Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice.

Olivencia MA, de Biedma-Elduayen LG, Giménez-Gómez P, Barreira B, Fernández A, Angulo J, Colado MI, O'Shea E, Perez-Vizcaino F.

Br J Pharmacol. 2023 Apr 6. doi: 10.1111/bph.16087. Online ahead of print.PMID: 37021655

 

Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice.

Gil de Biedma-Elduayen L, Giménez-Gómez P, Morales-Puerto N, Vidal R, Núñez-de la Calle C, Gutiérrez-López MD, O'Shea E, Colado MI.

Br J Pharmacol. 2022 Jul;179(14):3711-3726. doi: 10.1111/bph.15825. Epub 2022 Mar 7.PMID: 35189673 Free PMC article.

 

Decreased kynurenine pathway potentiate resilience to social defeat effect on cocaine reward.

Giménez-Gómez P, Ballestín R, Gil de Biedma-Elduayen L, Vidal R, Ferrer-Pérez C, Reguilón MD, O'Shea E, Miñarro J, Colado MI, Rodríguez-Arias M.

Neuropharmacology. 2021 Oct 1;197:108753. doi: 10.1016/j.neuropharm.2021.108753. Epub 2021 Aug 11.PMID: 34389399 Free article.

  

Addiction and the kynurenine pathway: A new dancing couple?

Morales-Puerto N, Giménez-Gómez P, Pérez-Hernández M, Abuin-Martínez C, Gil de Biedma-Elduayen L, Vidal R, Gutiérrez-López MD, O'Shea E, Colado MI.

Pharmacol Ther. 2021 Jul;223:107807. doi: 10.1016/j.pharmthera.2021.107807. Epub 2021 Jan 19.PMID: 33476641 Review.

 

Plasma tryptophan and kynurenine pathway metabolites in abstinent patients with alcohol use disorder and high prevalence of psychiatric comorbidity.

Vidal R, García-Marchena N, O'Shea E, Requena-Ocaña N, Flores-López M, Araos P, Serrano A, Suárez J, Rubio G, Rodríguez de Fonseca F, Colado MI, Pavón FJ.

Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 30;102:109958. doi: 10.1016/j.pnpbp.2020.109958. Epub 2020 Apr 29.PMID: 32360814

 

Serotonin is the main tryptophan metabolite associated with psychiatric comorbidity in abstinent cocaine-addicted patients.

Araos P, Vidal R, O'Shea E, Pedraz M, García-Marchena N, Serrano A, Suárez J, Castilla-Ortega E, Ruiz JJ, Campos-Cloute R, Santín LJ, Rodríguez de Fonseca F, Pavón FJ, Colado MI.

Sci Rep. 2019 Nov 14;9(1):16842. doi: 10.1038/s41598-019-53312-0.PMID: 31727978 Free PMC article.

 

Changes in brain kynurenine levels via gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice.

Giménez-Gómez P, Pérez-Hernández M, O'Shea E, Caso JR, Martín-Hernandez D, Cervera LA, Centelles MLG, Gutiérrez-Lopez MD, Colado MI.

FASEB J. 2019 Nov;33(11):12900-12914. doi: 10.1096/fj.201900491RR. Epub 2019 Sep 11.PMID: 31509716 Free PMC article.

 

Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens.

Giménez-Gómez P, Pérez-Hernández M, Gutiérrez-López MD, Vidal R, Abuin-Martínez C, O'Shea E, Colado MI.

Neuropharmacology. 2018 Jun;135:581-591. doi: 10.1016/j.neuropharm.2018.04.016. Epub 2018 Apr 18.PMID: 29705534

 

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA₁ Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity.

Peñalver A, Campos-Sandoval JA, Blanco E, Cardona C, Castilla L, Martín-Rufián M, Estivill-Torrús G, Sánchez-Varo R, Alonso FJ, Pérez-Hernández M, Colado MI, Gutiérrez A, de Fonseca FR, Márquez J.

Front Mol Neurosci. 2017 Sep 5;10:278. doi: 10.3389/fnmol.2017.00278. eCollection 2017.PMID: 28928633 Free PMC article.

 

3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) produces edema due to BBB disruption induced by MMP-9 activation in rat hippocampus.

Pérez-Hernández M, Fernández-Valle ME, Rubio-Araiz A, Vidal R, Gutiérrez-López MD, O'Shea E, Colado MI.

Neuropharmacology. 2017 May 15;118:157-166. doi: 10.1016/j.neuropharm.2017.03.019. Epub 2017 Mar 16.PMID: 28322979

 

Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model.

Rubio-Araiz A, Porcu F, Pérez-Hernández M, García-Gutiérrez MS, Aracil-Fernández MA, Gutierrez-López MD, Guerri C, Manzanares J, O'Shea E, Colado MI.

Addict Biol. 2017 Jul;22(4):1103-1116. doi: 10.1111/adb.12376. Epub 2016 Mar 7.PMID: 26949123

 

Effects of repeated social defeat on adolescent mice on cocaine-induced CPP and self-administration in adulthood: integrity of the blood-brain barrier.

Rodríguez-Arias M, Montagud-Romero S, Rubio-Araiz A, Aguilar MA, Martín-García E, Cabrera R, Maldonado R, Porcu F, Colado MI, Miñarro J.

Addict Biol. 2017 Jan;22(1):129-141. doi: 10.1111/adb.12301. Epub 2015 Sep 16.PMID: 26374627

 

3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier integrity through a mechanism involving P2X7 receptors.

Rubio-Araiz A, Perez-Hernandez M, Urrutia A, Porcu F, Borcel E, Gutierrez-Lopez MD, O'Shea E, Colado MI.

Int J Neuropsychopharmacol. 2014 Aug;17(8):1243-55. doi: 10.1017/S1461145714000145. Epub 2014 Mar 14.PMID: 24626059 Free article.

 

Current preclinical studies on neuroinflammation and changes in blood-brain barrier integrity by MDMA and methamphetamine.

O'Shea E, Urrutia A, Green AR, Colado MI.

Neuropharmacology. 2014 Dec;87:125-34. doi: 10.1016/j.neuropharm.2014.02.015. Epub 2014 Mar 2.PMID: 24594477 Review.

 

The JNK inhibitor, SP600125, potentiates the glial response and cell death induced by methamphetamine in the mouse striatum.

Urrutia A, Granado N, Gutierrez-Lopez MD, Moratalla R, O'Shea E, Colado MI.

Int J Neuropsychopharmacol. 2014 Feb;17(2):235-46. doi: 10.1017/S1461145713000850. Epub 2013 Oct 8.PMID: 24103647 Free article.

 

Cocaine potentiates MDMA-induced oxidative stress but not dopaminergic neurotoxicity in mice: implications for the pathogenesis of free radical-induced neurodegenerative disorders.

Peraile I, Granado N, Torres E, Gutiérrez-López MD, Moratalla R, Colado MI, O'Shea E.

Psychopharmacology (Berl). 2013 Nov;230(1):125-35. doi: 10.1007/s00213-013-3142-5. Epub 2013 May 17.PMID: 23681166

 

A study on the effect of JNK inhibitor, SP600125, on the disruption of blood-brain barrier induced by methamphetamine.

Urrutia A, Rubio-Araiz A, Gutierrez-Lopez MD, ElAli A, Hermann DM, O'Shea E, Colado MI.

Neurobiol Dis. 2013 Feb;50:49-58. doi: 10.1016/j.nbd.2012.10.006. Epub 2012 Oct 12.PMID: 23069681

 

Apolipoprotein-E controls adenosine triphosphate-binding cassette transporters ABCB1 and ABCC1 on cerebral microvessels after methamphetamine intoxication.

ElAli A, Urrutia A, Rubio-Araiz A, Hernandez-Jimenez M, Colado MI, Doeppner TR, Hermann DM.

Stroke. 2012 Jun;43(6):1647-53. doi: 10.1161/STROKEAHA.111.648923. Epub 2012 Mar 15.PMID: 22426312

 

Changes in the serotonergic system and in brain-derived neurotrophic factor distribution in the main olfactory bulb of pcd mice before and after mitral cell loss.

Gómez C, Curto GG, Baltanás FC, Valero J, O'Shea E, Colado MI, Díaz D, Weruaga E, Alonso JR.

Neuroscience. 2012 Jan 10;201:20-33. doi: 10.1016/j.neuroscience.2011.11.025. Epub 2011 Nov 20.PMID: 22133893

 

Dopamine D(1) receptor deletion strongly reduces neurotoxic effects of methamphetamine.

Ares-Santos S, Granado N, Oliva I, O'Shea E, Martin ED, Colado MI, Moratalla R.

Neurobiol Dis. 2012 Feb;45(2):810-20. doi: 10.1016/j.nbd.2011.11.005. Epub 2011 Nov 13.PMID: 22115942

 

Increased interleukin-1β levels following low dose MDMA induces tolerance against the 5-HT neurotoxicity produced by challenge MDMA.

Mayado A, Torres E, Gutierrez-Lopez MD, Colado MI, O'Shea E.

J Neuroinflammation. 2011 Nov 24;8:165. doi: 10.1186/1742-2094-8-165.PMID: 22114930 Free PMC article.

 

Changes in interleukin-1 signal modulators induced by 3,4-methylenedioxymethamphetamine (MDMA): regulation by CB2 receptors and implications for neurotoxicity.

Torres E, Gutierrez-Lopez MD, Mayado A, Rubio A, O'Shea E, Colado MI.

J Neuroinflammation. 2011 May 19;8:53. doi: 10.1186/1742-2094-8-53.PMID: 21595923 Free PMC article.

 

Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA.

Granado N, Ares-Santos S, Oliva I, O'Shea E, Martin ED, Colado MI, Moratalla R.

Neurobiol Dis. 2011 Jun;42(3):391-403. doi: 10.1016/j.nbd.2011.01.033. Epub 2011 Feb 15.PMID: 21303698

 

Involvement of 2-arachidonoyl glycerol in the increased consumption of and preference for ethanol of mice treated with neurotoxic doses of methamphetamine.

Gutierrez-Lopez MD, Llopis N, Feng S, Barrett DA, O'Shea E, Colado MI.

Br J Pharmacol. 2010 Jun;160(3):772-83. doi: 10.1111/j.1476-5381.2010.00720.x.PMID: 20590579 Free PMC article.

 

Sex-dependent maternal deprivation effects on brain monoamine content in adolescent rats.

Llorente R, O'Shea E, Gutierrez-Lopez MD, Llorente-Berzal A, Colado MI, Viveros MP.

Neurosci Lett. 2010 Jul 26;479(2):112-7. doi: 10.1016/j.neulet.2010.05.039. Epub 2010 May 20.PMID: 20493239

 

Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain.

Torres E, Gutierrez-Lopez MD, Borcel E, Peraile I, Mayado A, O'Shea E, Colado MI.

J Neurochem. 2010 Apr;113(1):67-78. doi: 10.1111/j.1471-4159.2010.06578.x. Epub 2010 Jan 12.PMID: 20067581 Free article.

 

Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice.

Peraile I, Torres E, Mayado A, Izco M, Lopez-Jimenez A, Lopez-Moreno JA, Colado MI, O'Shea E.

Br J Pharmacol. 2010 Jan;159(1):201-11. doi: 10.1111/j.1476-5381.2009.00522.x. Epub 2009 Dec 10.PMID: 20015297 Free PMC article.