Papers
PAPERS
Metal-Free Aminophosphonation: Eco-friendly Synthesis and Photophysical Properties of Fluorescent 3-(Aminoimidazo[1,2-a]pyridin-2-yl)phosphonates
Roscales, S.; Csáky, A. G. Angew. Chem., Int. Ed. 2024, 63, e202412300
Kudos Summary: Eco-Friendly Synthesis of Aminophosphonates with Unique Fluorescence
(Ph3P)AuCl-catalyzed homocoupling of arylboronic acids under benchtop conditions: Synthesis of biphenyls
Roscales, S.; Sánchez-Sancho, F.; Csáky, A. G. Molecular Catalysis 2023, 547, 113281
Searching for Highly Active Cobalt Catalysts Bearing Schiff Base Ligands for Markovnikov-Selective Hydrosilylation of Alkynes with Tertiary Silanes
Skrodzki, M.; Ortega Garrido,V.; Csáky, A. G.; Pawluć, P. Journal of Catalysis 2022, 411, 116
KUDOS SUMMARY: Disovering Efficient Cobalt Catalysts for Selective Chemical Reactions
Transition-metal-free Reductive Coupling of an 18F-Labeled Nitroarene with Boronic Acids as a Potential Access to 18F-Labeled Fenamates
Laube, M.; Roscales, S; Pietzsch, J.; Csákÿ, A. G. Nucl.Med.Biolol. 2021, 96-97, S74
Synthesis of Ketones by C-H Functionalization of Aldehydes with Boronic Acids under Transition-Metal-Free Conditions
Roscales, S; Csákÿ, A. G. Angew. Chem. Int. Ed. 2021, 60, 8728
KUDOS SUMMARY: Unlocking a Chemistry's Secret: Nitrosobenzene Unleashes Aldehyde Power for C-H to C-C Conversion
Transition-Metal-Free Three-Component Synthesis of Tertiary Aryl Amines from Nitro Compounds, Boronic Acids, and Trialkyl Phosphites
Roscales, S; Csákÿ, A. G. Adv.Synth. Catal.2020, 362, 111
KUDOS SUMMARY: Unlocking the Power of "Boronics": Easy Method for Creating Tertiarty Aryl Amines from "Nitros"
Synthesis of Mono-N-Methyl Aromatic Amines from Nitroso Compounds and Methylboronic Acid
Roscales, S; Csákÿ, A. G. ACS OMEGA 2019, 4, 13943
KUDOS SUMMARY: Mono-N-Methyl/Alkyl Amines: Synthesis without overalkylation
Selective Functionalization of Achmatowicz Rearrangement Products by Reactions with Potassium Organotrifluoroborates under Transition-Metal-Free Conditions
Roscales, S; Ortega, V.; Csákÿ, A. G. J. Org. Chem. 2018, 83, 11425
Synthesis of Di(hetero)arylamines from Nitrosoarenes and Boronic Acids: A General, Mild, and Transition-Metal-Free Coupling
Roscales, S; Csákÿ, A. G. Org. Lett. 2018, 20, 1667
Towards understanding the behavior of polyelectrolyte – surfactant mixtures at the water / vapor interface closer to technologically-relevant conditions
Llamas, S.; Akkano, A.; Fernández-Peña, L.; Guzmán, E.; Ortega, F.; Csáky, A. G.; Ortega, V.; Campbell, R. A.; Miller, R.; Rubio, R. G. Phys. Chem. Chem. Phys. 2018, 20, 1395.
Transition Metal-Free Stereocomplementary Cross-Coupling of Diols with Boronic Acids as Nucleophiles
Ortega, V.; del Castillo, E.; Csákÿ, A. G. Org. Lett. 2017, 29, 6236
Ring-opening of donor-acceptor cyclopropanes by boronic acids and potassium organotrifluoroborates under transition-metal-free conditions.
Ortega, V.; Csákÿ, A. G. J. Org. Chem. 2016, 81, 3917
Transition-metal Free reactions of boronic acids: Cascade addition – ring-opening of furans towards functionalized γ-Ketoaldehydes.
Roscales, S.; Csákÿ, A. G. Chem. Commun. 2016, 52, 3018
Metal-Free Conjugate Addition of Alkenylboronic Acids to Enedicarbonyl Compounds towards the Synthesis of Pyridazine Derivatives.
Roscales, S.; Sancho, A.; Csákÿ, A. G. Synthesis 2015, 47, 2233 (Special Issue focused on Conjugate Addition Methods, Invited Contribution by Editor, Prof. E. M. Carreira).
Transition-Metal-Free Direct anti-Carboboration of Alkynes with Boronic Acids to Produce Alkenylheteroarenes.
Roscales, S.; Csákÿ, A. G. Org. Lett. 2015, 17, 1605.
1,2-Stereochemical Induction in the PdII-Catalyzed Conjugate Addition of Boronic Acids.
Roscales, S.; Sánchez, F.; Csákÿ, A. G. Eur. J. Org. Chem. 2015, 1754.
Metal-free ring-opening of epoxides with potassium trifluoroborates.
Roscales, S.; Csákÿ, A. G. Chem. Commun. 2014, 50, 454.
Metal free reactions of boronic acids: 1,3-Stereochemical induction in the substrate-controlled conjugate addition.
Roscales, S.; Ortega, V.; Csákÿ, A. G. J. Org. Chem. 2013, 78, 12830.
Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer´s disease.
Jiménez-Aliaga, K.; Bermejo-Bescós, P .; Martín-Aragón, S.; Csákÿ, A. G. Bioorg. Med. Chem. Lett. 2013, 23, 426.
Stereoselective synthesis of indanylglycine derivatives by a tandem Michael – Michael reaction.
Rincón, A.; Carmona, V.; Torres, M. R.; Csákÿ, A. G. Synlett 2012, 23, 2656.
Pd(II)-catalyzed conjugate addition of boronic acids to ketoglutaconic esters toward the synthesis of functionalyzed pyridazin-3(2H)-ones with neuroprotective activity.
Roscales, S.; Ortega, A.; Martín-Aragón, S.; Bermejo-Bescós, P.; Csákÿ, A. G. Eur. J. Org. Chem. 2012, 5398.
Trifluoroacetic anhydride promoted tandem conjugate addition of boronic acids/acetal ring opening.
Roscales, S.; Csákÿ, A. G. Org. Lett. 2012, 14, 1187.
Trifluoroacetic anhydride-catalyzed conjugate addition of boronic acids to α,β-unsaturated ketones.
Roscales, S.; Rincón, A.; Buxaderas, E.; Csákÿ, A. G. Tetrahedron Lett. 2012, 53, 4724.
Regioselective 1,6-conjugate addition of boronic acids and Grignard reagents to dienylpyridines.
Roscales, S.; Salado, I. G.; Csákÿ, A. G. Synlett 2011, 2234.
Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils.
Ortega, A.; Rincón, A.; Jiménez-Aliaga, K. L.; Bermejo-Bescós, P.; Martín-Aragón, S.; Molina, M. T.; Csákÿ, A. G. Bioorg. Med. Chem. Lett. 2011, 21, 2183.
In vitro antiamyloidogenic properties of 1,4-naphthoquinones.
Bermejo-Bescós, P.; Martín-Aragón, S.; Jiménez-Aliaga, K. L.; Ortega, A.; Molina, M. T.; Buxaderas, E.; Orellana, G.; Csákÿ, A. G. Biochem. Biophys. Res. Commun. 2010, 400, 169.
ORGANIC CHEMISTY PORTAL CITATIONS
REVIEWS
- Chemical Society Reviews
How to Make C–N Bonds Using Boronic Acids and their Derivatives without Transition Metals
Roscales, S; Csákÿ, A. G. Chem. Soc. Rev. 2020, 49, 5159
KUDOS SUMMARY: How to make C-N bonds using boronic acids without transition metals
Transition-metal-free C–C Bond-forming Reactions of Aryl, Alkenyl and Alkynylboronic Acids and their Derivatives
Roscales, S.; Csákÿ, A. G. Chem. Soc. Rev. 2014, 43, 8215.
Conjugate Addition Reactions of Carbon Nucleophiles to Electron-deficient Dienes
Csákÿ, A. G.; de la Herrán, G.; Murcia, M. C. Chem. Soc. Rev. 2010, 39, 4080.
- Other contributions
Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions
Sánchez-Sancho, F.; Escolano, M.; Gaviña, D.; Csáky, A.G.; Sánchez-Roselló, M.; Díaz-Oltra, S.; del Pozo, C. Pharmaceuticals 2022, 15, 948
C–C Bond Formation with Boronic Acids and Derivatives by Transition-metal-free Conjugate Addition Reactions
Csákÿ, A. G., Sánchez-Sancho, F. Synthesis 2016, 48, 2165.
1,2-Bis(diphenylphosphino)benzene.
Csákÿ, A. G.; Molina, M. T. Electronic encyclopedia of reagents for organic synthesis (EROS).
Naturally occurring δ-hydroxy-γ-lactones: Muricatacins and related compounds
Murcia, M.C.; Navarro, C.; Moreno, A.; Csákÿ, A. G. Current Organic Chemistry, 2010, 14, 15
PATENTS
Derivatives of Imidazo[1,2-a]pyridine with anti-inflammatory activity.
Sánchez‐Sancho, F.; Csáky, A. G.; del Pozo, C; del Pozo, J.; Marcilla, A.; Ibázez Cabeza, B.; Oliver, E. Cumella, J. M.; Roscales, S.
Patent WO2025003545. PCT extension PCT/ES2024/ 070403 (26706/2024). In exploitation by IMHOTECH LABORATORIES, SL.
Herstellung von 18F-markierten Verbindungen aus Nitroso-substituierten Arenen.
Roscales, S.; Csáky, A. G.; Laube, M.; Pietzsch, J.
GERMAN Patent Application, DE 10 2024 138 695.9 (18/12/2024). Applicant: HZDR, UCM.
CHEMICAL EDUCATION
Synthesis of Flufenamic Acid: An Organic Chemistry Lab Sequence using Boronic Acids and Nitrosoarenes under Transition-Metal-Free Conditions
Roscales, S; Csákÿ, A. G. J. Chem. Educ. 2019, 96, 1738
KUDOS SUMMARY: Making Flufenamic Acid with Boronic Acids & Nitrosoarenes – A Lab Adventure for Chemistry Students
CONGRESSES
Development of New Transition-Metal-Free C-N and C-C Bond-Forming Reactions of Boronic Acids (poster)
Silvia Roscales, Víctor Ortega, Francisco Sánchez-Sancho, Aurelio G. Csákÿ*
XXVII Biennial Meeting in Organic Chemistry, Santiago de Compostela (Spain), 20 - 22 June, 2018
Development of new 18F-PET radiotracers for in vivo diagnose of tauopathies. Synthesis of new candidates and SPR affinity studies (poster)
Gracia Baquero Gálvez, A. M. González Fuente, F. Sánchez-Sancho,* Aurelio G. Csäky*
XXVII Biennial Meeting in Organic Chemistry, Santiago de Compostela (Spain), 20 - 22 June, 2018
Development of New Transition-Metal-Free C-N Bond-Forming Reactions of Boronic Acids: Synthesis of Amines (Oral presentation)
Silvia Roscales*, Aurelio G. Csaky
XXXVII Reunión Bienal de la Real Sociedad Española de Química, San Sebastián (Spain), 26 - 30 May, 2019
Transition-metal-free reductive coupling of an 18F-labeled nitro-arene with boronic acids as a potential access to 18F-labeled fenamates (poster + short explainer video)
Markus Laube,* Silvia Roscales, Jens Pietzsch, Aurelio G. Csáky
eSRS 2021 Virtual Meeting, Society of Radiopharmaceutical Sciences, 17 - 19 May, 2021
New LDH inhibitors related to stiripentol: controlled release from poly(vinylpyrrolidone) copolymers (Poster)
Silvia Roscales García,* Isabel Martínez Martínez,, Alberto Gallardo, Helmut Reinecke, Carlos Elvira, Rubén García Sobrino, Enrique Martínez Campos, Jannier Carranza Avila, Francisco Sánchez Sancho, Aurelio Garcia Csaky
XXXVIII Reunión Bienal de la Sociedad Española de Química (RSEQ) 2022, Granada (Spain), 27 - 30 June, 2022
Development of (Ph3P)AuCl-catalyzed homocoupling of arylboronic acids under benchtop conditions (Poster)
Silvia Roscales García,* Francisco Sánchez Sancho, Aurelio Garcia Csaky
XXXIX Reunión Bienal de la Sociedad Española de Química (RSEQ) 2023, Zaragoza (Spain), 25 - 29 June, 2023
Tris(pentafluorophenylborane)-catalyzed C-H Phosphonylation of Imidazo[1,2-a]pyridines: Synthesis of 3-aminoimidazo[1,2-a]pyridin-2-yl phosphonates (Poster)
Silvia Roscales García,* Aurelio Garcia Csaky
XXIX Reunión Bienal de Química Orgánica (RSEQ) 2024, Tenerife (Spain), 26 - 28 June, 2024