Research Career

•  06/2006–present. Immunomedicine Group Leader. Department of Immunology, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain

  • Topic: Immunomedicine and Immunonformatics.

• 07/2005–06/2006. Director of the Department of Bioinformatics of the Cancer Vaccine Center. Dana-Farber Institute, Harvard Medical School, Boston, MA, USA

  • Topic: Computational Immunology and Cancer Immunothrerapy.

  • Reporting to: Prof. Ellis L. Reinherz, Director

• 03/2001–06/2006. Research Scientist. Dana-Farber Institute, Harvard Medical School, Boston, MA, USA

  • Topic: Molecular basis of Immune Recognition.

  • Reporting to: Prof. Ellis L. Reinherz, Chief of the laboratory of Immunobiology

•  05/1998–02/2001. Postodoctoral Scientist at DNAX, Research Institute, Palo Alto, CA, USA.

  • Topic: Discovery and functional analysis of novel molecules.

  • Funding: Post-Doctoral Fellowship from DNAX Research Institute

  • Supervisor: Dr. Fernando J. Bazan

•  09/1995–06/1998. Post-doctoral Scientist at Dept. of Biochemistry, University of Cambridge, UK.

  • Topic: Molecular and structural bases of the post-translational modification of biotinyl and lipoyl domains. Protein-protein interactions underlying catalysis and protein assemble in multienzyme complexes.

  • Funding: FEBS Fellowship (09/1995 – 08/1997) and BBSRC Research Associate contract (09/1997–05/1998)

  • Supervisor: Prof. Richard N. Perham

•  09/90-06/95 PhD Student at Instituto de Parasitología y Biomedicina" (CSIC), Granada, Spain.

  • Topic: Identification and characterization of potential drug targets in Trypanosoma cruzi

  • Funding: PhD Fellowship from Junta de Andalucia, Spain

  • Supervisor: Dr. Luis Miguel Ruiz Perez & Dra. Dolores Gonzalez Pacanowska

Academic appointments

•  07/2011-present. Professor of Immunology: Department of Immunology, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain

•  09/2012-09/2015. Coordinator of the Master in Research in Inmunology, Facultad of Medicina (School of Medicine), Universidad Complutense de Madrid, Madrid, Spain (http://www.ucm.es/info/inmuno/master.htm)

•  04/2011-07/2011. Visiting Professor: Department of Microbiology I (Immunology), Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain

•  04/2006-04/2011. Academic and Investigator Personnel (Personal Académico e Investigador Ramón y Cajal): Department of Microbiology I (Immunology), Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain

•  02/2001-06/2006. Instructor of Medicine. Department of Medical Oncology, Harvard Medical School, Boston, MA

Selected teaching activity

•  2007-present. Principles of Immunology, Biochemistry, Medicine and Biology Majors, UCM, Spain (Course Director: Pedro A Reche)
•  2010-present. Immunotechnology, Master of Immunology; School of Medicine, Universidad Complutense de Madrid (UCM), Spain (Course Director: Dr. Pedro A Reche)
• Immunochemistry and Cellular Immunology, Biochemistry major, second cycle; School of Chemistry, UCM, Spain (Course Director: Pedro A Reche)
• 200-2015. Immunoinformatics,  Master of Bioinformatics,  National School of Health (Course Director: Federico Morán)

•  2006-2007. Bioinformatics Approaches in Immunology Research; Instituto Gulbenkian de Ciencia, Oeiras,  Portugal (Course Organizer: Pedro Fernandes)
•  2003-2006. Components of Antigen Processing and Presentation, Molecular Basis of Human Disease course;   Harvard Medical School, USA (Course Director: Edmond Yunis).

Awards and Fellowships

•  09/1995–09/1997. Post-Doctoral Fellowship, Federation of European Biochemistry Societies (FEBS)
•  03/1994–05/1994. Short Term Pre-Doctoral Research Fellowship, European Science Exchange Program, The Royal Society, UK.

•  03/1994–05/1994.  Short Term Pre-Doctoral Research Fellowship, Junta de Andalucía, Spain.
•  10/1990–09/1994.  PhD Fellowship, Junta de Andalucía, España
•  09/1988–09/1990.  Undergraduate Research Fellowship, Ministerio de Educación y Ciencia, España.

Editorial and review activity

• Ad hoc reviewer for BMC journals, Bioinformatics, Nucleic Acid Res., Nature Biotechnology, etc.

• Associate Editor of Bioinformation (2007-present)

• Associate Editor of Immunology and Immunogenetic Insights (2011-present)

• Editorial Board Current Computer-Aided Drug Design (2011-present)

• Associate Editor Network Modeling Analysis in Health Informatics and Bioinformatics (2013-2021)

•  Associate Editor Journal of Immunology Research (2015-present)
•  Associate Editor of Vaccines (2017-present)
•  Associate Editor of Frontiers in Immunology (2018-present)

• Lead Guest Editor of a bi-yearly special issue on Peptide-Based vaccines and immunotherapeutics for Journal of  Immunology Research (2013-2017)

• Reviewer of HHS/NIH/NIAID research contract for large scale epitope identification

Report of selected competitive funding

•  Desarrollo asistido por computadora de vacunas de epitopos: aplicacion al Rhinovirus humano.

• Source: Ministerio de Economía y Competividad, Spain (REF: BIO2014-54164-R)

  • From:  01/10/2015 to 30/09/2018

  • Role:  Principal Investigator

•  Development of bacterial immunopotenciator to prevent chronic pulmonary diseases.
  •  Source: Ministerio de Innovación y Ciencia, Spain (REF: IPT-2012-0639-090000)
  •  From:  01/01/2013 to 31/12/2015
  •  Role: Co-Principal Investigator

• Pan-individual stimulation of T cell immune response against conserved CD8 T cell epitopes from hepatitis C virus.

  •  Source: Ministerio de Innovación y Ciencia, Spain (SAF2009-08103)
  •  From:  01/01/2010 to 31/12/2012
  •  Role: Principal Investigator
•  Computer-aided design of epitope vaccines: application to hepatitis C virus
  •  Source: Comunidad Autonoma de Madrid, Spain(CCG08-UCM/BIO-3769)
  •  From: 01/01/2009 to  28/02/2010
  •  Role: Principal Investigator
•  Bioinformatics Resources for immunotherapy against cancer
  •  Source: Ministerio de Educación y Ciencia, Spain (SAF2006-07879)
  •  From:  30/09/2006 to 31/03/2010
  •  Role: Principal Investigator

Patents

•  Title: Mammalian cytokines; receptors; related reagents and methods.
  •  Inventors: Pedro A Reche-Gallardo, Vassili Soumelis, Yong-Jun Liu, Rene de Waal Malefyt, Bazan J. Fernando, Robert A. Kastelein
  •  Patent Nº: 7569224 B2
  •  Holder: Schering Corporation

•  Title: Identifying antibody that inhibits pathogenicity of infectious microorganism such as an orthopox virus using a programmed computer
  •  Inventors: Pedro A. Reche and Ellis E. Reinherz
  •  Application Number: US2003229454-A1; WO2004040398-A2; AU2003299469-A1; AU2003299469-A8
  •  Holder: Dana-Farber Cancer Institute

•  Title: New IKBNS gene, useful for preparing a composition for treating e.g. cancer, malaria, tuberculosis, AIDS or autoimmune disease, such as rheumatoid arthritis, diabetes mellitus or multiple sclerosis
  •  Inventors: Ellis L. Reinherz, Linda K. Clayton, Emma Fiorini, Pedro A. Reche, Ingo Schmitz
  •  Application Number: WO2003018776-A; WO2003018776-A2; AU2002258548-A1; US2005084916-A1; AU2002258548-A8
  •  Holder: Dana-Farber Cancer Institute

•  Title: New computer-assisted method of generating an immunogen by providing a pathogenesis factor (PI;) or its fragment and determining whether the produced compound is an immunogen in a mammalian host
  •  Inventors : Ellis L Reinherz, Mikyung Kim, Pedro A Reche and Jia-Huai Wang.
  •  Application Number: WO2003017032-A2; EP1417628-A2; AU2002326580-A1; US2005015232-A1; AU2002326580-A8
  •  Holder: Dana-Farber Cancer Institute