JEFE DE GRUPO (TUMORES CEREBRALES): GUILLERMO VELASCO

 

The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer

Orea-Soufi, A., Castillo-Lluva, S., Salvador-Tormo, N., Martín-Cabrera, P., Recuero, S., Gabicagogeascoa, E., Moreno-Valladares, M., Mendiburu-Eliçabe, M., Blanco-Gómez, A., Ramos-Pittol, J.M., García-Taboada, E., Ocaña, A., Cimas, F.J., Matheu, A., Álvarez-López, I., Velasco, G., Lorente, M. 

Cancers 2021

 

Midkine signaling maintains the self-renewal and tumorigenic capacity of glioma initiating cells

López-Valero, I., Dávila, D., González-Martínez, J., Salvador-Tormo, N., Lorente, M., Saiz-Ladera, C., Torres, S., Gabicagogeascoa, E., Hernández-Tiedra, S., García-Taboada, E., Mendiburu-Eliçabe, M., Rodríguez-Fornés, F., Sánchez-Domínguez, R., Segovia, J.C., Sánchez-Gómez, P., Matheu, A., Sepúlveda, J.M., Velasco, G.

Theranostics 2020

 

Targeting Glioma Initiating Cells with A combined therapy of cannabinoids and temozolomide

López-Valero, I., Sáiz-Ladera, C., Torres, S., Hernández-Tiedra, S., García-Taboada, E., Rodríguez-Fornés, F., Barba, M., de León, D.D., Salvador-Tormo, N., Guzmán, M., Sepúlveda, J.M., Sánchez, P., Lorente, M., Velasco, G. 

Biochemical Pharmacology 2018

 

Optimization of a preclinical therapy of cannabinoids in combination with temozolomide against glioma

López-Valero, I., Torres, S., Salazar-Roa, M., García-Taboada, E., Hernández-Tiedra, S., Guzmán, M., Sepúlveda, J.M., Velasco, G., Lorente, M.

Biochemical Pharmacology 2018

 

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Hernández-Tiedra, S., Fabrias, G., Dávila, D., Salanueva, I., Casas, J., Montes, R., Antón, Z., García-Taboada, E., Salazar-Roa, M., Lorente, M., Nylandsted, J., Armstrong, J., López- Valero, I., McKee, C., Serrano-Puebla, A., García-López, R., González-Martínez, J., Abad, J., Hanada, K., Boya, P., Goñi, F., Guzmán, M., Lovat, P., Jaattela, M., Alonso, A., Velasco, G.

Autophagy 2016

 

The complex relationship of Tribbles pseudokinase 1, PML/RARA and C/EBPα in leukemia: two possible couples but not a trio

Velasco, G.

Haematologica 2016

 

Anticancer mechanisms of cannabinoids

Velasco, G., Sánchez, C., Guzmán, M.

Current Oncology 2016

 

The use of cannabinoids as anticancer agents

Velasco, G., Hernández-Tiedra, S., Dávila, D., Lorente, M.

Progress in Neuro-Psychopharmacology & Biological Psychiatry 2016

 

Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death

Armstrong, J.L., Hill, D.S., McKee, C.S., Hernandez-Tiedra, S., Lorente, M., Lopez-Valero, I., Eleni Anagnostou, M., Babatunde, F., Corazzari, M., Redfern, C.P., Velasco, G.*, Lovat P*.

Journal of Investigative Dermatology 2015

 

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

Cianfanelli, V., Fuoco, C., Lorente, M., Salazar, M., Quondamatteo, F., Gherardini, P.F, De Zio, D., Nazio, F., Antonioli, M., D’Orazio, M., Skobo, T., Bordi, M., Rohde, M., Dalla Valle, L., Helmer-Citterich, M., Gretzmeier, C., Dengje, l. J., Fimia, G.M., Piacentini, M., Di Bartolomeo, S., Velasco, G., Cecconi, F.

Nature Cell Biology 2015

 

 Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation

Salazar, M.*, Lorente, M.*, García-Taboada, E., Pérez-Gómez, E., Dávila, D., Zúñiga-García, P., María-Flores, J., Rodríguez, A., Hegedus, Z., Mosén-Ansorena, D., Aransay, A.M., Hernández-Tiedra, S., López-Valero, I., Quintanilla, M., Sánchez, C., Iovanna, J.L., Dusetti, N., Guzmán, M., Francis, S.E., Carracedo, A., Kiss-Toth, E., Velasco, G.

Cell Death & Differentiation 2015

 

Oncosuppressive functions of tribbles pseudokinase 3

Salazar, M., Lorente, M., Orea-Soufi, A., Dávila, D., Erazo, T., Lizcano, J., Carracedo, A., Kiss-Toth, E., Velasco, G.

Biochemical Society Transactions 2015

 

Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme

Hernán-Pérez de la Ossa, D.*, Lorente, M*., Gil-Alegre, M.E., Torres, S., García-Taboada, E., Aberturas, M del R., Molpeceres, J., Velasco, G.*, Torres-Suárez, A.I.*

PLoS One 2013

 

The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action

Salazar, M., Lorente, M., García-Taboada, E., Hernández-Tiedra, S., Davila, D., Francis, S.E., Guzmán, M., Kiss-Toth, E., Velasco, G.

Biochimica et Biophysica Acta 2013