JEFE DE GRUPO (NEUROGÉNESIS): ISMAEL GALVE ROPERH

 

 Δ9-Tetrahydrocannabinol promotes functional remyelination in the mouse brain

Aguado, T.*, Huerga-Gómez, A.*, Sánchez-de la Torre, A., Resel, E., Chara, J.C., Matute, C., Mato, S., Galve-Roperh, I., Guzmán, M., Palazuelos, J. 

British Journal of Pharmacology 2021

 

Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB₁ receptors

Paraíso-Luna, J., Aguareles, J., Martín, R., Ayo-Martín, A.C., Simón-Sánchez, S., García-Rincón, D., Costas-Insua, C., García-Taboada, E., de Salas-Quiroga, A., Díaz-Alonso, J., Liste, I., Sánchez-Prieto, J., Cappello, S., Guzmán, M., Galve-Roperh, I.

Development 2020

Δ9 -Tetrahydrocannabinol promotes oligodendrocyte development and CNS myelination in vivo. 

Huerga-Gómez, A., Aguado, T., Sánchez-de la Torre, A., Bernal-Chico, A., Matute, C., Mato, S., Guzmán, M., Galve-Roperh, I., Palazuelos, J.

Glia 2021

 

Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure

de Salas-Quiroga, A.*, García-Rincón, D.*, Gómez-Domínguez, D., Valero, M., Simón-Sánchez, S., Paraíso-Luna, J., Aguareles, J., Pujadas, M., Muguruza, C., Callado, L. F., Lutz, B., Guzmán, M., de la Prida, L. M., Galve-Roperh, I. 

Neuropsychopharmacology 2020

 

Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

Aguareles, J., Paraíso-Luna, J., Palomares, B., Bajo-Grañeras, R., Navarrete, C., Ruiz-Calvo, A., García-Rincón, D., García-Taboada, E., Guzmán, M., Muñoz, E., Galve-Roperh, I. 

Translational Neurodegeneration 2019

 

Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia

García-Rincón, D., Díaz-Alonso, J., Paraíso-Luna, J., Ortega, Z., Aguareles, J., de Salas-Quiroga, A., Jou, C., de Prada, I., Martínez-Cerdeño, V., Aronica, E., Guzmán, M., Pérez-Jiménez, M.Á., Galve-Roperh, I. 

Frontiers in Pharmacology 2019

 

Plastic mechanisms involved in the therapeutical effects of cannabidiol in psychiatric disorders.

Campos, A.C., Fogaça, M.V., Scarante, F.F., Joca, S.R., Salles, A.J., Gomes, F.V., Sonego, A.B., Rodrigues, N.S., Galve-Roperh, I., Guimarães, F.S. 

Frontiers in Pharmacology 2017

 

Cannabinoid type 2 receptor drives neurogenesis and improves functional outcome after stroke

Bravo-Ferrer, I., Cuartero, M.I., Zarruk, J.G., Pradillo, J.M., Hurtado, O., Romera, V.G., Díaz-Alonso, J., García-Segura, J.M., Guzmán, M., Lizasoain, I., Galve-Roperh, I., Moro M.A. 

Stroke 2017

 

 Loss of cannabinoid CB₁ receptors induces cortical migration malformations and increases seizure susceptibility

Díaz-Alonso, J., de Salas-Quiroga, A., Garcez, P.P., Parsons, M., Andradas, C., Paraíso-Luna, J., García-Rincón, D., Sánchez, C., Guillemot, F., Guzmán, M., Galve-Roperh, I. 

Cerebral Cortex 2017

 

VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington’s disease

Díaz-Alonso, J., Paraíso-Luna, J., Navarrete, C., del Río, C., Cantarero, I., Palomares, B., Aguareles, J., Fernández-Ruiz, J.J., Luz-Bellido, M., Pollastro, F., Appendino, G., Calzado, M.A., Galve-Roperh, I., Muñoz. E. 

Scientific Reports 2016

 

Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons

de Salas-Quiroga, A., Díaz-Alonso, J., García-Rincón, D., Remmers, F., Vega, D., Gómez-Cañas, M., Lutz, B., Guzmán, M., Galve-Roperh, I. 

Proceedings of the National Academy of Sciences of the United States of America 2015

 

Δ9-tetrahydrocannabinol alone and combined with cannabidiol mitigate fear memory through reconsolidation disruption

Stern, C.A., Gazarini, L., Vanvossen, A.C., Zuardi, A.W., Galve-Roperh, I., Guimaraes, F.S., Takahashi, R.N., Bertoglio, L.J. 

European Neuropsychopharmacology 2015

 

CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex

Díaz-Alonso, J., Aguado, T., de Salas-Quiroga, A., Ortega, Z., Guzmán, M., Galve-Roperh, I. 

Cerebral Cortex 2014

 

Cannabinoids, neurogenesis and antidepressants drugs: is there a link?

Viar-Fogaça, M., Galve-Roperh, I., Guimarães, F.S., Campos, A.C. 

Current Neuropharmacology 2013

 

Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation

Galve-Roperh, I., Chiurchiù, V., Díaz-Alonso, J., Bari, M., Guzmán, M., Maccarrone, M. 

Progress in Lipid Research 2013

 

Anandamide deficiency and heightened neuropathic pain in aged mice

Bishay, P., Häussler, A., Lim, H-Y., Oertel, B., Galve-Roperh, I., Ferreirós, N., Tegeder, I. 

Neuropharmacology 2013

 

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

Campos, A.C.,  Ortega, Z., Palazuelos, J., Fogaça, M.V., Aguiar, D.C., Díaz-Alonso, J., Ortega-Gutiérrez, S., Vázquez-Villa, H., Moreira, F.A., Guzmán, M, Guimarães, F.S., Galve-Roperh, I. 

International Journal of Neuropsychopharmacology 2013

 

CB1 cannabinoid receptors drive corticospinal motor neuron specification through the Ctip2/Satb2 transcriptional regulation axis

Díaz, J., Aguado, T., Wu, C., Palazuelos, J., Hofmann, C., Garcez, P., Guillemot, F., Lu, H.C., Lutz, B., Guzmán, M., Galve-Roperh, I. 

Journal of Neuroscience 2012

 

 Endocannabinoids via CB1 receptors act as neurogenic niche cues during cortical development

Díaz-Alonso, J., Guzmán, M., Galve-Roperh, I. 

Philosophical Transactions of the Royal Society 2012

 

CB2 cannabinoid receptors promote neural progenitor cell proliferation via mTORC1 signaling

Palazuelos, J., Ortega, Z., Díaz-Alonso, J., Guzmán, M., Galve-Roperh, I. 

Journal of Biological Chemistry 2012