier Fernández‐Ruiz.

British Journal of Pharmacology 2018 176(10):1370-1383

Targeting glial cannabinoid CB2 receptors to delay the progression of the pathological phenotype in TDP-43 (A315T) transgenic mice, a model of amyotrophic lateral sclerosis

Francisco Espejo Porras, Laura García Toscano, Carmen Rodríguez Cueto, Irene Santos García, Eva de Lago y Javier Fernández-Ruiz.

British Journal of Pharmacology  2018  176(10):1585-1600

Novel sulfenamides and sulfonamides based on pyridazinone and pyridazine scaffolds as CB1 receptor ligand antagonists

Gabriele Murineddu, Francesco Deligia, Giulio Ragusa, Laura García Toscano, María Gómez Cañas, Battistina Asproni, Valentina Satta, Elena Cichero, Ruth Pazos, Paola Fossa, Giovanni Loriga, Javier Fernández Ruiz, Gerard A. Pinna.

Bioorganic & Medicinal Chemistry 26   2018   1;26(1):295–307

Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system

Maria S. Aymerich, Ester Aso, Miguel A. Abellanas, Rosa M. Tolon, Jose A. Ramos, Isidre Ferrer, Julian Romero, Javier Fernández-Ruiz.

Biochemical Pharmacology 157  2018  157:67-84

Neuroprotective effects of the cannabigerol quinone derivative VCE-003.2 in SOD1G93A transgenic mice, an experimental model of amyotrophic lateral sclerosis

Carmen Rodríguez Cueto, Irene Santos García, Laura García Toscano, Francisco Espejo Porras, M. Luz Bellido, Javier Fernández Ruíz, Eduardo Múñoz y Eva de Lago.

Biochemical Pharmacology    2018 157:217-226

Cannabinoid signalling in the immature brain: Encephalopathies and neurodevelopmental disorders

Onintza Sagredo, Javier Palazuelos, Ana Gutierrez Rodríguez, Valentina Satta, Ismael Galve-Roperh, José Martínez-Orgado.

Biochemical Pharmacology   2018 157:85-96

Benefits of VCE-003.2, a cannabigerol quinone derivative, against inflammationdriven neuronal deterioration in experimental Parkinson’s disease: possible involvement of different binding sites at the PPARγ receptor

Concepción García, María Gómez-Cañas, Sonia Burgaz, Belén Palomares, Yolanda Gómez-Gálvez, Cristina Palomo-Garo, Sara Campo, Joel Ferrer-Hernández, Carolina Pavicic, Carmen Navarrete, M. Luz Bellido, Moisés García-Arencibia, M. Ruth Pazos, Eduardo Muñoz y Javier Fernández Ruiz.

Journal of Neuroinflammation 2018  16;15(1):19

AhR Deletion Promotes Aberrant Morphogenesis and Synaptic Activity of Adult-Generated Granule Neurons and Impairs Hippocampus-Dependent Memory

Juan de la Parra, María I. Cuartero, Alberto Pérez Ruiz, Alicia García Culebras, Ricardo Martín, José Sánchez Prieto, Juan M. García Segura, Ignacio Lizasoain y María A. Moro

Eneuro Cognition and Behavior .0370-17  2018

Multi‐modal imaging of long‐term recovery post‐stroke by positron emission tomography and matrix‐assisted laser desorption/ionisation mass spectrometry

Fiona Henderson, Philippa J. Hart, Jesús M. Pradillo, Michael Kassiou, Lidan Christie, Kaye J. Williams, Herve Boutin y Adam McMahon.

Wiley   Rapid Communications in Mass Spectometry   2018 32(9):721-729

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage

Nuria de Gregorio-Rocasolano, Octavi Martí-Sistac, Jovita Ponce, María Castelló-Ruiz, Mónica Millán, Verónica Guirao, Isaac García-Yébenes, Juan B. Salom, Pedro Ramos-Cabrer,  Enrique Alborch, Ignacio Lizasoain, José Castillo, Antonio Dávalos y Teresa Gasulla.

Redox Biology 15  2018  143-158

Modulation of GSK-3 provides celular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa

Alonso Sánchez Cruz, Beatriz Villarejo-Zori, Miguel Marchena, Josefa Zaldivar Díez, Valle Palomo, Carmen Gil, Ignacio Lizasoain, Pedro de la Villa, Ana Martínez, Enrique J. de la Rosa y Catalina Hernández Sánchez.

Molecular Neurodegeneration  2018 Apr 16;13(1):19

Myeloid cells as therapeutic targets in neuroinflammation after stroke: Specific roles of neutrophils and neutrophil–platelet interactions

Alicia García Culebras, Violeta Durán Laforet, Carolina Peña Martínez, Iván Ballesteros, Jesús M Pradillo, Jaime Díaz Guzmán, Ignacio Lizasoain y María A Moro.

Journal of Cerebral Blood Flow & Metabolism 2018  1–15  2150-2164

Recovery of ‘‘Lost’’ Infant Memories in Mice

Axel Guskjolen, Justin W. Kenney, Juan de la Parra, Bi-ru Amy Yeung, Sheena A. Josselyn y Paul W. Frankland.

Curr Biol 2018 Jul  28(14):2283-2290

Iron Overload Exacerbates the Risk of Hemorrhagic Transformation After tPA (Tissue-Type Plasminogen Activator) Administration in Thromboembolic Stroke Mice

Isaac García-Yébenes, Alicia García-Culebras, Carolina Peña-Martínez, David Fernández-López, Jaime Díaz-Guzmán, Pilar Negredo, Carlos Avendaño, Mar Castellanos, Teresa Gasull, Antoni Dávalos, María A. Moro e Ignacio Lizasoain.

Stroke  2018 Sep;49(9):2163-2172

TLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models

Gerónimo Fernández, Ana Moraga, María I. Cuartero, Alicia García-Culebras, Carolina Peña Martínez, Jesús M. Pradillo, Macarena Hernández-Jiménez, Silvia Sacristán, M. Irene Ayuso, Rafael Gonzalo Gobernado, David Fernández López, M. Elena Martín, María A. Moro, Victor M. González e Ignacio Lizasoain.

Molecular Therapy 2018 49(9):2163-2172

Deregulation of the endocannabinoid system and therapeutic potential of ABHD6 blockade in the cuprizone model of demyelination

Andrea Manterola, Ana Bernal-Chico, Raffaela Cipriani, Manuel Canedo-Antelo, Álvaro Moreno García, Mar Martín-Fontecha, Fernando Pérez-Cerdá, María Victoria Sánchez Gómez, Silvia Ortega Gutiérrez, J. Mark Brown, Ku-Lung Hsu, Benjamin Cravatt, Carlos Matute y Susana Mato.

Biochemical Pharmacology 157  2018  189-201

Monoacylglycerol lipase (MAGL) as a promising therapeutic target

Ana Gil-Ordóñez, Mar Martín-Fontecha, Silvia Ortega Gutiérrez y María L. López Rodríguez.

Biochemical Pharmacology   2018  157 18-32

Development of a Fluorescent Bodipy Probe for Visualization of the Serotonin 5‑HT1A Receptor in Native Cells of the Immune System

Gloria Hernández Torres, Ernesto Enríquez Palacios, Miriam Mecha, Ana Feliú, Ainoa Rueda Zubiaurre, Alba Angelina, Leticia Martín Cruz, Mar Martín Fontecha, Oscar Palomares, Carmen Guaza, Eduardo Peña Cabrera, María L. López Rodríguez y Silvia Ortega-Gutiérrez.

Bioconjugate Chem. 2018 29, 2021−2027

A Fluorescent Probe to Unravel Functional Features of Cannabinoid Receptor CB1 in Human Blood and Tonsil Immune System Cells

Mar Martín Fontecha, Alba Angelina, Beate Rückert, Ainoa Rueda Zubiaurre, Leticia Martín Cruz, Willem van de Veen, Mübeccel Akdis, Silvia Ortega Gutiérrez, María Luz López Rodríguez, Cezmi A. Akdis y Oscar Palomares.

Bioconjugate Chem. 2018, 29,2 382−389

2-AG limits Theiler’s virus induced acute neuroinflammation by modulating microglia and promoting MDSCs

Miriam Mecha, Ana Feliu, Isabel Machín, César Cordero, Francisco Carrillo Salinas, Leyre Mestre, Gloria Hernández-Torres, Silvia Ortega-Gutiérrez, María L López Rodríguez, Fernando de Castro, Diego Clemente y Carmen Guaza.

Glia  2018  66(7):1447-146 2018

Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes

Federico Camicia, Ana M. Celentano, Malcolm E. Johns, John D. Chan, Lucas Maldonado, Hugo Vaca, Nicolás Di Siervi, Laura Kamentezky, Ana M. Gamo, Silvia Ortega-Gutierrez, Mar Martin-Fontecha, Carlos Davio, Jonathan S. Marchant y

Mara C. Rosenzvit.

NEGLECTED TROPICAL DISEASES  2018  12(2):e0006267

Appraising the “entourage effect”: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer

Sandra Blasco Benito, Marta Seijo Vila, Miriam Caro Villalobos, Isabel Tundidor, Clara Andradas, Elena García Taboada, Jeff Wade, Stewart Smith, Manuel Guzmán, Eduardo Pérez Gómez, Mara Gordon y Cristina Sánchez.

Biochemical Pharmacology    2018   157 285-293

Cannabis for the Management of Cancer Symptoms: THC Version 2.0?

Manuel Guzmán.

Cannabis and Cannabinoid Research Volume 3.1, 2018

Targeting Glioma Initiating Cells with A combined therapy of cannabinoids and temozolomide

Israel López Valero, Cristina Saiz Ladera, Sofía Torres, Sonia Hernández Tiedra, Elena García Taboada, Fátima Rodríguez Fornés, Marina Barba, David Dávila, Nélida Salvador Tormo, Manuel Guzmán, Juan M. Sepúlveda, Pilar Sánchez Gómez,

Mar Lorente y Guillermo Velasco.

Biochemical Pharmacology  2018  157 266-274

Optimization of a preclinical therapy of cannabinoids in combination with temozolomide against glioma

Israel López Valero, Sofía Torres, María Salazar Roa, Elena García Taboada, Sonia Hernández Tiedra, Manuel Guzmán, Juan M. Sepúlveda, Guillermo Velasco, Mar Lorente.

Biochemical Pharmacology  2018  157 275-284

Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum

Estefanía Moreno, Anna Chiarlone, Mireia Medrano, Mar Puigdellívol, Lucka Bibic, Lesley A Howell, Eva Resel, Nagore Puente, María J Casarejos, Juan Perucho, Joaquín Botta, Nuria Suelves, Francisco Ciruela, Silvia Ginés, Ismael Galve-Roperh, Vicent Casadó, Pedro Grandes, Beat Lutz, Krisztina Monory, Enric I Canela, Carmen Lluís, Peter J McCormick y Manuel Guzmán.

Neuropsychopharmacology  2018   43, 964–977

Cognition and Behavior AhR Deletion Promotes Aberrant Morphogenesis and Synaptic Activity of Adult-Generated Granule Neurons and Impairs Hippocampus Dependent Memory

Juan de la Parra, María I. Cuartero, Alberto Pérez Ruiz, Alicia García Culebras, Ricardo Martín, José Sánchez Prieto, Juan M. García Segura, Ignacio Lizasoain y María A. Moro.

Eneuro cognition and behavior ENEURO.0370-17.2018

Bidirectional modulation of glutamatergic synaptic transmission by metabotropic glutamate type 7 receptors at Schaffer collateral–CA1 hippocampal synapses

Ricardo Martín, José Javier Ferrero, Andrea Collado-Alsina, Carolina Aguado, Rafael Luján, Magdalena Torres y José Sánchez-Prieto.

J Physiol 596.5 2018 pp 921–940

Pathway-Specific Control of Striatal Neuron Vulnerability by Corticostriatal Cannabinoid CB1 Receptors

Andrea Ruiz Calvo, Irene B. Maroto, Raquel Bajo Grañeras, Anna Chiarlone, Ángel Gaudioso, José J. Ferrero, Eva Resel, José Sánchez Prieto, José A. Rodríguez Navarro, Giovanni Marsicano, Ismael Galve-Roperh, Luigi Bellocchio y Manuel Guzmán.

Cerebral Cortex, 2018 28(1):307-322