Publicaciones científicas

 

• Publicaciones de los últimos 5 años:

 

Inflammatory and Antioxidant Pathway Dysfunction in Borderline Personality Disorder. 
Karina S MacDowell, Marina Díaz Marsá, Eva Buenache, Jose M López Villatoro, Beatriz Moreno, Juan C Leza, José L Carrasco.
Psychiatry Res. 2020 Feb (284) 112782. doi: 10.1016/j.psychres.2020.112782

Toll-like Receptor 4 Agonist and Antagonist Lipopolysaccharides Modify Innate Immune Response in Rat Brain Circumventricular Organs
Alejandra Vargas-Caraveo, Aline Sayd, Javier Robledo-Montaña, Javier R Caso, José L M Madrigal, Borja García-Bueno, Juan C Leza
J Neuroinflammation. 2020 Jan; 17(1), 6. doi: 10.1186/s12974-019-1690-2

Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats With Neonatal Ventral Hippocampus Lesion.
Hiram Tendilla-Beltrán, Silvia Meneses-Prado, Rubén Antonio Vázquez-Roque, Miguel Tapia-Rodríguez, Andrea Judith Vázquez-Hernández, Heriberto Coatl-Cuaya, David Martín-Hernández, Karina S MacDowell, Linda Garcés-Ramírez, Juan C Leza, Gonzalo Flores 
J Neurosci. 2019 Oct; 39 (43) 8584-8599. doi: 10.1523/JNEUROSCI.1249-19.2019

CCL2 Induces the Production of β2 Adrenergic Receptors and Modifies Astrocytic Responses to Noradrenaline.
Gutiérrez IL, González-Prieto M, García-Bueno B, Caso JR, Feinstein DL, Madrigal JLM.
Mol Neurobiol. 2018 Oct;55(10):7872-7885. doi: 10.1007/s12035-018-0960-9.

Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.
Kalinin S, González-Prieto M, Scheiblich H, Lisi L, Kusumo H, Heneka MT, Madrigal JLM, Pandey SC, Feinstein DL.
J Neuroinflammation. 2018 May 14;15(1):141. doi: 10.1186/s12974-018-1184-7.

CIBERSAM: Ten years of collaborative translational research in mental disorders.
Salagre E, Arango C, Artigas F, Ayuso-Mateos JL, Bernardo M, Castro-Fornieles J, Bobes J, Desco M, Fañanás L, González-Pinto A, Haro JM, Leza JC, Mckenna PJ, Meana JJ, Menchón JM, Micó JA, Palomo T, Pazos Á, Pérez V, Saiz-Ruiz J, Sanjuán J, Tabarés-Seisdedos R, Crespo-Facorro B, Casas M, Vilella E, Palao D, Olivares JM, Rodriguez-Jimenez R, Vieta E. 
Rev Psiquiatr Salud Ment. 2018 Nov 8. pii: S1888-9891(18)30095-8. doi: 10.1016/j.rpsm.2018.10.001.

Repeated Restraint Stress Decreases Na,K-ATPase Activity via Oxidative and Nitrosative Damage in the Frontal Cortex of Rats.
Novaes LS, Dos Santos NB, Dragunas G, Perfetto JG, Leza JC, Scavone C, Munhoz CD.
Neuroscience. 2018 Oct 12;393:273-283. doi: 10.1016/j.neuroscience.2018.09.037. 

Early versus late stage schizophrenia. What markers make the difference?
García-Álvarez L, García-Portilla MP, Caso JR, de la Fuente-Tomás L, González-Blanco L, Sáiz Martínez P, Leza JC, Bobes J.
World J Biol Psychiatry. 2018 Oct 8:1-7. doi: 10.1080/15622975.2018.1511920. 

Alcohol binge disrupts the rat intestinal barrier: the partial protective role of oleoylethanolamide. 
Antón M, Rodríguez-González A, Ballesta A, González N, Del Pozo A, de Fonseca FR, Gómez-Lus ML, Leza JC, García-Bueno B, Caso JR, Orio L.
Br J Pharmacol. 2018 Sep 24. doi: 10.1111/bph.14501. 

Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants. 
Martín-Hernández D, Caso JR, Javier Meana J, Callado LF, Madrigal JLM, García-Bueno B, Leza JC.
J Neuroinflammation. 2018 Sep 4;15(1):251. doi: 10.1186/s12974-018-1294-2.

Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-analysis. 
Fraguas D, Díaz-Caneja CM, Ayora M, Hernández-Álvarez F, Rodríguez-Quiroga A, Recio S, Leza JC, Arango C.
Schizophr Bull. 2018 Aug 28. doi: 10.1093/schbul/sby125. 

Alternative Method to Detect Neuronal Degeneration and Amyloid β Accumulation in Free-Floating Brain Sections With Fluoro-Jade. 
Gutiérrez IL, González-Prieto M, García-Bueno B, Caso JR, Leza JC, Madrigal JLM.
ASN Neuro. 2018 Jan-Dec;10:1759091418784357. doi: 10.1177/1759091418784357.

Comparison of the anti-inflammatory effect of aripiprazole and risperidone in 75 drug-naïve first episode psychosis individuals: A 3 months randomized study.
Juncal-Ruiz M, Riesco-Dávila L, Ortiz-García de la Foz V, Martínez-Garcia O, Ramírez-Bonilla M, Ocejo-Viñals JG, Leza JC, López-Hoyos M, Crespo-Facorro B. 
Schizophr Res. 2018 Jun 22. pii: S0920-9964(18)30372-4. doi: 10.1016/j.schres.2018.06.039.

Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats. 
Martín-Hernández D, Tendilla-Beltrán H, Madrigal JLM, García-Bueno B, Leza JC, Caso JR.
Mol Neurobiol. 2018 May 3. doi: 10.1007/s12035-018-1096-7.

The effect of excess weight on circulating inflammatory cytokines in drug-naïve first-episode psychosis individuals.
Juncal-Ruiz M, Riesco-Dávila L, de la Foz VO, Ramírez-Bonilla M, Martínez-García O, Irure-Ventura J, Leza JC, López-Hoyos M, Crespo-Facorro B. 
J Neuroinflammation. 2018 Feb 28;15(1):63. doi: 10.1186/s12974-018-1096-6.

Cardiovascular risk in early psychosis. Relationship with inflammation and clinical features 6 months after diagnosis.
Barcones MMF, MacDowell KS, García Bueno B, Bioque M, Gutiérrez-Galve L, González Pinto A, Parellada MJ, Bobes J, Bernardo M, Lobo A, Leza JC; FLAMM-PEPs study; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Int J Neuropsychopharmacol. 2017 Dec 8. doi: 10.1093/ijnp/pyx110.

Regulation of inflammatory pathways in schizophrenia: A comparative study with bipolar disorder and healthy controls.
García-Álvarez L, Caso JR, García-Portilla MP, de la Fuente-Tomás L, González-Blanco L, Sáiz Martínez P, Leza JC, Bobes J.
Eur Psychiatry. 2018 Jan;47:50-59. doi: 10.1016/j.eurpsy.2017.09.007. 

Lipopolysaccharide enters the rat brain by a lipoprotein-mediated transport mechanism in physiological conditions.
Vargas-Caraveo A, Sayd A, Maus SR, Caso JR, Madrigal JLM, García-Bueno B, Leza JC.
Sci Rep. 2017 Oct 13;7(1):13113. doi: 10.1038/s41598-017-13302-6.

Differential regulation of the TLR4 signalling pathway in post-mortem prefrontal cortex and cerebellum in chronic schizophrenia: Relationship with SP transcription factors.
MacDowell KS, Pinacho R, Leza JC, Costa J, Ramos B, García-Bueno B.
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt B):481-492. doi: 10.1016/j.pnpbp.2017.08.005. 

The Role of the Microbial Metabolites Including Tryptophan Catabolites and Short Chain Fatty Acids in the Pathophysiology of Immune-Inflammatory and Neuroimmune Disease. 
Morris G, Berk M, Carvalho A, Caso JR, Sanz Y, Walder K, Maes M. 
Mol Neurobiol. 2017 Aug;54(6):4432-4451. doi: 10.1007/s12035-016-0004-2. 

Young alcohol binge drinkers have elevated blood endotoxin, peripheral inflammation and low cortisol levels: neuropsychological correlations in women. 
Orio L, Antón M, Rodríguez-Rojo IC, Correas Á, García-Bueno B, Corral M, de Fonseca FR, García-Moreno LM, Maestú F, Cadaveira F. 
Addict Biol. 2017 Aug 25. doi: 10.1111/adb.12543.

Paliperidone reverts Toll-like receptor 3 signaling pathway activation and cognitive deficits in a maternal immune activation mouse model of schizophrenia.
MacDowell KS, Munarriz-Cuezva E, Caso JR, Madrigal JL, Zabala A, Meana JJ, García-Bueno B, Leza JC.
Neuropharmacology. 2017 Apr;116:196-207. doi: 10.1016/j.neuropharm.2016.12.025.

Noradrenaline induces CX3CL1 production and release by neurons.
Madrigal JL, Caso JR, García-Bueno B, Gutiérrez IL, Leza JC.
Neuropharmacology. 2017 Mar 1;114:146-155. doi: 10.1016/j.neuropharm.2016.12.001. 

The Microbiota and Gut-Brain Axis: Contributions to the Immunopathogenesis of Schizophrenia. 
Caso JR, Balanzá-Martínez V, Palomo T, García-Bueno B. 
Curr Pharm Des. 2016;22(40):6122-6133. Review.

The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome. 
Morris G, Berk M, Carvalho AF, Caso JR, Sanz Y, Maes M. 
Curr Pharm Des. 2016;22(40):6058-6075. Review.

The Atypical Antipsychotic Paliperidone Regulates Endogenous Antioxidant/Anti-Inflammatory Pathways in Rat Models of Acute and Chronic Restraint Stress.
MacDowell KS, Caso JR, Martín-Hernández D, Moreno BM, Madrigal JLM, Micó JA, Leza JC, García-Bueno B.
Neurotherapeutics. 2016 Oct;13(4):833-843. doi: 10.1007/s13311-016-0438-2.

Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia. 
García-Bueno B, Gassó P, MacDowell KS, Callado LF, Mas S, Bernardo M, Lafuente A, Meana JJ, Leza JC. 
J Psychiatry Neurosci. 2016 Apr;41(3):E46-55.

Cognition and psychopathology in first-episode psychosis: are they related to inflammation? 
Cabrera B, Bioque M, Penadés R, González-Pinto A, Parellada M, Bobes J, Lobo A, García-Bueno B, Leza JC, Bernardo M.
Psychol Med. 2016 Jul;46(10):2133-44. doi: 10.1017/S0033291716000659.

Effects of the antipsychotic paliperidone on stress-induced changes in the endocannabinoid system in rat prefrontal cortex. 
MacDowell KS, Sayd A, García-Bueno B, Caso JR, Madrigal JLM, Leza JC. 
World J Biol Psychiatry. 2017 Sep;18(6):457-470. doi: 10.3109/15622975.2016.1151075.

Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases. 
García Bueno B, Caso JR, Madrigal JL, Leza JC. 
Neurosci Biobehav Rev. 2016 May;64:134-47. doi: 10.1016/j.neubiorev.2016.02.013.

Oleoylethanolamide prevents neuroimmune HMGB1/TLR4/NF-kB danger signaling in rat frontal cortex and depressive-like behavior induced by ethanol binge administration. 
Antón M, Alén F, Gómez de Heras R, Serrano A, Pavón FJ, Leza JC, García-Bueno B, Rodríguez de Fonseca F, Orio L. 
Addict Biol. 2017 May;22(3):724-741. doi: 10.1111/adb.12365. 

Dysregulated peripheral endocannabinoid system signaling is associated with cognitive deficits in first-episode psychosis. 
Bioque M, Cabrera B, García-Bueno B, Mac-Dowell KS, Torrent C, Saiz PA, Parellada M, González-Pinto A, Lobo A, Leza JC, Bernardo M; FLAMM-PEPs Study - Centro de Investigación Biomédica en Red de Salud Mental.
J Psychiatr Res. 2016 Apr;75:14-21. doi: 10.1016/j.jpsychires.2016.01.002. 

Discrimination between Alzheimer's Disease and Late Onset Bipolar Disorder Using Multivariate Analysis. 
Besga A, Gonzalez I, Echeburua E, Savio A, Ayerdi B, Chyzhyk D, Madrigal JL, Leza JC, Graña M, Gonzalez-Pinto AM. 
Front Aging Neurosci. 2015 Dec 14;7:231. doi: 10.3389/fnagi.2015.00231.

Bacterial translocation affects intracellular neuroinflammatory pathways in a depression-like model in rats. 
Martín-Hernández D, Caso JR, Bris ÁG, Maus SR, Madrigal JL, García-Bueno B, MacDowell KS, Alou L, Gómez-Lus ML, Leza JC.
Neuropharmacology. 2016 Apr;103:122-33. doi: 10.1016/j.neuropharm.2015.12.003.

Modulation of the antioxidant nuclear factor (erythroid 2-derived)-like 2 pathway by antidepressants in rats. 
Martín-Hernández D, Bris ÁG, MacDowell KS, García-Bueno B, Madrigal JL, Leza JC, Caso JR. 
Neuropharmacology. 2016 Apr;103:79-91. doi: 10.1016/j.neuropharm.2015.11.029. 

Stress Increases the Negative Effects of Chronic Pain on Hippocampal Neurogenesis. 
Romero-Grimaldi C, Berrocoso E, Alba-Delgado C, Madrigal JL, Perez-Nievas BG, Leza JC, Mico JA. 
Anesth Analg. 2015 Oct;121(4):1078-88. doi: 10.1213/ANE.0000000000000838.

BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. 
Martinez-Cengotitabengoa M, MacDowell KS, Alberich S, Diaz FJ, Garcia-Bueno B, Rodriguez-Jimenez R, Bioque M, Berrocoso E, Parellada M, Lobo A, Saiz PA, Matute C, Bernardo M, Gonzalez-Pinto A, Leza JC; FLAMM-PEPs. 
Schizophr Bull. 2016 Jan;42(1):142-51. doi: 10.1093/schbul/sbv078.

Therapeutic antidepressant potential of a conjugated siRNA silencing the serotonin transporter after intranasal administration. 
Ferrés-Coy A, Galofré M, Pilar-Cuéllar F, Vidal R, Paz V, Ruiz-Bronchal E, Campa L, Pazos Á, Caso JR, Leza JC, Alvarado G, Montefeltro A, Valdizán EM, Artigas F, Bortolozzi A. 
Mol Psychiatry. 2016 Mar;21(3):328-38. doi: 10.1038/mp.2015.80.

Inflammation in schizophrenia: A question of balance. 
Leza JC, García-Bueno B, Bioque M, Arango C, Parellada M, Do K, O'Donnell P, Bernardo M. 
Neurosci Biobehav Rev. 2015 Aug;55:612-26. doi: 10.1016/j.neubiorev.2015.05.014.

Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: A critical review. 
Palma-Gudiel H, Córdova-Palomera A, Leza JC, Fañanás L. 
Neurosci Biobehav Rev. 2015 Aug;55:520-35. doi: 10.1016/j.neubiorev.2015.05.016.

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research. 
Maes M, Nowak G, Caso JR, Leza JC, Song C, Kubera M, Klein H, Galecki P, Noto C, Glaab E, Balling R, Berk M. 
Mol Neurobiol. 2016 Jul;53(5):2927-2935. doi: 10.1007/s12035-015-9183-5. 

Building up careers in translational neuroscience and mental health research: Education and training in the Centre for Biomedical Research in Mental Health. 
Rapado-Castro M, Pazos Á, Fañanás L, Bernardo M, Ayuso-Mateos JL, Leza JC, Berrocoso E, de Arriba J, Roldán L, Sanjuán J, Pérez V, Haro JM, Palomo T, Valdizan EM, Micó JA, Sánchez M, Arango C.
Rev Psiquiatr Salud Ment. 2015 Apr-Jun;8(2):65-74. doi: 10.1016/j.rpsm.2014.09.003.