Departamentos

  1. Portada
  2. Sede departamental BBM de Química
  3. [...]
  4. Biomateriales - Interacciones célula-biomaterial
  5. Biomateriales - Interacciones célula-biomaterial

Biomateriales - Interacciones célula-biomaterial


Miembros del Grupo

Group Members

  • Mª Teresa Portolés

Catedrática

  • Mª José Feito

Profesora Titular

  • Laura Casarrubios

Alumna Predoctoral

  • Mónica Cicuéndez

Investigadora Postdoctoral

  • Alberto Polo Montalvo

Graduado en Bioquímica



Publicaciones recientes

Recent publications

  • M. Cicuéndez, A. García-Lizarribar, L. Casarrubios, M.J. Feito, F.J. Fernández-San-Argimiro, N. García-Urkia, O. Murua, I. Madarieta, B. Olalde, R. Diez-Orejas, M.T. Portolés (2024) “Functionality of macrophages encapsulated in porcine decellularized adipose matrix hydrogels and interaction with Candida albicans” Biomaterials Advances 2024, 159, 213794
  • J. Jiménez-Holguín, D. Lozano, M. Saiz-Pardo, D. de Pablo, L. Ortega, S. Enciso, B. Fernández-Tomé, I. Díaz-Güemes, F.M. Sánchez-Margallo, M.T. Portolés, D. Arcos (2024) “Osteogenic-angiogenic coupled response of cobalt-containing mesoporous bioactive glasses in vivo” Acta Biomaterialia 2024, 176, 445-457
  • A. Polo-Montalvo, M. Cicuéndez, L. Casarrubios, N. Barroca, D. Silva, M.J. Feito, R. Diez-Orejas, M.C. Serrano, P.A.A.P. Marques, M.T. Portolés (2023) “Effects of graphene oxide and reduced graphene oxide nanomaterials on porcine endothelial progenitor cells” Nanoscale 2023, 15: 17173–17183, Collection on “Graphene and 2D Materials in Healthcare”
  • L. Casarrubios, M. Cicuéndez, M.V. Vallet-Regí, M.T. Portolés, D. Arcos, M.J. Feito (2023) “Osteoimmune properties of mesoporous bioactive nanospheres: A study on T helper lymphocytes” Nanomaterials 2023, 13: 2183
  • E. Benayas, A. Espinosa, M.T. Portolés, V. Vila-del Sol, M.P. Morales, M.C. Serrano (2023) “Cellular and molecular processes are differently influenced in primary neural cells by slight changes in the physico-chemical properties of multicore magnetic nanoparticles” ACS Appl. Mater. Interfaces 2023, 15, 17726−17741
  • D. Arcos, M.T. Portolés (2023) “Mesoporous Bioactive Nanoparticles for Bone Tissue Applications” Int. J. Mol. Sci. 2023, 24, 3249
  • C.I.M. Santos, M. Cicuéndez, G. Gonçalves, L. Rodríguez-Pérez, M.T. Portolés, M.A.F. Faustino, M.A. Herranz, M.G.P.M.S. Neves, J.M.G. Martinho, E.M.S. Maçôas, N. Martín (2023) “Safety assessment of new nanodiamonds@corrole hybrids addressed by the response of RAW-264.7 macrophages” J. Mater. Chem. B., 11, 675
  • J. Jiménez-Holguín, D. Arcos, D. Lozano, M. Saiz-Pardo, D. de Pablo, L. Ortega, S. Enciso, B. Fernández-Tomé, I. Díaz-Güemes, F. M. Sánchez-Margallo, L. Casarrubios, M.T. Portolés, M. Vallet-Regí (2022) “In vitro and in vivo response of zinc-containing mesoporous bioactive glasses in a sheep animal model” Int. J. Mol. Sci., 23, 13918
  • M.J. Feito, M.Cicuéndez, L.Casarrubios, R.Diez-Orejas, S.Fateixa, D.Silva, N.Barroca, P.A.A.P.Marques, M.T.Portolés (2022) “Effects of Graphene Oxide and Reduced Graphene Oxide Nanostructures on CD4+Th2 Lymphocytes” Int. J. Mol. Sci., 23, 10625
  • D. Arcos, N. Gómez-Cerezo, M. Saiz-Pardo, D. de Pablo, L. Ortega, S. Enciso, B. Fernández-Tomé, I. Díaz-Güemes, F. M. Sánchez-Margallo, L. Casarrubios, M.J. Feito, M.T. Portolés, M. Vallet-Regí (2022) “Injectable Mesoporous Bioactive Nanoparticles Regenerate Bone Tissue under Osteoporosis Conditions” Acta Biomater. 151, 501–511
  • A.F. Girão, J. Sousa, M. Cicuéndez, M.C. Serrano, M.T. Portolés, P.A.A.P. Marques (2022) “Tailoring 3D biomaterials for spinal cord injury repair” in Engineering Biomaterials for Neural Applications: Targeting Traumatic Brain and Spinal Cord Injuries, pp 57-78, Springer International Publishing (Verlag) (Eds. E. López-Dolado, M.C. Serrano) Switzerland
  • M.J.Feito, L.Casarrubios, M.Oñaderra, M.Gómez-Duro, P.Arribas, A.Polo-Montalvo, M.Vallet-Regí, D.Arcos, M.T.Portolés (2021) "Response of RAW 264.7 and J774A.1 macrophages to microparticles and nanoparticles of mesoporous bioactive glass: A comparative study" Colloids Surf. B, 208, 112110
  • C.Matesanz, M.Villa-Carvajal, J.Linares, S.Morante-Zarcero, I.Sierra, E.Barreno, M.Catalá, M.T.Portolés (2021) “Chemical characterization of the lichen-symbiont microalga Asterochloris erici and study of its cytostatic effect on the L929 murine fibrosarcoma cell line” Processes, 9, 1509
  • A.Polo-Montalvo, L.Casarrubios, M.C.Serrano, A.Sanvicente, M.J.Feito, D.Arcos y M.T.Portolés (2021) “Effective actions of ion release from mesoporous bioactive glass and macrophage mediators on the differentiation of osteoprogenitor and endothelial progenitor cells” Pharmaceutics, 2021, 13, 1152, Special Issue: “Commemorative Issue in Honor of Professor Maria Vallet Regí: 20 Years of Silica-Based Mesoporous Materials”
  • M.Cicuéndez, L.Casarrubios, N.Barroca, D.Silva, M.J.Feito, R.Diez-Orejas, P.A.A.P.Marques y M.T.Portolés (2021) “Benefits in the Macrophage Response Due to Graphene Oxide Reduction by Thermal Treatment” Int. J. Mol. Sci. 2021, 22, 6701, Special Issue: “Carbon-Based Nanomaterials”
  • M.Cicuéndez, L.Casarrubios, M.J.Feito, I.Madarieta, N.Garcia-Urkia, O.Murua, B.Olalde, N.Briz, R.Diez-Orejas y M.T.Portolés (2021) “Candida albicans/macrophage biointerface on human and porcine decellularized adipose matrices” J. Fungi 2021, 7, 392, Special Issue: “Host Defense against Fungi”
  • L.Casarrubios, A.Polo-Montalvo, M.C.Serrano, M.J.Feito, M.Vallet-Regí, D.Arcos, M.T.Portolés (2021) “Effects of ipriflavone-loaded mesoporous nanospheres on the differentiation of endothelial progenitor cells and their modulation by macrophages” Nanomaterials 11: 1102
  • M.Cicuéndez, L.Casarrubios, M.J.Feito, I.Madarieta, N.Garcia-Urkia, O.Murua, B.Olalde, N.Briz, R.Diez-Orejas, M.T.Portolés (2021) “Effects of human and porcine adipose extracellular matrices decellularized by enzymatic or chemical methods on macrophage polarization and immunocompetence” Int. J. Mol. Sci. 22: 3847
  • R.Diez-Orejas, L.Casarrubios, M.J.Feito, J.M.Rojo, M.Vallet-Regí, D.Arcos, M.T.Portolés (2021) “Effects of mesoporous SiO2-CaO nanospheres on the murine peritoneal macrophages / Candida albicans interface” Int. Immunopharmacol. 94: 107457
  • M.T.Portolés, L. Casarrubios (2020) “Cell Responses to Mesoporous Bioactive Glasses” in “Bioactive Glasses. Properties, Composition and Recent Applications”, Chapter Nº 8, 275-303 Nova Science Publishers, Inc. (Eds. D. Arcos, M. Vallet-Regí) New York
  • L.Casarrubios, N.Gómez-Cerezo, M.J.Feito, M.Vallet-Regí, D.Arcos, M.T.Portolés (2020) "Ipriflavone-loaded mesoporous nanospheres with potential applications for periodontal treatment" Nanomaterials 10, 2573; doi:10.3390/nano10122573, Special issue on "Nano-Engineering Solutions for Dental Implant Applications"
  • M. Montes-Casado, A. Sanvicente, L. Casarrubios, M.J. Feito, J.M. Rojo, M. Vallet-Regí, D. Arcos, P. Portolés, M.T. Portolés (2020) "An Immunological Approach to the Biocompatibility of Mesoporous SiO2-CaO Nanospheres" Int. J. Mol. Sci.21, 8291, doi: 10.3390/ijms21218291
  • L. Casarrubios, N. Gómez-Cerezo, S. Sánchez-Salcedo, M.J. Feito, M.C. Serrano, M. Saiz- Pardo, L. Ortega, D. de Pablo, I. Díaz-Güemes, B. Fernández-Tomé, S. Enciso, F.M. Sánchez-Margallo, M.T. Portolés, D. Arcos, M. Vallet-Regí (2020) "Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep" Acta Biomater. 101: 544–553
  • M.Cicuéndez, M.Fernandes, M.Ayán-Varela, H.Oliveira, M.J.Feito, R.Diez-Orejas, J.I.Paredes, S.Villar-Rodil, M.Vila, M.T.Portolés, I.F.Duarte (2020) “Macrophage inflammatory and metabolic responses to graphene-based nanomaterials differing in size and functionalization” Colloids Surf., B 186: 110709
  • N.Gómez-Cerezo, L.Casarrubios, M.Saiz-Pardo, L.Ortega, D. de Pablo, I.Díaz-Güemes, B.Fernández-Tomé, S.Enciso, F.M.Sánchez-Margallo, M.T.Portolés, D.Arcos, M.Vallet-Regí (2019) "Mesoporous bioactive glass/-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep” Acta Biomater. 90: 393–402
  • M.Viñambres-Panizo, A.Domínguez-Bajo, M.T.Portolés, M.C.Serrano, M.Marciello (2019) “Nonviral Gene Therapy: Design and Application of Inorganic Nanoplexes” Nucleic Acid Nanotheranostics, Biomedical Applications, Chapter Nº 11, 365-390 Elsevier Inc. (Eds. M. Filice, J. Ruiz-Cabello) Netherland, United Kingdom, United States
  • M.J.Feito, R.Diez-Orejas, M. Cicuéndez, L. Casarrubios, J.M. Rojo, M.T. Portolés (2019) "Graphene oxide nanosheets modulate peritoneal macrophage polarization towards M1 and M2 phenotypes" Colloids Surf., B 176: 96-105
  • I.Izquierdo-Barba, L.Santos-Ruiz, J.Becerra, M.J.Feito, D.Fernández-Villa, M.C.Serrano, I.Díaz-Güemes, B.Fernández-Tomé, S.Enciso, F.M.Sánchez-Margallo, D.Monopoli, H.Afonso, M.T.Portolés, D.Arcos, M.Vallet-Regí (2019) "Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment" Acta Biomater. 83: 456-466
  • L.Casarrubios, N.Gómez-Cerezo, M.J.Feito, M.Vallet-Regí, D.Arcos, M.T.Portolés (2018) “Incorporation and effects of mesoporous bioactive glass nanospheres loaded with ipriflavone on osteoblast/osteoclast cocultures” Eur. J. Pharm. Biopharm. 133: 258-268
  • M.C.Serrano, M.J.Feito, A.González-Mayorga, R.Diez-Orejas, M.C.Matesanz, M.T.Portolés (2018) "Response of macrophages and neural cells in contact with reduced graphene oxide microfibers" Biomaterials Science 6: 2987-2997
  • R.Diez-Orejas, M.J.Feito, M.Cicuéndez, L.Casarrubios, J.M.Rojo, M.T.Portolés (2018) “Graphene oxide nanosheets increase Candida albicans killing by pro-inflammatory and reparative peritoneal macrophages” Colloids Surf., B 171: 250-259
  • N.Gómez-Cerezo, L.Casarrubios, I.Morales, M.J.Feito, M.Vallet-Regí, D.Arcos, M.T.Portolés (2018) "Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and macrophages" J. Colloid Interf. Sci. 528: 309-320
  • M.Cicuéndez, J.Flores, H.Oliveira, M.T.Portolés, M.Vallet-Regí, M.Vila, I.F. Duarte (2018) “Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyperthermia” Materials Science & Engineering C 91: 340-348
  • A.J.Salinas, J.M. Blanco-Becares, O.Mersinlioglu, L.Casarrubios, D.Fernández-Villa, M.J.Feito, M.T.Portolés, B. González, M.Vallet-Regí (2018) “Synthesis, characterization and biocompatibility study of mesolamellar calcium phosphate hybrids prepared via anionic surfactant templating” ChemistrySelect 3: 6880–6891
  • M.Cicuéndez, J.C.Doadrio, A. Hernández, M.T.Portolés, I.Izquierdo-Barba, M.Vallet-Regí (2018) "Multifunctional pH sensitive 3D scaffolds for treatment and prevention of bone infection" Acta Biomater. 65: 450-461
  • R.Diez-Orejas, M.J.Feito, M.Cicuéndez, J.M.Rojo, M.T.Portolés (2018) “Differential effects of graphene oxide nanosheets on Candida albicans phagocytosis by murine peritoneal macrophages” J. Colloid Interf. Sci. 512: 665–673
  • M.Cicuéndez, V.S.Silva, M.J.Hortigüela, M.C.Matesanz, M.Vila, M.T.Portolés (2017) “MC3T3-E1 pre-osteoblast response and differentiation after graphene oxide nanosheet uptake” Colloids Surf., B 158: 33-40
  • M.Maycas, M.T.Portolés, M.C.Matesanz, I.Buendía, J.Linares, M.J.Feito, D.Arcos, M.Vallet-Regí, L.Plotkin, P.Esbrit y A.R.Gortazar (2017) "High Glucose Alters the Secretome of Mechanically Stimulated Osteocyte-like Cells Affecting Osteoclast Precursors Recruitment and Differentiation" J. Cell. Physiol. 232: 3611-3621
  • M.T.Portolés y M.C.Serrano (2016) “Potentiality of Graphene-Based Materials for Neural Repair” En: Graphene-based Materials in Health and Environment, Chapter Nº 6: 157-188, Springer-Verlag (Eds. G. Gonçalves et al.) Germany
  • M.J.Feito, M.C.Serrano, M.Oñaderra, M.C.Matesanz, S.Sánchez-Salcedo, D.Arcos, M.Vallet-Regí y M.T.Portolés (2016) “Effects of immobilized VEGF on endothelial progenitor cells cultured on silicon substituted and nanocrystalline hydroxyapatites” RSC Adv. 6: 92586-92595
  • L.Casarrubios, M.C.Matesanz, S.Sánchez-Salcedo, D.Arcos, M.Vallet-Regí y M.T.Portolés (2016) “Nanocrystallinity effects on osteoblast and osteoclast response to silicon substituted hydroxyapatite” J. Colloid Interf. Sci. 482: 112-120
  • J.Linares, A.B.Fernández, M.J.Feito, M.C.Matesanz, S.Sánchez-Salcedo, D.Arcos, M.Vallet-Regí, J.M.Rojo y M.T.Portolés (2016) “Effects of nanocrystalline hydroxyapatites on macrophage polarization” J. Mater. Chem. B 4: 1951-1959
  • J.Linares, MC.Matesanz, M.J.Feito, H.J.Salavagione, G.Martínez, M.A.Gómez-Fatou y M.T.Portolés (2016) “Influence of the covalent immobilization of graphene oxide in poly(vinyl alcohol) on human osteoblast response" Colloids Surf., B 138: 50-59
  • C.Torres-Rodríguez, M.T.Portolés, M.C.Matesanz, J.Linares, M.J.Feito, I.Izquierdo-Barba, P.Esbrit y M.Vallet-Regí M (2016) “Effects of bleaching on osteoclast activity and their modulation by osteostatin and fibroblast growth factor 2” J. Colloid Interf. Sci. 461: 285-291
  • E.López-Dolado, A.González-Mayorga, M.T.Portolés, M.J.Feito, M.L.Ferrer, F.Del Monte, M.C.Serrano (2015) "Sub-acute Tissue Response to 3D Graphene Oxide Scaffolds Implanted in the Injured Rat Spinal Cord" Adv. Healthc. Mater. 4: 1861-1868, Back Cover
  • M.C.Matesanz, J.Linares, M.Oñaderra, M.J.Feito, F.J.Martínez-Vázquez, D.Arcos, S.Sánchez-Salcedo, M.T.Portolés y M.Vallet-Regí (2015) “Response of osteoblasts and preosteoblast to calcium deficient and Si substituted hydroxyapatites treated at different temperatures” Colloids Surf., B 133: 304-313
  • J.Linares, M.C.Matesanz, M.Vila, M.J.Feito, G.Gonçalves, M.Vallet-Regí, P.A.A.P.Marques y M.T.Portolés (2014) “Endocytic mechanisms of graphene oxide nanosheets in osteoblasts, hepatocytes and macrophages” ACS Appl. Mater. Inter. 6:13697-13706
  • M.J.Feito, M.Vila, M.C.Matesanz, J.Linares, G.Gonçalves, P.A.Marques, M.Vallet-Regí, J.M.Rojo y M.T.Portolés (2014) “In vitro evaluation of graphene oxide nanosheets on immune function” (2014) J. Colloid Interf. Sci. 432: 221-228
  • M.Cicuéndez, P.Portolés, M.Montes-Casado, I.Izquierdo-Barba, M.Vallet-Regí y M.T.Portolés (2014) “Effects of 3D nanocomposite bioceramic scaffolds on the immune response” J. Mater. Chem. B 2: 3469-3479
  • M.C.Matesanz, J.Linares, l.Lilue, S.Sánchez-Salcedo, M.J Feito, D.Arcos M.Vallet-Regí y M.T.Portolés (2014) “Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity” J. Mater. Chem. B 2: 2910-2919
  • M.V.Cabañas, J.Peña, J.Román, C.Ramírez-Santillán, M.C.Matesanz, M.J.Feito, M.T.Portolés y M.Vallet-Regí (2014) “Un nuevo sustituto óseo para regenerar los huesos” Primer premio en la modalidad de noticias científicas del V Concurso de Divulgación Científica de la UCM http://www.madrimasd.org/informacionidi/noticias/noticia.asp?id=61477&origen=notiweb&dia_suplemento=jueves
  • M.V.Cabañas, J.Peña, J.Román, C.Ramírez-Santillán, M.C.Matesanz, M.J.Feito, M.T.Portolés y M.Vallet-Regí (2014) “Design of tunable protein-releasing nanoapatite/hydrogel scaffolds for hard tissue engineering” Mater. Chem. Phys. 144: 409-417
  • M.Vila, M.C.Matesanz, G.Gonçalves, M.J.Feito, J.Linares, P.A.Marques, M.T.Portolés, M.Vallet-Regí (2014) “Triggering cell death by nanographene oxide mediated hyperthermia” Global Medical Discovery, Key Nanotechnology Articles, June 27, 2014 https://globalmedicaldiscovery.com/category/key-nanotechnology-articles/page/5/
  • M.Vila, M.C.Matesanz, G.Gonçalves, M.J.Feito, J.Linares, P.A.Marques, M.T.Portolés, M.Vallet-Regí (2014) “Triggering cell death by nanographene oxide mediated hyperthermia” Nanotechnol. 25: 035101 (7pp)
  • M.Cicuéndez, M.Malmsten, J.C.Doadrio, M.T.Portolés, I.Izquierdo-Barba y M.Vallet-Regí (2014) “Tailoring hierarchical meso-macroporous 3D scaffolds: From nano to macro” J. Mater. Chem. B 2: 49–58, Front Cover
  • M.C.Matesanz, M.J.Feito, M. Oñaderra, C.Ramírez-Santillán, C.daCasa, D.Arcos, M.Vallet-Regí, J.M.Rojo y M.T.Portolés (2014) “Early in vitro response of macrophages and T lymphocytes to nanocrystalline hydroxyapaties” J. Colloid Interf. Sci. 416: 59–66